MBD2 and DHX9

Number of citations of the paper that reports this interaction (PubMedID 12665568)
62

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		MBD2	DHX9
Description		methyl-CpG binding domain protein 2	DExH-box helicase 9
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GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Heterochromatin Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol NuRD Complex Protein-containing Complex	Nucleus Nucleoplasm Perichromatin Fibrils Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Actin Cytoskeleton Membrane RISC Complex Nuclear Body Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule RISC-loading Complex CRD-mediated MRNA Stability Complex Nuclear Stress Granule Ribonucleoprotein Complex
	Molecular Function	DNA Binding Chromatin Binding Satellite DNA Binding MRNA Binding Protein Binding Methyl-CpG Binding Protein Domain Specific Binding Nucleosomal DNA Binding SiRNA Binding Identical Protein Binding Molecular Adaptor Activity C2H2 Zinc Finger Domain Binding	Nucleotide Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding Regulatory Region RNA Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity DNA Replication Origin Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding MRNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Ribonucleoside Triphosphate Phosphatase Activity Chromatin DNA Binding 3'-5' DNA/RNA Helicase Activity 3'-5' RNA Helicase Activity SiRNA Binding RNA Stem-loop Binding Ribosome Binding 3'-5' DNA Helicase Activity Triplex DNA Binding Metal Ion Binding Nucleoside Triphosphate Diphosphatase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Importin-alpha Family Protein Binding RNA Polymerase Binding Catalytic Activity, Acting On A Nucleic Acid RISC Complex Binding Single-stranded 3'-5' DNA Helicase Activity Sequence-specific MRNA Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ventricular Cardiac Muscle Tissue Development Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of Transcription By RNA Polymerase II Response To Mechanical Stimulus Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Response To Nutrient Levels Response To Estradiol Epigenetic Regulation Of Gene Expression Regulation Of Cell Population Proliferation Maternal Behavior Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Embryonic Organ Development Protein-containing Complex Assembly Response To Bisphenol A Cellular Response To Serotonin	Alternative MRNA Splicing, Via Spliceosome Osteoblast Differentiation Immune System Process DNA Replication Chromatin Organization DNA-templated Transcription Termination Regulation Of Transcription By RNA Polymerase II MRNA Processing Regulation Of Translation Inflammatory Response RNA Splicing Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production MiRNA-mediated Post-transcriptional Gene Silencing DNA-templated Viral Transcription Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of DNA Repair Positive Regulation Of DNA Replication Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Export From Nucleus Positive Regulation Of Fibroblast Proliferation Rhythmic Process Positive Regulation Of Viral Transcription Regulation Of MRNA Processing Regulation Of Defense Response To Virus By Host Positive Regulation Of Inflammatory Response MRNA Transport Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Response To Cytokine Stimulus Protein-containing Complex Assembly Pyroptotic Inflammatory Response RISC Complex Assembly CRD-mediated MRNA Stabilization Cellular Response To Exogenous DsRNA Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Protein Localization To Cytoplasmic Stress Granule Regulation Of Cytoplasmic Translation Positive Regulation Of Cytoplasmic Translation
Pathways		NoRC negatively regulates rRNA expression RNA Polymerase I Promoter Opening	RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production mRNA Splicing - Major Pathway PKR-mediated signaling
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Body size at age 10 ( 32376654) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Nickel levels ( 26025379) Periodontitis (Mean PAL) ( 24024966) Prostate cancer ( 29892016) Psoriasis ( 23143594)
Interacting Genes		21 interacting genes: BEND7 C1QBP CREBBP DHX9 GATAD2A GATAD2B GPN1 HDAC1 HDAC2 HINFP LAMTOR3 MBD3 MBD3L1 MBD3L2 PRMT1 PURB RALYL RBBP4 SIN3A SMN2 TBP	44 interacting genes: ACTA1 AKAP8L APBB1 BRCA1 DDX20 DUX4 GEMIN2 GEMIN4 GTF2B HDLBP HNRNPC HNRNPK IL7R ILF3 JUN KHDRBS1 LINC01016 LINC01554 MBD2 NXF1 OGA OGT PCNA POLR2A PRMT1 PRPF40A PRPF8 PTEN RBM4 RELA RNF10 RNF168 SMN1 SMN2 SNRPB SNRPB2 SRPK1 SSRP1 STAU1 TBP TOP2A UBE2I USP7 YWHAQ
Entrez ID		8932	1660
HPRD ID		04647	04386
Ensembl ID		ENSG00000134046	ENSG00000135829
Uniprot IDs		Q9UBB5	B3KU66 Q08211
PDB IDs		2L2L 6C1A 6C1T 6C1U 6C1V 6C2F 6CNP 6CNQ 7AO8 7AO9 7AOA 7MWK 7MWM 7RAY	3LLM 3VYX 3VYY 8SZP
Enriched GO Terms of Interacting Partners?		NuRD Complex Regulation Of Cell Fate Specification Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Fate Commitment Chromatin Organization Negative Regulation Of RNA Metabolic Process Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Stem Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Nucleosomal DNA Binding Negative Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sin3-type Complex Heterochromatin Formation Negative Regulation Of Gene Expression Negative Regulation Of Stem Cell Population Maintenance Negative Regulation Of Metabolic Process Methyl-CpG Binding Negative Regulation Of Gene Expression, Epigenetic Regulation Of RNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Complex Positive Regulation Of Stem Cell Population Maintenance Nucleoplasm Nucleus Constitutive Heterochromatin Formation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Epigenetic Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Biosynthetic Process Protein-containing Complex Regulation Of Stem Cell Population Maintenance DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Protein Lysine Delactylase Activity Fungiform Papilla Formation	RNA Splicing Nucleoplasm MRNA Metabolic Process MRNA Processing Nucleic Acid Metabolic Process Nucleus RNA Binding SMN-Sm Protein Complex Nucleobase-containing Compound Metabolic Process Spliceosomal SnRNP Assembly Macromolecule Metabolic Process RNA Processing SMN Complex Gemini Of Cajal Bodies RNA Metabolic Process RNA Splicing, Via Transesterification Reactions Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Protein-RNA Complex Assembly Spliceosomal Complex Assembly Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Nuclear Body Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Protein-containing Complex Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process MRNA Binding Protein-containing Complex Assembly Ribonucleoprotein Complex Regulation Of Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Protein-containing Complex Organization Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Catalytic Step 2 Spliceosome Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cytoplasm Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process
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