IKBKG and NFKB2

Number of citations of the paper that reports this interaction (PMID 14743216)
197

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		IKBKG	NFKB2
Gene Name		inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
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Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Spindle Pole Intracellular Nucleus Cytoplasm Cytosol IkappaB Kinase Complex Mitotic Spindle	Nucleus Nucleoplasm Cytoplasm Cytosol Bcl3/NF-kappaB2 Complex
	Molecular Function	Signal Transducer Activity Protein Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Peroxisome Proliferator Activated Receptor Binding Metal Ion Binding Protein Heterodimerization Activity K63-linked Polyubiquitin Binding Linear Polyubiquitin Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding
	Biological Process	Activation Of MAPK Activity B Cell Homeostasis Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Apoptotic Process Inflammatory Response Immune Response Cellular Response To DNA Damage Stimulus I-kappaB Kinase/NF-kappaB Signaling Activation Of NF-kappaB-inducing Kinase Activity JNK Cascade Response To Virus Viral Process Positive Regulation Of Type I Interferon Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Establishment Of Vesicle Localization Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Neuron Death Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Toll-like Receptor Signaling Pathway Follicular Dendritic Cell Differentiation Germinal Center Formation MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Regulation Of Transcription, DNA-templated Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Extracellular Matrix Organization Positive Regulation Of Type I Interferon Production Response To Cytokine Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Spleen Development Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Signaling by the B Cell Receptor (BCR) Downstream TCR signaling Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade IRAK1 recruits IKK complex Downstream signaling events of B Cell Receptor (BCR) Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Innate Immune System activated TAK1 mediates p38 MAPK activation TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade IKK complex recruitment mediated by RIP1 Cytosolic sensors of pathogen-associated DNA Cytokine Signaling in Immune system MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Activation of NF-kappaB in B cells Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Adaptive Immune System	Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Cytokine Signaling in Immune system MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Signaling by Interleukins Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Interleukin-1 processing TRAF6 mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS
Protein-Protein Interactions		225 interactors: ABCA1 ACBD6 ADAP2 AIP ALK AMMECR1L APRT ARF5 ARF6 ARGLU1 ARHGDIA ARL6IP4 ARPP19 ASAP1 AVPI1 BCL10 BIRC2 BIRC3 C19orf12 C19orf57 CALB1 CALCOCO2 CARD10 CARD11 CARD8 CASP6 CASP8 CCHCR1 CDC37 CDK2 CDKN1A CETN3 CHUK CLIC1 CNOT7 COPS3 CPNE2 CREBBP CUEDC1 CYLD DAPK1 DDIT3 DDX19B DNAJC8 DYNC1LI1 EEF1A1 EGLN3 EIF1AX EPHA4 FADD FGR FLT3 FLT4 FRMD8 GADD45G GADD45GIP1 GCC1 GEMIN2 GFAP GIT2 GLO1 GNGT1 GRK4 GSK3B GTF2E1 GUCY1A3 GYG2 H1F0 HBZ HCLS1 HLA-DQA1 HPCAL1 HPD HSP90AA1 HSP90AB1 HSPA1A HSPA4 HTT ID1 ID3 IKBKB INO80E IRAK1 ITK JAK2 JAK3 KANSL2 KIAA1598 KIR3DX1 KRT18 KRT8 LCK LGALS2 LMCD1 LPXN LUC7L2 LZIC LZTR1 MAFIP MALT1 MAP3K14 MAP3K2 MAPRE1 MCM10 MCM7 MED7 MERTK MLLT6 MPRIP MYL5 MYO5C MZT2A NAP1L5 NCOA3 NECAB3 NFKB1 NFKB2 NFKBIA NFKBIB NHP2 NRARP NRBF2 NTMT1 ODAM OSBPL10 PA2G4 PARK2 PARP10 PCK1 PDCL PFDN5 PHF7 PIM2 PLEKHJ1 PNMAL1 POLR2B POLR2D POLR2E POLR3A PPM1B PRKCB PRKCI PRKCQ PRKD3 PSMA3 RAB11A RAB11B RAB11FIP3 RALBP1 RBBP8 RBCK1 RBM34 RBM8A RBP1 RELA RET RHOA RIPK1 RIPK2 RNF11 RNF31 RNF4 RNF7 ROR2 ROS1 RPL41 RPS12 RPS6KB2 SCLT1 SENP2 SEPT9 SGK1 SNW1 SRC SRPK1 SSX2IP STK25 STX11 SUPT5H SYT1 TAB2 TAB3 TAF7 TANK TARBP2 TAX1BP1 TBC1D7 TBK1 TCEANC TCP10L TCP11 TCP11L1 TEC TEK TMA16 TNFAIP3 TNFRSF1A TNIP1 TNIP2 TPT1 TRAF2 TRAF3IP2 TRAF6 TRIM29 TRIM31 TRIM41 TRIOBP TRPC4AP TSLP TTYH2 TUBG1 TXLNA TYRO3 UBB UBC UBE2D3 USP10 USP2 VAMP3 WDR5 WWP1 ZBTB3 ZC3H12A ZFAND5 ZZZ3	35 interactors: BCL3 BTRC CHUK DDX3X DPF2 EPS8 GLG1 GTF2I HDAC4 HDAC5 IKBKB IKBKG MAP3K14 MAP3K8 MEN1 NFKB1 NFKBIA NFKBIB NFKBIE NFKBIZ NKRF NR3C1 NR5A1 PSMD11 REL RELA RELB RPL30 RPL6 RPS13 SIN3A SP1 TNIP2 TSC22D3 USP2
Entrez ID		8517	4791
HPRD ID		02217	01239
Ensembl ID		ENSG00000073009	ENSG00000077150
Uniprot IDs		C9J1R1 Q9Y6K9	Q00653
PDB IDs		2JVX 2JVY 3BRT 3BRV 3CL3 3FX0	1A3Q 2D96 3DO7
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Signaling TRIF-dependent Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Regulation Of Signal Transduction Innate Immune Response-activating Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Activation Of Innate Immune Response Regulation Of Innate Immune Response Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor 4 Signaling Pathway Regulation Of Immune System Process Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Innate Immune Response Regulation Of Apoptotic Process Positive Regulation Of Immune Response Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of Cell Death Positive Regulation Of Immune System Process Negative Regulation Of Programmed Cell Death Regulation Of Metabolic Process Response To Stress Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Metabolic Process Negative Regulation Of Cell Death Regulation Of Cytokine Production Immune System Process Negative Regulation Of Apoptotic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Protein Metabolic Process Response To Stimulus Defense Response Regulation Of Nitrogen Compound Metabolic Process Immune Response Programmed Cell Death Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Apoptotic Process Cellular Response To Stimulus Regulation Of Type I Interferon Production	I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Immune System Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Toll-like Receptor 3 Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Type I Interferon Production Activation Of Innate Immune Response Gene Expression Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor 5 Signaling Pathway RNA Metabolic Process Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Transcription, DNA-templated TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response MyD88-independent Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Pattern Recognition Receptor Signaling Pathway Cellular Macromolecule Biosynthetic Process Innate Immune Response-activating Signal Transduction Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity NIK/NF-kappaB Signaling Macromolecule Biosynthetic Process Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Innate Immune Response Positive Regulation Of Cytokine Production Negative Regulation Of Gene Expression Intracellular Signal Transduction
Tagcloud ?		122c 2012cb944901 9qh azoospermia blimp1 dazl ddx4 declare dppa3 envisioned fam122c funds grants hef ipsc ipscs lin28 poi poi1 poi2 prdm1 q26 rbmx stella sublines talents vasa xq znf	arrangement bcl cbcl cbcls clonal clonality cls ctcl ctcls cutaneous deletions extranodal germline hodgkin ig lymphoid lymphomas lyt malignancies neoplasias nodal oncogenes pathogenetic rearrangement rearrangements southern tal tcr undetectable
Tagcloud (Difference) ?		122c 2012cb944901 9qh azoospermia blimp1 dazl ddx4 declare dppa3 envisioned fam122c funds grants hef ipsc ipscs lin28 poi poi1 poi2 prdm1 q26 rbmx stella sublines talents vasa xq znf	arrangement bcl cbcl cbcls clonal clonality cls ctcl ctcls cutaneous deletions extranodal germline hodgkin ig lymphoid lymphomas lyt malignancies neoplasias nodal oncogenes pathogenetic rearrangement rearrangements southern tal tcr undetectable
Tagcloud (Intersection) ?