MBD2 and CREBBP

Number of citations of the paper that reports this interaction (PMID 12665568)
10

Data Source:
HPRD (in vivo)

		MBD2	CREBBP
Gene Name		methyl-CpG binding domain protein 2	CREB binding protein
Image
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm Cytoplasm Protein Complex	Histone Acetyltransferase Complex Nuclear Chromatin Condensed Chromosome Outer Kinetochore Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Nuclear Body
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Satellite DNA Binding MRNA Binding Protein Binding Methyl-CpG Binding Protein Domain Specific Binding Nucleosomal DNA Binding SiRNA Binding C2H2 Zinc Finger Domain Binding	Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Factor Binding RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription P53 Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Histone Acetyltransferase Activity Signal Transducer Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Acetyltransferase Activity MRF Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Gene Expression Positive Regulation Of Wnt Signaling Pathway Regulation Of Gene Expression, Epigenetic Regulation Of Cell Proliferation Maternal Behavior ATP-dependent Chromatin Remodeling Cellular Protein Complex Assembly Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Hypoxia Chromatin Organization Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Protein Complex Assembly Signal Transduction Notch Signaling Pathway Regulation Of Smoothened Signaling Pathway Gene Expression Viral Process Histone Acetylation N-terminal Peptidyl-lysine Acetylation Germ-line Stem Cell Maintenance Positive Regulation Of Type I Interferon Production Cellular Response To Heat Homeostatic Process Embryonic Digit Morphogenesis Cellular Lipid Metabolic Process Small Molecule Metabolic Process Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Regulation Of Cellular Response To Heat
Pathways		NoRC negatively regulates rRNA expression RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Promoter Clearance Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression RNA Polymerase I Promoter Opening	Signaling by NOTCH1 HD Domain Mutants in Cancer Metabolism of lipids and lipoproteins Signaling by Wnt Regulation of gene expression by Hypoxia-inducible Factor Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Pre-NOTCH Transcription and Translation RNF mutants show enhanced WNT signaling and proliferation Signaling by NOTCH1 in Cancer Orphan transporters Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by NOTCH formation of the beta-catenin:TCF transactivating complex Factors involved in megakaryocyte development and platelet production Chromatin modifying enzymes LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Signaling by NOTCH1 PEST Domain Mutants in Cancer Activation of gene expression by SREBF (SREBP) Transcriptional activation of mitochondrial biogenesis Constitutive Signaling by NOTCH1 PEST Domain Mutants PPARA activates gene expression Cellular response to hypoxia Organelle biogenesis and maintenance Regulation of Hypoxia-inducible Factor (HIF) by oxygen Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Attenuation phase HATs acetylate histones RORA activates circadian gene expression Regulation of cholesterol biosynthesis by SREBP (SREBF) HSF1-dependent transactivation TRAF3-dependent IRF activation pathway Signaling by NOTCH1 Transcriptional regulation of white adipocyte differentiation XAV939 inhibits tankyrase, stabilizing AXIN Pre-NOTCH Expression and Processing Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Innate Immune System FBXW7 Mutants and NOTCH1 in Cancer Fatty acid, triacylglycerol, and ketone body metabolism Cytosolic sensors of pathogen-associated DNA Cellular response to heat stress REV-ERBA represses gene expression Mitochondrial biogenesis Notch-HLH transcription pathway RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways NOTCH1 Intracellular Domain Regulates Transcription TCF dependent signaling in response to WNT TRAF6 mediated IRF7 activation YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Signaling by WNT in cancer BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS			Metabolite levels (HVA/5-HIAA ratio) ( 23319000) Obesity-related traits ( 23251661) QT interval (interaction) ( 23459443)
Protein-Protein Interactions		14 interactors: CREBBP DHX9 GATAD2A GATAD2B GPN1 HDAC1 HDAC2 HINFP LAMTOR3 MBD3 MBD3L1 MBD3L2 RBBP4 SIN3A	253 interactors: ACTA2 ACVR1 AIRE AKT1 ALX1 ANAPC5 ANAPC7 AP1B1 APC AR ATF1 ATF3 BCL3 BCL6 BRCA1 CALCOCO1 CAMK4 CARM1 CDC25B CDH2 CDK5RAP3 CDX2 CEBPA CEBPB CEBPD CENPJ CHUK CITED1 CITED2 CNOT3 CNTN2 CREB1 CREM CRX CSK CSNK2A1 CSNK2A2 CTBP1 CTNNB1 CUX1 DACH1 DAXX DDX17 DDX5 DEK E2F1 E2F3 E2F5 EBF1 EGR1 EID1 EID3 EIF2B1 ELF3 ELK1 EP300 ESR1 ETS1 ETS2 EWSR1 FGFR1 FHL2 FOS FOXM1 FOXO1 FOXO4 GABPA GAK GATA1 GCM1 GLI3 GMEB1 GMEB2 GTF2B H3F3A HBP1 HCK HDAC1 HDAC3 HIF1A HIPK2 HIST1H2BB HIST1H3A HIST1H4A HIST2H2BE HIST3H3 HIST4H4 HLF HMGA1 HMGB1 HMGB2 HNF1A HNF1B HNF4A HOXA10 HOXA11 HOXA9 HOXB1 HOXB2 HOXB3 HOXB4 HOXB6 HOXB7 HOXB9 HOXD10 HOXD12 HOXD13 HOXD4 HSF1 HTT IKBKG IRF1 IRF3 IRF5 IRF7 JDP2 JUN KAT2A KAT2B KAT5 KAT6A KDM3B KHDRBS1 KLF1 KLF13 KLF4 KLF5 KMT2A KPNA2 KPNA6 LDLR LIG4 LYN MAF MAFG MAML1 MAML2 MAP3K5 MAPK1 MAPK10 MAPK3 MBD2 MDC1 MDM2 MECOM MED25 MGMT MIER1 MKNK1 MSH2 MSH6 MSX1 MYB MYBL1 MYBL2 MYC MYOD1 N4BP2 NAP1L1 NCOA1 NCOA2 NCOA3 NCOA6 NEUROG1 NFATC2 NFATC4 NFE2 NFE2L2 NFIA NFIC NKX2-1 NLK NPAS2 NPAT NR3C1 NR5A1 NUP98 ONECUT1 PARP1 PAX5 PBX1 PCMT1 PELP1 PHOX2A PIAS1 PLAGL1 PML POLR2A POU1F1 POU2F3 PPARG PPARGC1A PRKCD PRLR PROX1 PSME3 PTMA RAD23A RBBP4 RBBP7 RBCK1 RELA RPS6KA1 RPS6KA3 RPS6KA5 RXRG SERTAD1 SERTAD2 SERTAD3 SH3GL1 SMAD2 SMAD3 SMAD4 SND1 SNIP1 SOX9 SPI1 SPIB SRCAP SREBF1 SREBF2 SRF SS18L1 STAT1 STAT2 STAT3 STAT4 STAT6 SUV39H1 TACC2 TAF6L TCF12 TCF3 TDG TFDP1 TGS1 THRA TP53 TP73 TRERF1 TRIP10 TRIP4 UBE2D1 UBE2I UBTF VDR WT1 XAF1 XRCC6 YWHAH ZBTB17 ZBTB2 ZNF639
Entrez ID		8932	1387
HPRD ID		04647	02534
Ensembl ID		ENSG00000134046	ENSG00000005339
Uniprot IDs		Q9UBB5	Q92793
PDB IDs		2L2L	1JSP 1LIQ 1RDT 1WO3 1WO4 1WO5 1WO6 1WO7 1ZOQ 2D82 2KJE 2KWF 2L84 2L85 2LXS 2LXT 2RNY 3DWY 3P1C 3P1D 3P1E 3P1F 3SVH 4A9K
Enriched GO Terms of Interacting Partners?		ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Chromatin Modification Chromosome Organization Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Chromatin Organization Chromatin Remodeling Gene Expression Negative Regulation Of Gene Expression Rhythmic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryo Development Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone Modification Macromolecule Biosynthetic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Histone Deacetylation Cellular Response To Heat Protein Deacetylation Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Embryonic Digit Morphogenesis Fungiform Papilla Formation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Fungiform Papilla Morphogenesis Positive Regulation Of Receptor Biosynthetic Process Fungiform Papilla Development Eyelid Development In Camera-type Eye Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Hair Follicle Placode Formation Response To Heat Tongue Morphogenesis Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Receptor Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Histone H4 Deacetylation	Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Biosynthetic Process Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Biosynthetic Process Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Developmental Process Organ Development Multicellular Organismal Development System Development Anatomical Structure Development Response To Organic Substance Metabolic Process Cell Differentiation Cellular Response To Organic Substance Regulation Of Cell Differentiation Regulation Of Cell Proliferation Tissue Development Cellular Response To Stress
Tagcloud ?		additionally adipose closely cpg deacetylases detailed dio dnmts epigenetic fatty feedback h3k4 h4 hdacs histones hypoacetylated hypomethylated island leptin maintain methyltransferases modification modifications obese obesity pol polyunsaturated pufas serve	adulthood amp backgroundrubinstein big births broad consuming cooperation costly disabilities discussionrsts dysmorphic ep300 establishing extremely facial highlighted intellectual microcephaly multicenter retardation rsts summarized summarythe survive taybi thumbs toe toes
Tagcloud (Difference) ?		additionally adipose closely cpg deacetylases detailed dio dnmts epigenetic fatty feedback h3k4 h4 hdacs histones hypoacetylated hypomethylated island leptin maintain methyltransferases modification modifications obese obesity pol polyunsaturated pufas serve	adulthood amp backgroundrubinstein big births broad consuming cooperation costly disabilities discussionrsts dysmorphic ep300 establishing extremely facial highlighted intellectual microcephaly multicenter retardation rsts summarized summarythe survive taybi thumbs toe toes
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