MRAS and RAPGEF5

Number of citations of the paper that reports this interaction (PubMedID 10934204)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		MRAS	RAPGEF5
Description		muscle RAS oncogene homolog	Rap guanine nucleotide exchange factor 5
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GO Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Plasma Membrane Membrane	Nucleus Nucleoplasm Plasma Membrane Nuclear Body
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding GTP-dependent Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP-dependent Protein Binding
	Biological Process	Signal Transduction Ras Protein Signal Transduction Actin Cytoskeleton Organization Cellular Response To Leukemia Inhibitory Factor	Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Nervous System Development
Pathways		RAF activation SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling
Drugs
Diseases
GWAS		A body shape index ( 34021172) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blond vs. brown/black hair color ( 30531825) Body mass index ( 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Chronotype ( 30696823) Coronary artery disease ( 24262325 33020668 32469254 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990 19198612) Daytime nap ( 33568662) Diastolic blood pressure ( 27841878) Essential hypertension (time to event) ( 32589924) Myocardial infarction ( 33532862) Systolic blood pressure ( 27841878) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Asthma ( 34103634) Cutaneous malignant melanoma ( 32341527) Depression in smokers ( 30219690) Dialysis-related mortality ( 21546767) Diastolic blood pressure ( 30224653) Gamma glutamyl transferase levels ( 33339817) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Night sleep phenotypes ( 27126917) Spatial processing ( 31596458) Squamous cell lung carcinoma ( 28604730) Thyroid stimulating hormone levels ( 17903292) Urinary albumin excretion ( 32277301)
Interacting Genes		11 interacting genes: AFDN BRAF ELOC PIK3CA RAF1 RALGDS RAPGEF5 RAPGEF6 RASIP1 RASSF5 RHOU	7 interacting genes: MRAS PLAC9 RAP1A RAP2A RAP2B TMEM253 VANGL1
Entrez ID		22808	9771
HPRD ID		06662	15208
Ensembl ID		ENSG00000158186	ENSG00000136237
Uniprot IDs		O14807 Q6FGP0 Q8WVM9	A0A0S2Z561 A8MQ07 Q92565
PDB IDs		7SD0 7TVF 7TXH 7UPI 9B4R 9B4T 9C1A 9C1B	1WGY
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Signal Transduction Guanyl-nucleotide Exchange Factor Activity ERBB Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Small GTPase Binding Intracellular Signal Transduction Establishment Of Endothelial Intestinal Barrier Face Development Positive Regulation Of Peptidyl-serine Phosphorylation GTP-dependent Protein Binding MAP Kinase Kinase Kinase Activity Response To Muscle Stretch Regulation Of Peptidyl-serine Phosphorylation Thyroid Gland Development Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Establishment Of Endothelial Barrier Endothelial Cell Development Positive Regulation Of Cellular Component Organization Thymus Development Regulation Of Protein Modification Process Gland Development Negative Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Regulation Of Small GTPase Mediated Signal Transduction Protein Serine Kinase Activity Positive Regulation Of Cell Projection Organization Actin Cytoskeleton Organization Insulin Receptor Signaling Pathway Death-inducing Signaling Complex Assembly Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity Intracellular Glucose Homeostasis Regulation Of Rho Protein Signal Transduction Positive Regulation Of Protein Modification Process Regulation Of Cellular Component Organization Apoptotic Process Plasma Membrane Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Programmed Cell Death Actin Filament-based Process T Cell Receptor Signaling Pathway Cell Death Hematopoietic Or Lymphoid Organ Development Protein Serine/threonine Kinase Activity Regulation Of Protein Localization Negative Regulation Of Autophagy	Rap Protein Signal Transduction GDP Binding G Protein Activity Small GTPase-mediated Signal Transduction GTPase Activity GTP Binding Bounding Membrane Of Organelle Establishment Of Endothelial Barrier Endothelial Cell Development Intracellular Signaling Cassette Specific Granule Membrane Integrin Alphav-beta8 Complex Response To Antineoplastic Agent Recycling Endosome Membrane Epithelial Cell Development Langerhans Cell Differentiation Recycling Endosome Extracellular Matrix Protein Binding Positive Regulation Of Microvillus Assembly Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Synaptic Vesicle Exocytosis Cytoplasmic Vesicle Membrane
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