MRAS and PIK3CA

Number of citations of the paper that reports this interaction (PMID 10803462)
9

Data Source:
HPRD (in vitro)

		MRAS	PIK3CA
Gene Name		muscle RAS oncogene homolog	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Extracellular Vesicular Exosome	Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Lamellipodium
	Molecular Function	GTPase Activity GTP Binding GTP-dependent Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Protein Kinase Activator Activity Phosphatidylinositol 3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Insulin Receptor Substrate Binding Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity
	Biological Process	Ras Protein Signal Transduction Multicellular Organismal Development Muscle Organ Development Actin Cytoskeleton Organization	Angiogenesis Vasculature Development Glucose Metabolic Process Protein Phosphorylation Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Epidermal Growth Factor Receptor Signaling Pathway Blood Coagulation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Platelet Activation T Cell Costimulation Positive Regulation Of Peptidyl-serine Phosphorylation Phosphatidylinositol-3-phosphate Biosynthetic Process Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Multicellular Organism Growth Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Endothelial Cell Migration Hypomethylation Of CpG Island Small Molecule Metabolic Process Innate Immune Response Positive Regulation Of Protein Kinase Activity Phosphatidylinositol Phosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway Leukocyte Migration Cardiac Muscle Contraction Negative Regulation Of Fibroblast Apoptotic Process Regulation Of Genetic Imprinting Negative Regulation Of Anoikis
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by GPCR Metabolism of lipids and lipoproteins Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Interleukin receptor SHC signaling PI-3K cascade Gastrin-CREB signalling pathway via PKC and MAPK Signaling by FGFR1 mutants Role of phospholipids in phagocytosis Phospholipid metabolism Fcgamma receptor (FCGR) dependent phagocytosis PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome G-protein beta:gamma signalling CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling G alpha (q) signalling events Signaling by ERBB2 Signaling by EGFR GPCR downstream signaling TCR signaling Signaling by Interleukins Signaling by VEGF Downstream signal transduction Signaling by FGFR mutants Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Nephrin interactions Interleukin-2 signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System G alpha (q) signalling events Downstream TCR signaling Costimulation by the CD28 family IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade VEGFA-VEGFR2 Pathway Synthesis of PIPs at the plasma membrane IRS-related events triggered by IGF1R G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling Regulation of signaling by CBL Downstream signaling of activated FGFR G alpha (12/13) signalling events PI Metabolism Innate Immune System Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall Signaling by FGFR IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) GPVI-mediated activation cascade Interleukin receptor SHC signaling Signaling by FGFR1 fusion mutants Constitutive Signaling by EGFRvIII PI3K Cascade
Drugs
Diseases
GWAS		Coronary heart disease ( 19198612 21378990)
Protein-Protein Interactions		10 interactors: BRAF MLLT4 PIK3CA RAF1 RALGDS RAPGEF5 RAPGEF6 RASIP1 RASSF5 TCEB1	43 interactors: ADAP1 AMBP APLP2 APPL1 ATPIF1 ATR DDX5 DNAJB6 FASLG FTL GABRB1 GNAQ GRIN2B HRAS IL3 IRS2 IRS4 ITIH1 KRAS LCK MRAS NEDD9 NRAS PDE4D PDGFRB PIK3R1 PIK3R3 PRKCD RASD2 RASGRP3 RPS20 RPS6KB1 SGK1 SH3KBP1 SLC9A3R1 SLC9A3R2 SMAD2 SMAD3 SQSTM1 STAT1 TICAM1 UFD1L VARS2
Entrez ID		22808	5290
HPRD ID		06662	01382
Ensembl ID		ENSG00000158186
Uniprot IDs		O14807 Q6FGP0 Q8WVM9	P42336
PDB IDs			2ENQ 2RD0 3HHM 3HIZ 3ZIM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Rap GTPase Activity Regulation Of Rap GTPase Activity Regulation Of Rap Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Regulation Of Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Cellular Response To Stimulus Regulation Of Ras Protein Signal Transduction Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of GTPase Activity Regulation Of Peptidyl-serine Phosphorylation Signal Transduction Regulation Of Metabolic Process Signaling Cell Communication Response To Stimulus Regulation Of Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Ras GTPase Activity Regulation Of Signaling Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cellular Response To Growth Factor Stimulus Response To Growth Factor Ras Protein Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of GTPase Activity Activation Of MAPKK Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Somatic Stem Cell Maintenance Death-inducing Signaling Complex Assembly Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Hydrolase Activity Positive Regulation Of Ras GTPase Activity Response To Peptide Hormone Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Hypomethylation Of CpG Island Response To Peptide Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Regulation Of Cellular Process	Regulation Of Signal Transduction Regulation Of Signaling Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Signaling Regulation Of Intracellular Signal Transduction Cell Communication Cellular Response To Organonitrogen Compound Positive Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Cellular Response To Stimulus Cellular Response To Insulin Stimulus Cellular Response To Peptide Hormone Stimulus Insulin Receptor Signaling Pathway Cellular Response To Peptide Regulation Of Catalytic Activity Cellular Response To Organic Substance Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Response To Growth Factor Regulation Of Phosphorylation Response To Organic Substance Regulation Of Cell Death Apoptotic Process Response To Insulin Intracellular Signal Transduction Programmed Cell Death Neurotrophin TRK Receptor Signaling Pathway Cell Death Death Neurotrophin Signaling Pathway Regulation Of Cell Proliferation Cellular Response To Growth Factor Stimulus Response To Peptide Hormone Fibroblast Growth Factor Receptor Signaling Pathway Response To Peptide Regulation Of Metabolic Process Response To Organonitrogen Compound Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Cellular Process Response To Fibroblast Growth Factor Regulation Of Immune Response Response To Stimulus Cellular Response To Hormone Stimulus Immune Response-regulating Signaling Pathway
Tagcloud ?		acetylcholine anion antihypertensive assume bioavailability cuff cyclooxygenase deleterious deoxycorticosterone doca gavage hypertension hypertensive mesenteric myograph nad nak nakatpase ouabain reasonable relaxation rosta rostafuroxin salt sbp uninephrectomized wire wistar	amplified biomarker e542k e545d e545k embedded fixed formalin h1047l h1047r homolog metastatic namely next oncogenic paraffin phospho phosphoinositol pi3k pras40thr246 proline pten reflect refractory respond retrospectively tensin trastuzumab unlikely
Tagcloud (Difference) ?		acetylcholine anion antihypertensive assume bioavailability cuff cyclooxygenase deleterious deoxycorticosterone doca gavage hypertension hypertensive mesenteric myograph nad nak nakatpase ouabain reasonable relaxation rosta rostafuroxin salt sbp uninephrectomized wire wistar	amplified biomarker e542k e545d e545k embedded fixed formalin h1047l h1047r homolog metastatic namely next oncogenic paraffin phospho phosphoinositol pi3k pras40thr246 proline pten reflect refractory respond retrospectively tensin trastuzumab unlikely
Tagcloud (Intersection) ?