DLX3 and TDP2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		DLX3	TDP2
Description		distal-less homeobox 3	tyrosyl-DNA phosphodiesterase 2
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GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm	Nucleus Nucleoplasm Nucleolus Cytoplasm Aggresome Nuclear Body PML Body
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Magnesium Ion Binding DNA Binding Single-stranded DNA Binding Transcription Corepressor Activity Catalytic Activity Nuclease Activity Protein Binding Hydrolase Activity Manganese Ion Binding Tyrosyl-RNA Phosphodiesterase Activity Metal Ion Binding Tyrosyl-DNA Phosphodiesterase Activity 5'-tyrosyl-DNA Phosphodiesterase Activity
	Biological Process	Blood Vessel Development Placenta Development Hair Follicle Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Gene Expression Wnt Signaling Pathway BMP Signaling Pathway Epithelial Cell Differentiation Hair Follicle Morphogenesis Hair Cell Differentiation Odontogenesis Of Dentin-containing Tooth Hair Cycle Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Development Hair Follicle Cell Proliferation Odontoblast Differentiation	DNA Repair Double-strand Break Repair DNA Damage Response Cell Surface Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Neuron Development
Pathways			Nonhomologous End-Joining (NHEJ)
Drugs
Diseases		Trichodentoosseous dysplasia Amelogenesis imperfecta hypoplastic-hypomaturation with taurodontism (AIHHT)
GWAS		Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701)	Colorectal or endometrial cancer ( 26621817)
Interacting Genes		5 interacting genes: BANP POU4F2 PRKCA TBL1X TDP2	36 interacting genes: AKAP19 AKAP9 ATP5MC2 ATXN1 BLK BTBD2 CD40 DLX3 DVL2 EPS8 ETS1 ETS2 FLI1 GOLGA2 JAM2 MAPK6 PSEN1 RAB11A SKIL SMAD3 SNX13 SRPK2 SUMO1 SUMO2 SUMO3 TAP1 TFIP11 TNFRSF1B TNFRSF8 TRAF2 TRAF3 TRAF5 TRAF6 UBE2I WBP2 ZBED1
Entrez ID		1747	51567
HPRD ID		02752	05771
Ensembl ID		ENSG00000064195	ENSG00000111802
Uniprot IDs		O60479	A0A384MDM5 O95551
PDB IDs		4XRS	5INO 5J3P 5J3S 6Q00 6Q01
Enriched GO Terms of Interacting Partners?		Response To Estradiol Nucleoplasm Regulation Of Myeloid Leukocyte Differentiation Negative Regulation Of Amacrine Cell Differentiation Axonogenesis Sensory Perception Of Mechanical Stimulus Positive Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Myeloid Cell Differentiation Sensory Perception Of Sound Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Angiotensin-activated Signaling Pathway Histone H3T6 Kinase Activity Alphav-beta3 Integrin-PKCalpha Complex 5'-tyrosyl-DNA Phosphodiesterase Activity Tyrosyl-RNA Phosphodiesterase Activity Tyrosyl-DNA Phosphodiesterase Activity Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Retinal Ganglion Cell Axon Guidance Positive Regulation Of Leukocyte Differentiation Negative Regulation Of Biosynthetic Process Nervous System Process Dorsal Root Ganglion Development Regulation Of Angiotensin-activated Signaling Pathway Protein Kinase C Signaling Transcription Corepressor Activity Regulation Of Myeloid Cell Differentiation Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Desmosome Assembly Positive Regulation Of Nervous System Development Negative Regulation Of Adipose Tissue Development Neuron Projection Morphogenesis Negative Regulation Of Macromolecule Metabolic Process Cell Projection Morphogenesis Negative Regulation Of Metabolic Process Positive Regulation Of Transcription Regulatory Region DNA Binding Response To Peptide Hormone Apoptotic Signaling Pathway Regulation Of Axon Guidance Mitotic Nuclear Membrane Disassembly Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Phorbol 13-acetate 12-myristate Negative Regulation Of Glial Cell Apoptotic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Bone Resorption Diacylglycerol Binding Ganglion Development Desmosome Organization Positive Regulation Of Macrophage Differentiation	CD40 Receptor Complex CD40 Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Protein Sumoylation Regulation Of Nucleobase-containing Compound Metabolic Process PML Body Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Ubiquitin Protein Ligase Binding Tumor Necrosis Factor Receptor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Thioesterase Binding Interleukin-17-mediated Signaling Pathway Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Protein Tag Activity Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Body Organization Negative Regulation Of DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression SUMO Transferase Activity Glutamatergic Synapse Ubiquitin-like Protein Ligase Binding Signaling Adaptor Activity Regulation Of Apoptotic Process Tumor Necrosis Factor Receptor Superfamily Complex Presynaptic Cytosol Positive Regulation Of Gene Expression Postsynaptic Cytosol Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Nucleoplasm Regulation Of DNA-binding Transcription Factor Activity Small Protein Activating Enzyme Binding Regulation Of Metabolic Process Intracellular Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Developmental Process Signal Transduction Involved In Regulation Of Gene Expression
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