IKBKG and POLR2D

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		IKBKG	POLR2D
Description		inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	RNA polymerase II subunit D
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Spindle Pole Nucleus Nucleoplasm Cytoplasm Cytosol IkappaB Kinase Complex Protein-containing Complex Mitotic Spindle	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase II, Core Complex Cytosol Nuclear Speck RNA Polymerase Complex
	Molecular Function	Protein Binding Zinc Ion Binding Protein Domain Specific Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity K63-linked Polyubiquitin Modification-dependent Protein Binding Linear Polyubiquitin Binding Transferrin Receptor Binding	Nucleotide Binding Protein Binding Translation Initiation Factor Binding
	Biological Process	B Cell Homeostasis Regulation Of Transcription By RNA Polymerase II Apoptotic Process Inflammatory Response Immune Response DNA Damage Response Canonical NF-kappaB Signal Transduction Response To Virus Positive Regulation Of Gene Expression Positive Regulation Of Macroautophagy Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Anoikis Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Establishment Of Vesicle Localization Protein-containing Complex Assembly Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	DNA-templated Transcription Initiation Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter
Pathways		Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells ER-Phagosome pathway NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 Downstream TCR signaling FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 SUMOylation of immune response proteins Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway IKBKB deficiency causes SCID IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Ub-specific processing proteases Ovarian tumor domain proteases Interleukin-1 signaling TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 SARS-CoV-2 activates/modulates innate and adaptive immune responses IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Regulation of NF-kappa B signaling PKR-mediated signaling SLC15A4:TASL-dependent IRF5 activation Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Modulation of host responses by IFN-stimulated genes	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere
Drugs		AGRO100 Tarenflurbil
Diseases		Incontinentia pigmenti Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect Osteoporosis, lymphedema, anhydrotic ectodermal dysplasia with immunodeficiency (OLEDAID); Ectodermal dysplasia, anhidrotic, with immunodeficiency, osteopetrosis, and lymphedema
GWAS		Hemoglobin levels ( 26366553)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)
Interacting Genes		241 interacting genes: ABCA1 ACBD6 ADAP2 AIP ALK AMMECR1L APRT ARF4 ARF5 ARF6 ARGLU1 ARHGDIA ARL6IP4 ARPP19 AVPI1 BCL10 BIRC2 BRME1 C19orf12 CALB1 CARD10 CARD11 CARD8 CASP6 CASP8 CCHCR1 CDC37 CDK2 CDKN1A CETN3 CHUK CLIC1 CNOT7 COPS3 CPNE2 CREBBP CUEDC1 CWF19L2 CYLD DAPK1 DDIT3 DDX19B DNAJC8 DYNC1LI1 EEF1A1 EGFR EGLN3 EIF1AX ENKD1 EPHA4 FADD FGR FLT3 FLT4 FRMD8 GADD45G GADD45GIP1 GCC1 GEMIN2 GFAP GIT2 GLO1 GNGT1 GPKOW GRK4 GSK3B GTF2E1 GUCY1A1 GYG2 H1-0 HBZ HCLS1 HDDC2 HIF1A HLA-DQA1 HPCAL1 HPD HSP90AA1 HSP90AB1 HSPA1A HSPA4 ID1 ID3 IKBKB INO80E IRAK1 IRAK4 ITK JAK2 JAK3 KANSL2 KIR3DX1 KRT18 KRT8 LCK LENG8 LGALS2 LMCD1 LPXN LUC7L2 LZIC LZTR1 MACROD1 MAFIP MAP3K14 MAP3K2 MAPRE1 MARCHF2 MCM10 MCM7 MED7 MERTK MLLT6 MPRIP MYD88 MYL5 MYO5C MZT2A NAP1L5 NCOA3 NECAB3 NFKB1 NFKB2 NFKBIA NFKBIB NHP2 NRARP NRBF2 NTMT1 ODAM OSBPL10 OSGIN1 PA2G4 PARP1 PCK1 PDCL PFDN5 PHF7 PIM2 PLEKHJ1 PNMA8A POLR2B POLR2D POLR2E POLR3A PPM1B PRKCB PRKCI PRKCQ PRKD3 PRKDC PRKN PRPF18 PSMA3 PSMB5 RAB11A RAB11B RAB8A RALBP1 RBBP8 RBM34 RBM8A RBP1 RET RHOA RIPK1 RIPK2 RNF11 RNF31 RNF34 RNF4 RNF7 ROR2 ROS1 RPL41 RPS12 RPS6KB2 SCLT1 SENP2 SEPTIN9 SGK1 SHTN1 SLU7 SNW1 SRC SRPK1 SSX2IP STK25 STX11 SUPT5H SYT1 TAB1 TAB2 TAB3 TAF7 TANK TARBP2 TAX1BP1 TBC1D7 TBK1 TCEANC TCP10L TCP11 TCP11L1 TEC TEK TMA16 TNF TNFAIP3 TNFRSF1A TNIP1 TNIP2 TPT1 TRAF3IP2 TRIM29 TRIM31 TRIM37 TRIM41 TRIOBP TRPC4AP TSLP TTYH2 TUBG1 TXLNA TYRO3 UBASH3A UBB UBC UBE2D3 UBE2D4 UBE2I USP2 VAMP3 WDR5 WWP1 ZBTB3 ZC3H12A ZFAND5 ZNF587 ZNF835 ZZZ3	16 interacting genes: ATF7IP EMX1 ESR1 HOXC9 IKBKG NR5A2 POLR2A POLR2B POLR2C POLR2E POLR2G POLR2H POLR2K POLR2L TRIM29 ZSCAN1
Entrez ID		8517	5433
HPRD ID		02217	16191
Ensembl ID		ENSG00000269335	ENSG00000144231
Uniprot IDs		A0A087X1B1 Q9Y6K9	O15514
PDB IDs		2JVX 2JVY 3BRT 3BRV 3CL3 3FX0 4BWN 5AAY 5LDE 6MI3 6MI4 6XX0 6YEK 7T2U 7TV4 8U7C 9AZJ	2C35 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L 6XRE 7LBM 9EHZ 9EI1 9EI3 9EI4
Enriched GO Terms of Interacting Partners?		Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Cytoplasm Protein Kinase Activity Non-canonical NF-kappaB Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Cytosol Canonical NF-kappaB Signal Transduction Kinase Activity Regulation Of Immune Response Regulation Of Innate Immune Response Regulation Of Defense Response Activation Of Innate Immune Response Positive Regulation Of Defense Response Positive Regulation Of Signal Transduction Regulation Of Programmed Cell Death Activation Of Immune Response Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune Response Regulation Of Apoptotic Process Positive Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Immune Response-activating Signaling Pathway Protein Modification Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Immune Response-regulating Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Nucleotide Binding Transferase Activity Positive Regulation Of Cell Communication Innate Immune Response-activating Signaling Pathway Macromolecule Metabolic Process Protein Tyrosine Kinase Activity Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Cytokine-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Regulation Of Immune System Process Protein Phosphorylation Protein Binding Regulation Of Protein Modification Process Protein Metabolic Process ATP Binding Negative Regulation Of Programmed Cell Death Phosphorylation Nucleus	RNA Polymerase II, Core Complex DNA-directed RNA Polymerase Complex DNA-directed RNA Polymerase Activity DNA-templated Transcription Transcription By RNA Polymerase II RNA Polymerase I Complex Nucleobase-containing Compound Biosynthetic Process RNA Polymerase III Complex DNA Binding RNA Metabolic Process Macromolecule Biosynthetic Process Nucleoplasm Nucleic Acid Metabolic Process RNA-directed RNA Polymerase Activity RNA-templated Transcription Regulation Of RNA Metabolic Process Nucleus Transcription By RNA Polymerase III Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Zinc Ion Binding Nucleobase-containing Compound Metabolic Process 5'-3' RNA Polymerase Activity TRNA Transcription By RNA Polymerase III TRNA Transcription Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleolus Sequence-specific Double-stranded DNA Binding Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Ovulation Cycle Process Transcription Coregulator Binding Regulation Of Transcription By RNA Polymerase I Regulation Of Transcription By RNA Polymerase II Zygotic Genome Activation Nuclear Receptor Activity DNA-templated Transcription Elongation Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Glucocorticoid Biosynthetic Process Positive Regulation Of Tendon Cell Differentiation Primary Ovarian Follicle Growth Metal Ion Binding Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Prostate Epithelial Cord Elongation Positive Regulation Of Nitric-oxide Synthase Activity Morula Formation
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