IKBKG and CYLD

Number of citations of the paper that reports this interaction (PubMedID 31366726)
68

Data Source:
BioGRID (fluorescent resonance energy transfer, pull down)
HPRD (in vitro)

		IKBKG	CYLD
Description		inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	CYLD lysine 63 deubiquitinase
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Spindle Pole Nucleus Nucleoplasm Cytoplasm Cytosol IkappaB Kinase Complex Protein-containing Complex Mitotic Spindle	Nucleoplasm Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Microtubule Cytoplasmic Microtubule Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Midbody Centriolar Satellite Ciliary Basal Body Cell Projection Organelle Perinuclear Region Of Cytoplasm Ciliary Tip
	Molecular Function	Protein Binding Zinc Ion Binding Protein Domain Specific Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity K63-linked Polyubiquitin Modification-dependent Protein Binding Linear Polyubiquitin Binding Transferrin Receptor Binding	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Protein Kinase Binding Metal Ion Binding K63-linked Deubiquitinase Activity Met1-linked Polyubiquitin Deubiquitinase Activity Proline-rich Region Binding K48-linked Deubiquitinase Activity
	Biological Process	B Cell Homeostasis Regulation Of Transcription By RNA Polymerase II Apoptotic Process Inflammatory Response Immune Response DNA Damage Response Canonical NF-kappaB Signal Transduction Response To Virus Positive Regulation Of Gene Expression Positive Regulation Of Macroautophagy Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Anoikis Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Establishment Of Vesicle Localization Protein-containing Complex Assembly Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Immune System Process Proteolysis Canonical NF-kappaB Signal Transduction Regulation Of Mitotic Cell Cycle Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Deubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Innate Immune Response Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Negative Regulation Of JNK Cascade Homeostasis Of Number Of Cells Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Positive Regulation Of T Cell Receptor Signaling Pathway Regulation Of Necroptotic Process Necroptotic Process Regulation Of Microtubule Cytoskeleton Organization Protein K63-linked Deubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Ripoptosome Assembly Involved In Necroptotic Process Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Cilium Assembly Negative Regulation Of P38MAPK Cascade Positive Regulation Of Protein Localization Protein Linear Deubiquitination Negative Regulation Of Interleukin-18-mediated Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells ER-Phagosome pathway NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 Downstream TCR signaling FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 SUMOylation of immune response proteins Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway IKBKB deficiency causes SCID IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Ub-specific processing proteases Ovarian tumor domain proteases Interleukin-1 signaling TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 SARS-CoV-2 activates/modulates innate and adaptive immune responses IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Regulation of NF-kappa B signaling PKR-mediated signaling SLC15A4:TASL-dependent IRF5 activation Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Modulation of host responses by IFN-stimulated genes	NOD1/2 Signaling Pathway TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ub-specific processing proteases Negative regulators of DDX58/IFIH1 signaling
Drugs		AGRO100 Tarenflurbil
Diseases		Incontinentia pigmenti Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect Osteoporosis, lymphedema, anhydrotic ectodermal dysplasia with immunodeficiency (OLEDAID); Ectodermal dysplasia, anhidrotic, with immunodeficiency, osteopetrosis, and lymphedema	Brooke-Spiegler syndrome Multiple familial trichoepithelioma Familial cylindromatosis
GWAS		Hemoglobin levels ( 26366553)	Adventurousness ( 30643258) Asthma (childhood onset) ( 31036433) Asthma (time to onset) ( 27130862) Body mass index ( 28892062) Crohn's disease ( 22412388 28067908) Femoral neck bone mineral density ( 29499414) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 28067908) Leprosy ( 22019778 25642632) Lumbar spine bone mineral density ( 22504420 29499414) Serum metabolite levels ( 33031748)
Interacting Genes		241 interacting genes: ABCA1 ACBD6 ADAP2 AIP ALK AMMECR1L APRT ARF4 ARF5 ARF6 ARGLU1 ARHGDIA ARL6IP4 ARPP19 AVPI1 BCL10 BIRC2 BRME1 C19orf12 CALB1 CARD10 CARD11 CARD8 CASP6 CASP8 CCHCR1 CDC37 CDK2 CDKN1A CETN3 CHUK CLIC1 CNOT7 COPS3 CPNE2 CREBBP CUEDC1 CWF19L2 CYLD DAPK1 DDIT3 DDX19B DNAJC8 DYNC1LI1 EEF1A1 EGFR EGLN3 EIF1AX ENKD1 EPHA4 FADD FGR FLT3 FLT4 FRMD8 GADD45G GADD45GIP1 GCC1 GEMIN2 GFAP GIT2 GLO1 GNGT1 GPKOW GRK4 GSK3B GTF2E1 GUCY1A1 GYG2 H1-0 HBZ HCLS1 HDDC2 HIF1A HLA-DQA1 HPCAL1 HPD HSP90AA1 HSP90AB1 HSPA1A HSPA4 ID1 ID3 IKBKB INO80E IRAK1 IRAK4 ITK JAK2 JAK3 KANSL2 KIR3DX1 KRT18 KRT8 LCK LENG8 LGALS2 LMCD1 LPXN LUC7L2 LZIC LZTR1 MACROD1 MAFIP MAP3K14 MAP3K2 MAPRE1 MARCHF2 MCM10 MCM7 MED7 MERTK MLLT6 MPRIP MYD88 MYL5 MYO5C MZT2A NAP1L5 NCOA3 NECAB3 NFKB1 NFKB2 NFKBIA NFKBIB NHP2 NRARP NRBF2 NTMT1 ODAM OSBPL10 OSGIN1 PA2G4 PARP1 PCK1 PDCL PFDN5 PHF7 PIM2 PLEKHJ1 PNMA8A POLR2B POLR2D POLR2E POLR3A PPM1B PRKCB PRKCI PRKCQ PRKD3 PRKDC PRKN PRPF18 PSMA3 PSMB5 RAB11A RAB11B RAB8A RALBP1 RBBP8 RBM34 RBM8A RBP1 RET RHOA RIPK1 RIPK2 RNF11 RNF31 RNF34 RNF4 RNF7 ROR2 ROS1 RPL41 RPS12 RPS6KB2 SCLT1 SENP2 SEPTIN9 SGK1 SHTN1 SLU7 SNW1 SRC SRPK1 SSX2IP STK25 STX11 SUPT5H SYT1 TAB1 TAB2 TAB3 TAF7 TANK TARBP2 TAX1BP1 TBC1D7 TBK1 TCEANC TCP10L TCP11 TCP11L1 TEC TEK TMA16 TNF TNFAIP3 TNFRSF1A TNIP1 TNIP2 TPT1 TRAF3IP2 TRIM29 TRIM31 TRIM37 TRIM41 TRIOBP TRPC4AP TSLP TTYH2 TUBG1 TXLNA TYRO3 UBASH3A UBB UBC UBE2D3 UBE2D4 UBE2I USP2 VAMP3 WDR5 WWP1 ZBTB3 ZC3H12A ZFAND5 ZNF587 ZNF835 ZZZ3	29 interacting genes: AKT1 CENPV DLG4 DYRK1A GRIA1 GRIA2 HDAC6 IKBKE IKBKG ITCH KLHL21 MAP3K7 MAPK3 MAPRE1 MIB2 MLKL PLK4 PTPA RIGI RNF166 TBK1 TRAF2 TRAF6 TRAF7 TRAIP TRIM47 TUBA1A UBC UBE2S
Entrez ID		8517	1540
HPRD ID		02217	05427
Ensembl ID		ENSG00000269335	ENSG00000083799
Uniprot IDs		A0A087X1B1 Q9Y6K9	Q9NQC7
PDB IDs		2JVX 2JVY 3BRT 3BRV 3CL3 3FX0 4BWN 5AAY 5LDE 6MI3 6MI4 6XX0 6YEK 7T2U 7TV4 8U7C 9AZJ	1IXD 1WHL 1WHM 2VHF 7OWC 7OWD
Enriched GO Terms of Interacting Partners?		Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Cytoplasm Protein Kinase Activity Non-canonical NF-kappaB Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Cytosol Canonical NF-kappaB Signal Transduction Kinase Activity Regulation Of Immune Response Regulation Of Innate Immune Response Regulation Of Defense Response Activation Of Innate Immune Response Positive Regulation Of Defense Response Positive Regulation Of Signal Transduction Regulation Of Programmed Cell Death Activation Of Immune Response Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune Response Regulation Of Apoptotic Process Positive Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Immune Response-activating Signaling Pathway Protein Modification Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Immune Response-regulating Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Nucleotide Binding Transferase Activity Positive Regulation Of Cell Communication Innate Immune Response-activating Signaling Pathway Macromolecule Metabolic Process Protein Tyrosine Kinase Activity Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Cytokine-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Regulation Of Immune System Process Protein Phosphorylation Protein Binding Regulation Of Protein Modification Process Protein Metabolic Process ATP Binding Negative Regulation Of Programmed Cell Death Phosphorylation Nucleus	Protein Modification Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Transferase Activity Ubiquitin-protein Transferase Activity Post-translational Protein Modification Regulation Of Type I Interferon Production Identical Protein Binding Protein K29-linked Ubiquitination Protein Polyubiquitination Cell Surface Receptor Signaling Pathway Cytosol Cytoplasmic Pattern Recognition Receptor Signaling Pathway Activation Of Innate Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction Cytoplasm Protein Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Activity Protein Serine/threonine Kinase Activity Cytokine-mediated Signaling Pathway Pattern Recognition Receptor Signaling Pathway Regulation Of Protein Metabolic Process Activation Of Immune Response Positive Regulation Of Type I Interferon Production Positive Regulation Of Protein Metabolic Process Innate Immune Response-activating Signaling Pathway Interleukin-17-mediated Signaling Pathway Positive Regulation Of Innate Immune Response Ubiquitin Protein Ligase Binding Positive Regulation Of Defense Response Positive Regulation Of Signal Transduction Positive Regulation Of Macroautophagy Toll-like Receptor 4 Signaling Pathway Regulation Of Macroautophagy Anoikis Positive Regulation Of Immune Response Macromolecule Metabolic Process Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Intracellular Signal Transduction Protein Kinase Activity Programmed Cell Death Immune Response-activating Signaling Pathway Cell Death Intracellular Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Immune Response Positive Regulation Of Cell Communication
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