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IKBKG and MERTK
Number of citations of the paper that reports this interaction (PubMedID
20098747
)
50
Data Source:
BioGRID
(pull down)
IKBKG
MERTK
Description
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
MER proto-oncogene, tyrosine kinase
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Spindle Pole
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
IkappaB Kinase Complex
Protein-containing Complex
Mitotic Spindle
Photoreceptor Outer Segment
Extracellular Space
Cytoplasm
Plasma Membrane
Membrane
Receptor Complex
Molecular Function
Protein Binding
Zinc Ion Binding
Protein Domain Specific Binding
Polyubiquitin Modification-dependent Protein Binding
Ubiquitin Protein Ligase Binding
Signaling Adaptor Activity
Identical Protein Binding
Protein Homodimerization Activity
Metal Ion Binding
Protein Heterodimerization Activity
K63-linked Polyubiquitin Modification-dependent Protein Binding
Linear Polyubiquitin Binding
Transferrin Receptor Binding
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Biological Process
B Cell Homeostasis
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Inflammatory Response
Immune Response
DNA Damage Response
Canonical NF-kappaB Signal Transduction
Response To Virus
Positive Regulation Of Gene Expression
Positive Regulation Of Macroautophagy
Defense Response To Bacterium
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Anoikis
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Establishment Of Vesicle Localization
Protein-containing Complex Assembly
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Natural Killer Cell Differentiation
Negative Regulation Of Cytokine Production
Protein Phosphorylation
Phagocytosis
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell-cell Signaling
Spermatogenesis
Nervous System Development
Cell Migration
Platelet Activation
Secretion By Cell
Substrate Adhesion-dependent Cell Spreading
Apoptotic Cell Clearance
Lymphocyte Activation
Positive Regulation Of Phagocytosis
Negative Regulation Of Lymphocyte Activation
Establishment Of Localization In Cell
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Retina Development In Camera-type Eye
Vagina Development
Neutrophil Clearance
Negative Regulation Of Leukocyte Apoptotic Process
Pathways
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
ER-Phagosome pathway
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
SUMOylation of immune response proteins
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
IKBKB deficiency causes SCID
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Ub-specific processing proteases
Ovarian tumor domain proteases
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
SARS-CoV-2 activates/modulates innate and adaptive immune responses
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Regulation of NF-kappa B signaling
PKR-mediated signaling
SLC15A4:TASL-dependent IRF5 activation
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Modulation of host responses by IFN-stimulated genes
Cell surface interactions at the vascular wall
Drugs
AGRO100
Tarenflurbil
2-({6-[(3-Chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)ethanol
Fostamatinib
Diseases
Incontinentia pigmenti
Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect
Osteoporosis, lymphedema, anhydrotic ectodermal dysplasia with immunodeficiency (OLEDAID); Ectodermal dysplasia, anhidrotic, with immunodeficiency, osteopetrosis, and lymphedema
Retinitis pigmentosa (RP)
GWAS
Hemoglobin levels (
26366553
)
Acute anterior uveitis in ankylosing spondylitis (
32492107
)
Alanine aminotransferase levels (
34315874
33547301
)
Appendicular lean mass (
33097823
)
Aspartate aminotransferase levels (
34315874
33547301
)
Cluster headache (
34184781
)
Coronary artery disease (
33020668
29212778
)
Haemorrhoidal disease (
33888516
)
Heel bone mineral density (
30598549
)
Hepatitis C induced liver fibrosis (
22841784
)
Multiple sclerosis (
21833088
31604244
)
Myocardial infarction (
33532862
)
Neutrophil percentage of white cells (
32888494
)
Systolic blood pressure (
30224653
)
Interacting Genes
241 interacting genes:
ABCA1
ACBD6
ADAP2
AIP
ALK
AMMECR1L
APRT
ARF4
ARF5
ARF6
ARGLU1
ARHGDIA
ARL6IP4
ARPP19
AVPI1
BCL10
BIRC2
BRME1
C19orf12
CALB1
CARD10
CARD11
CARD8
CASP6
CASP8
CCHCR1
CDC37
CDK2
CDKN1A
CETN3
CHUK
CLIC1
CNOT7
COPS3
CPNE2
CREBBP
CUEDC1
CWF19L2
CYLD
DAPK1
DDIT3
DDX19B
DNAJC8
DYNC1LI1
EEF1A1
EGFR
EGLN3
EIF1AX
ENKD1
EPHA4
FADD
FGR
FLT3
FLT4
FRMD8
GADD45G
GADD45GIP1
GCC1
GEMIN2
GFAP
GIT2
GLO1
GNGT1
GPKOW
GRK4
GSK3B
GTF2E1
GUCY1A1
GYG2
H1-0
HBZ
HCLS1
HDDC2
HIF1A
HLA-DQA1
HPCAL1
HPD
HSP90AA1
HSP90AB1
HSPA1A
HSPA4
ID1
ID3
IKBKB
INO80E
IRAK1
IRAK4
ITK
JAK2
JAK3
KANSL2
KIR3DX1
KRT18
KRT8
LCK
LENG8
LGALS2
LMCD1
LPXN
LUC7L2
LZIC
LZTR1
MACROD1
MAFIP
MAP3K14
MAP3K2
MAPRE1
MARCHF2
MCM10
MCM7
MED7
MERTK
MLLT6
MPRIP
MYD88
MYL5
MYO5C
MZT2A
NAP1L5
NCOA3
NECAB3
NFKB1
NFKB2
NFKBIA
NFKBIB
NHP2
NRARP
NRBF2
NTMT1
ODAM
OSBPL10
OSGIN1
PA2G4
PARP1
PCK1
PDCL
PFDN5
PHF7
PIM2
PLEKHJ1
PNMA8A
POLR2B
POLR2D
POLR2E
POLR3A
PPM1B
PRKCB
PRKCI
PRKCQ
PRKD3
PRKDC
PRKN
PRPF18
PSMA3
PSMB5
RAB11A
RAB11B
RAB8A
RALBP1
RBBP8
RBM34
RBM8A
RBP1
RET
RHOA
RIPK1
RIPK2
RNF11
RNF31
RNF34
RNF4
RNF7
ROR2
ROS1
RPL41
RPS12
RPS6KB2
SCLT1
SENP2
SEPTIN9
SGK1
SHTN1
SLU7
SNW1
SRC
SRPK1
SSX2IP
STK25
STX11
SUPT5H
SYT1
TAB1
TAB2
TAB3
TAF7
TANK
TARBP2
TAX1BP1
TBC1D7
TBK1
TCEANC
TCP10L
TCP11
TCP11L1
TEC
TEK
TMA16
TNF
TNFAIP3
TNFRSF1A
TNIP1
TNIP2
TPT1
TRAF3IP2
TRIM29
TRIM31
TRIM37
TRIM41
TRIOBP
TRPC4AP
TSLP
TTYH2
TUBG1
TXLNA
TYRO3
UBASH3A
UBB
UBC
UBE2D3
UBE2D4
UBE2I
USP2
VAMP3
WDR5
WWP1
ZBTB3
ZC3H12A
ZFAND5
ZNF587
ZNF835
ZZZ3
11 interacting genes:
BMPR2
DSCAM
ERBB2
GAS6
GRB2
IKBKG
LCOR
LMO4
NEDD4L
TNK2
VAV1
Entrez ID
8517
10461
HPRD ID
02217
05269
Ensembl ID
ENSG00000269335
ENSG00000153208
Uniprot IDs
A0A087X1B1
Q9Y6K9
Q12866
PDB IDs
2JVX
2JVY
3BRT
3BRV
3CL3
3FX0
4BWN
5AAY
5LDE
6MI3
6MI4
6XX0
6YEK
7T2U
7TV4
8U7C
9AZJ
2DBJ
2P0C
3BPR
3BRB
3TCP
4M3Q
4MH7
4MHA
5K0K
5K0X
5TC0
5TD2
5U6C
6MEP
7AAX
7AAY
7AAZ
7AB0
7AB1
7AB2
7AVX
7AVY
7AVZ
7AW0
7AW1
7AW2
7AW3
7AW4
7CQE
7DXL
7M5Z
7OAM
7OLS
7OLV
7OLX
7XHY
9BHI
9BHJ
9BHK
Enriched GO Terms of Interacting Partners
?
Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Cytoplasm
Protein Kinase Activity
Non-canonical NF-kappaB Signal Transduction
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Cytosol
Canonical NF-kappaB Signal Transduction
Kinase Activity
Regulation Of Immune Response
Regulation Of Innate Immune Response
Regulation Of Defense Response
Activation Of Innate Immune Response
Positive Regulation Of Defense Response
Positive Regulation Of Signal Transduction
Regulation Of Programmed Cell Death
Activation Of Immune Response
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Immune Response
Regulation Of Apoptotic Process
Positive Regulation Of Signaling
Intracellular Signal Transduction
Positive Regulation Of Innate Immune Response
Immune Response-activating Signaling Pathway
Protein Modification Process
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Immune Response-regulating Signaling Pathway
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Nucleotide Binding
Transferase Activity
Positive Regulation Of Cell Communication
Innate Immune Response-activating Signaling Pathway
Macromolecule Metabolic Process
Protein Tyrosine Kinase Activity
Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Regulation Of Cytokine-mediated Signaling Pathway
Intracellular Receptor Signaling Pathway
Regulation Of Immune System Process
Protein Phosphorylation
Protein Binding
Regulation Of Protein Modification Process
Protein Metabolic Process
ATP Binding
Negative Regulation Of Programmed Cell Death
Phosphorylation
Nucleus
Positive Regulation Of Phosphorylation
Grb2-EGFR Complex
Positive Regulation Of Phosphate Metabolic Process
Positive Regulation Of Cell Growth
Cell Surface Receptor Signaling Pathway
Regulation Of Phosphorylation
Endocytosis
Positive Regulation Of Axon Extension Involved In Axon Guidance
Positive Regulation Of Growth
Cell Differentiation
Regulation Of Phosphorus Metabolic Process
Regulation Of Cellular Component Organization
Positive Regulation Of Metabolic Process
Import Into Cell
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Cell Activation
Regulation Of Axon Extension Involved In Axon Guidance
Cellular Developmental Process
Schwann Cell Development
Regulation Of Cell Growth
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Kinase Activity
Positive Regulation Of Chemotaxis
Intracellular Signaling Cassette
Motor Neuron Axon Guidance
Positive Regulation Of Developmental Growth
Neuron Projection Development
Regulation Of Metabolic Process
Epidermal Growth Factor Receptor Binding
Regulation Of Lymphocyte Activation
Neuromuscular Junction Development
Positive Regulation Of Axon Extension
Regulation Of Chemotaxis
Natural Killer Cell Mediated Cytotoxicity
Protein Tyrosine Kinase Binding
Growth Factor Binding
Neuron Projection Guidance
Axon Guidance
Positive Regulation Of Protein Phosphorylation
Natural Killer Cell Mediated Immunity
T Cell Costimulation
Positive Regulation Of Cellular Component Organization
Regulation Of Growth
Phosphotyrosine Residue Binding
Positive Regulation Of Intracellular Signal Transduction
Immune Response-activating Cell Surface Receptor Signaling Pathway
Vesicle-mediated Transport
Synapse Organization
Regulation Of Kinase Activity
Regulation Of Natural Killer Cell Mediated Cytotoxicity
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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