MBD2 and GATAD2B

Number of citations of the paper that reports this interaction (PMID 11756549)
21

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		MBD2	GATAD2B
Gene Name		methyl-CpG binding domain protein 2	GATA zinc finger domain containing 2B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm Cytoplasm Protein Complex	Nuclear Chromatin Nucleoplasm Nuclear Speck Protein Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Satellite DNA Binding MRNA Binding Protein Binding Methyl-CpG Binding Protein Domain Specific Binding Nucleosomal DNA Binding SiRNA Binding C2H2 Zinc Finger Domain Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Zinc Ion Binding Nucleosomal DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Gene Expression Positive Regulation Of Wnt Signaling Pathway Regulation Of Gene Expression, Epigenetic Regulation Of Cell Proliferation Maternal Behavior ATP-dependent Chromatin Remodeling Cellular Protein Complex Assembly Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated	Transcription, DNA-templated Regulation Of Transcription, DNA-templated ATP-dependent Chromatin Remodeling
Pathways		NoRC negatively regulates rRNA expression RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Promoter Clearance Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression RNA Polymerase I Promoter Opening	Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance
Drugs
Diseases
GWAS			Lentiform nucleus volume ( 22903471)
Protein-Protein Interactions		14 interactors: CREBBP DHX9 GATAD2A GATAD2B GPN1 HDAC1 HDAC2 HINFP LAMTOR3 MBD3 MBD3L1 MBD3L2 RBBP4 SIN3A	20 interactors: CALCOCO2 CEP70 GOLGA2 HDAC1 HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE KAT2B MBD2 MBD3 PRKAB2 RBBP4 RBBP7 RPGRIP1 SMAD2 TEX11 TRAF1 TRIM27 USHBP1
Entrez ID		8932	57459
HPRD ID		04647	15094
Ensembl ID		ENSG00000134046	ENSG00000143614
Uniprot IDs		Q9UBB5	Q8WXI9
PDB IDs		2L2L
Enriched GO Terms of Interacting Partners?		ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Chromatin Modification Chromosome Organization Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Chromatin Organization Chromatin Remodeling Gene Expression Negative Regulation Of Gene Expression Rhythmic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryo Development Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone Modification Macromolecule Biosynthetic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Histone Deacetylation Cellular Response To Heat Protein Deacetylation Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Embryonic Digit Morphogenesis Fungiform Papilla Formation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Fungiform Papilla Morphogenesis Positive Regulation Of Receptor Biosynthetic Process Fungiform Papilla Development Eyelid Development In Camera-type Eye Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Hair Follicle Placode Formation Response To Heat Tongue Morphogenesis Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Receptor Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Histone H4 Deacetylation	Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic ATP-dependent Chromatin Remodeling Chromatin Remodeling Chromosome Organization Chromatin Organization Protein Complex Assembly Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly Organelle Organization Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Chromatin Modification Negative Regulation Of Gene Expression DNA Packaging Cellular Macromolecular Complex Assembly Cellular Component Assembly Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process CENP-A Containing Nucleosome Assembly Gene Silencing DNA Conformation Change Chromatin Silencing Histone Exchange DNA Replication-independent Nucleosome Assembly Negative Regulation Of Biosynthetic Process Cell Cycle Centromere Complex Assembly Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation On Cytosine Chromatin Silencing At RDNA Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Viral Transcription Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated Histone Modification Mitotic Cell Cycle RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?		additionally adipose closely cpg deacetylases detailed dio dnmts epigenetic fatty feedback h3k4 h4 hdacs histones hypoacetylated hypomethylated island leptin maintain methyltransferases modification modifications obese obesity pol polyunsaturated pufas serve	520d 5p biomaterial cd105 combinatorial convert converted dedifferentiation demethylation elavl2 fibroblasts hsa ipscs lost microrna mir mscs never pluripotent safely stemness survived tead1 transfectants transfection transfections tumorigenicity turned usefulness
Tagcloud (Difference) ?		additionally adipose closely cpg deacetylases detailed dio dnmts epigenetic fatty feedback h3k4 h4 hdacs histones hypoacetylated hypomethylated island leptin maintain methyltransferases modification modifications obese obesity pol polyunsaturated pufas serve	520d 5p biomaterial cd105 combinatorial convert converted dedifferentiation demethylation elavl2 fibroblasts hsa ipscs lost microrna mir mscs never pluripotent safely stemness survived tead1 transfectants transfection transfections tumorigenicity turned usefulness
Tagcloud (Intersection) ?