TAB2 and TRIM45

Number of citations of the paper that reports this interaction (PubMedID 36681779)
44

Data Source:
BioGRID (enzymatic study)

		TAB2	TRIM45
Description		TGF-beta activated kinase 1 (MAP3K7) binding protein 2	tripartite motif containing 45
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Endosome Cytosol Plasma Membrane Endosome Membrane Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Intercellular Bridge
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Binding Metal Ion Binding Molecular Adaptor Activity K63-linked Polyubiquitin Modification-dependent Protein Binding	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Inflammatory Response Canonical NF-kappaB Signal Transduction Heart Development Response To Bacterium Negative Regulation Of Autophagy Response To Lipopolysaccharide Non-canonical NF-kappaB Signal Transduction P38MAPK Cascade Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Kinase Activity Protein K63-linked Ubiquitination	Inflammatory Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Inflammatory Response Bone Development Protein K48-linked Ubiquitination
Pathways		Nuclear signaling by ERBB4 Nuclear signaling by ERBB4 NOD1/2 Signaling Pathway Downstream TCR signaling FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NF-kappa-B signaling pathway CLEC7A (Dectin-1) signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway SARS-CoV-2 activates/modulates innate and adaptive immune responses IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	Interferon gamma signaling
Drugs
Diseases
GWAS		Breast cancer ( 22383897 29059683) Coronary artery disease ( 33020668) Diverticulitis ( 28585551) Dupuytren's disease ( 21732829 28886342) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172)
Interacting Genes		44 interacting genes: APP CAMK2A CST9L EIF2AK2 EMILIN1 ERBB4 FN1 FOSL1 GTF2I HDAC1 HDAC3 HDAC5 HSF2BP IKBKB IKBKG IRAK1 KRT85 MAP3K7 NCOR1 NFKB1 NR2C2 NUMBL PPIL3 PPP2CB SLC19A3 TAB1 TBL1X TGM2 TNFRSF11A TPM3 TRAF2 TRAF3IP1 TRAF6 TRIM45 TTN UBC UBE2I VIM VPS52 XIAP YWHAZ ZBTB16 ZFP64 ZNF143	18 interacting genes: CDC42 GABARAPL2 MED10 MEOX2 PTGES3L-AARSD1 TAB2 TAX1BP1 TEPSIN TFIP11 UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 ZMYND19
Entrez ID		23118	80263
HPRD ID		05483	15562
Ensembl ID		ENSG00000055208	ENSG00000134253
Uniprot IDs		B4DIR9 Q9NYJ8	Q9H8W5
PDB IDs		2DAE 2WWZ 2WX0 2WX1 9AVT 9AVW	2DS4
Enriched GO Terms of Interacting Partners?		Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Gene Expression Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of JNK Cascade Response To External Biotic Stimulus Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Defense Response Positive Regulation Of Metabolic Process Defense Response Regulation Of Signaling Positive Regulation Of Defense Response Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Communication Identical Protein Binding Regulation Of Macromolecule Metabolic Process Protein Modification Process Positive Regulation Of Multicellular Organismal Process MyD88-dependent Toll-like Receptor Signaling Pathway Histone Deacetylase Complex Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Negative Regulation Of Macromolecule Biosynthetic Process Cytosol Toll-like Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Negative Regulation Of Biosynthetic Process Pattern Recognition Receptor Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Immune Response-activating Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of DNA-templated Transcription Innate Immune Response-activating Signaling Pathway Response To Other Organism	Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein K11-linked Ubiquitination Protein K63-linked Ubiquitination Protein Modification Process Protein Monoubiquitination ISG15 Transferase Activity Ubiquitin-dependent Protein Catabolic Process ISG15-protein Conjugation Modification-dependent Protein Catabolic Process Nucleotide Binding Ubiquitin Protein Ligase Activity Protein Metabolic Process ATP Binding Proteolysis Involved In Protein Catabolic Process Protein Autoubiquitination Transferase Activity Protein K6-linked Ubiquitination Catabolic Process Macromolecule Catabolic Process Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Proteolysis Coated Vesicle Membrane GBD Domain Binding Storage Vacuole Positive Regulation Of Reciprocal Meiotic Recombination Protein Localization To Phagocytic Vesicle Spliceosomal Complex Disassembly Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Cell Cycle Process Negative Regulation Of Macromolecule Metabolic Process
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