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IKBKG and ALK
Number of citations of the paper that reports this interaction (PubMedID
20098747
)
50
Data Source:
BioGRID
(pull down)
IKBKG
ALK
Description
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
ALK receptor tyrosine kinase
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Spindle Pole
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
IkappaB Kinase Complex
Protein-containing Complex
Mitotic Spindle
Plasma Membrane
Membrane
Protein-containing Complex
Receptor Complex
Extracellular Exosome
Molecular Function
Protein Binding
Zinc Ion Binding
Protein Domain Specific Binding
Polyubiquitin Modification-dependent Protein Binding
Ubiquitin Protein Ligase Binding
Signaling Adaptor Activity
Identical Protein Binding
Protein Homodimerization Activity
Metal Ion Binding
Protein Heterodimerization Activity
K63-linked Polyubiquitin Modification-dependent Protein Binding
Linear Polyubiquitin Binding
Transferrin Receptor Binding
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Heparin Binding
Kinase Activity
Transferase Activity
Receptor Signaling Protein Tyrosine Kinase Activator Activity
Identical Protein Binding
Biological Process
B Cell Homeostasis
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Inflammatory Response
Immune Response
DNA Damage Response
Canonical NF-kappaB Signal Transduction
Response To Virus
Positive Regulation Of Gene Expression
Positive Regulation Of Macroautophagy
Defense Response To Bacterium
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Anoikis
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Establishment Of Vesicle Localization
Protein-containing Complex Assembly
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Response To Stress
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Nervous System Development
Brain Development
Phosphorylation
Hippocampus Development
Adult Behavior
Swimming Behavior
Peptidyl-tyrosine Autophosphorylation
Regulation Of Cell Population Proliferation
Regulation Of Apoptotic Process
Regulation Of Neuron Differentiation
Protein Autophosphorylation
Neuron Development
Negative Regulation Of Lipid Catabolic Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Dopamine Receptor Signaling Pathway
Regulation Of Primary Metabolic Process
Response To Environmental Enrichment
Energy Homeostasis
Positive Regulation Of Dendrite Development
Pathways
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
ER-Phagosome pathway
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
SUMOylation of immune response proteins
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
IKBKB deficiency causes SCID
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Ub-specific processing proteases
Ovarian tumor domain proteases
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
SARS-CoV-2 activates/modulates innate and adaptive immune responses
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Regulation of NF-kappa B signaling
PKR-mediated signaling
SLC15A4:TASL-dependent IRF5 activation
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Modulation of host responses by IFN-stimulated genes
Signaling by ALK
Signaling by ALK
ALK mutants bind TKIs
ASP-3026-resistant ALK mutants
NVP-TAE684-resistant ALK mutants
alectinib-resistant ALK mutants
brigatinib-resistant ALK mutants
ceritinib-resistant ALK mutants
crizotinib-resistant ALK mutants
lorlatinib-resistant ALK mutants
Signaling by ALK fusions and activated point mutants
MDK and PTN in ALK signaling
MDK and PTN in ALK signaling
Drugs
AGRO100
Tarenflurbil
ATP
Crizotinib
Ceritinib
Alectinib
Fostamatinib
Lorlatinib
Gilteritinib
Brigatinib
Diseases
Incontinentia pigmenti
Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect
Osteoporosis, lymphedema, anhydrotic ectodermal dysplasia with immunodeficiency (OLEDAID); Ectodermal dysplasia, anhidrotic, with immunodeficiency, osteopetrosis, and lymphedema
Non-small cell lung cancer
GWAS
Hemoglobin levels (
26366553
)
Adiponectin levels (BMI-adjusted) (
26299439
)
Body mass index (
25673413
)
Body size at age 10 (
32376654
)
Carbamazepine-induced reaction with eosinophilia and systemic symptoms (
31066027
)
Carbamazepine-induced serious cutaneous adverse reaction (
31066027
)
Dentures (
31235808
)
Gestational age at birth (child effect) (
31194736
)
Glucose homeostasis traits (
25524916
)
Low density lipoprotein cholesterol levels (
33339817
)
Number of decayed, missing and filled tooth surfaces or use of dentures (
31235808
)
Pre-treatment viral load in HIV-1 infection (
31219150
)
Simvastatin-induced myopathy (
31220337
)
Spontaneous coronary artery dissection (
32887874
)
Systolic blood pressure (
26969751
)
Total cholesterol levels (
33339817
)
Interacting Genes
241 interacting genes:
ABCA1
ACBD6
ADAP2
AIP
ALK
AMMECR1L
APRT
ARF4
ARF5
ARF6
ARGLU1
ARHGDIA
ARL6IP4
ARPP19
AVPI1
BCL10
BIRC2
BRME1
C19orf12
CALB1
CARD10
CARD11
CARD8
CASP6
CASP8
CCHCR1
CDC37
CDK2
CDKN1A
CETN3
CHUK
CLIC1
CNOT7
COPS3
CPNE2
CREBBP
CUEDC1
CWF19L2
CYLD
DAPK1
DDIT3
DDX19B
DNAJC8
DYNC1LI1
EEF1A1
EGFR
EGLN3
EIF1AX
ENKD1
EPHA4
FADD
FGR
FLT3
FLT4
FRMD8
GADD45G
GADD45GIP1
GCC1
GEMIN2
GFAP
GIT2
GLO1
GNGT1
GPKOW
GRK4
GSK3B
GTF2E1
GUCY1A1
GYG2
H1-0
HBZ
HCLS1
HDDC2
HIF1A
HLA-DQA1
HPCAL1
HPD
HSP90AA1
HSP90AB1
HSPA1A
HSPA4
ID1
ID3
IKBKB
INO80E
IRAK1
IRAK4
ITK
JAK2
JAK3
KANSL2
KIR3DX1
KRT18
KRT8
LCK
LENG8
LGALS2
LMCD1
LPXN
LUC7L2
LZIC
LZTR1
MACROD1
MAFIP
MAP3K14
MAP3K2
MAPRE1
MARCHF2
MCM10
MCM7
MED7
MERTK
MLLT6
MPRIP
MYD88
MYL5
MYO5C
MZT2A
NAP1L5
NCOA3
NECAB3
NFKB1
NFKB2
NFKBIA
NFKBIB
NHP2
NRARP
NRBF2
NTMT1
ODAM
OSBPL10
OSGIN1
PA2G4
PARP1
PCK1
PDCL
PFDN5
PHF7
PIM2
PLEKHJ1
PNMA8A
POLR2B
POLR2D
POLR2E
POLR3A
PPM1B
PRKCB
PRKCI
PRKCQ
PRKD3
PRKDC
PRKN
PRPF18
PSMA3
PSMB5
RAB11A
RAB11B
RAB8A
RALBP1
RBBP8
RBM34
RBM8A
RBP1
RET
RHOA
RIPK1
RIPK2
RNF11
RNF31
RNF34
RNF4
RNF7
ROR2
ROS1
RPL41
RPS12
RPS6KB2
SCLT1
SENP2
SEPTIN9
SGK1
SHTN1
SLU7
SNW1
SRC
SRPK1
SSX2IP
STK25
STX11
SUPT5H
SYT1
TAB1
TAB2
TAB3
TAF7
TANK
TARBP2
TAX1BP1
TBC1D7
TBK1
TCEANC
TCP10L
TCP11
TCP11L1
TEC
TEK
TMA16
TNF
TNFAIP3
TNFRSF1A
TNIP1
TNIP2
TPT1
TRAF3IP2
TRIM29
TRIM31
TRIM37
TRIM41
TRIOBP
TRPC4AP
TSLP
TTYH2
TUBG1
TXLNA
TYRO3
UBASH3A
UBB
UBC
UBE2D3
UBE2D4
UBE2I
USP2
VAMP3
WDR5
WWP1
ZBTB3
ZC3H12A
ZFAND5
ZNF587
ZNF835
ZZZ3
19 interacting genes:
APBB1
DUSP19
ERBB2
HES1
IKBKG
IRS1
JAK3
MDK
NPM1
PIK3R1
PLCG1
PPM1A
PTN
PTPN11
PTPRZ1
SHC1
SHC3
TNFRSF8
ZC3HC1
Entrez ID
8517
238
HPRD ID
02217
00104
Ensembl ID
ENSG00000269335
ENSG00000171094
Uniprot IDs
A0A087X1B1
Q9Y6K9
A0A0K2YUJ3
B6D4Y2
Q9UM73
PDB IDs
2JVX
2JVY
3BRT
3BRV
3CL3
3FX0
4BWN
5AAY
5LDE
6MI3
6MI4
6XX0
6YEK
7T2U
7TV4
8U7C
9AZJ
2KUP
2KUQ
2XB7
2XBA
2XP2
2YFX
2YHV
2YJR
2YJS
2YS5
2YT2
3AOX
3L9P
3LCS
3LCT
4ANL
4ANQ
4ANS
4CCB
4CCU
4CD0
4CLI
4CLJ
4CMO
4CMT
4CMU
4CNH
4CTB
4CTC
4DCE
4FNW
4FNX
4FNY
4FNZ
4FOB
4FOC
4FOD
4JOA
4MKC
4TT7
4Z55
5A9U
5AA8
5AA9
5AAA
5AAB
5AAC
5FTO
5FTQ
5IMX
5IUG
5IUH
5IUI
5KZ0
5VZ5
6AT9
6CDT
6E0R
6EBW
6EDL
6MX8
7BTT
7JY4
7JYR
7JYS
7JYT
7LRZ
7LS0
7MZW
7MZY
7N00
7NWZ
7NX3
7NX4
7R7K
7R7R
8ARJ
9G5I
9GBE
Enriched GO Terms of Interacting Partners
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Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Cytoplasm
Protein Kinase Activity
Non-canonical NF-kappaB Signal Transduction
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Cytosol
Canonical NF-kappaB Signal Transduction
Kinase Activity
Regulation Of Immune Response
Regulation Of Innate Immune Response
Regulation Of Defense Response
Activation Of Innate Immune Response
Positive Regulation Of Defense Response
Positive Regulation Of Signal Transduction
Regulation Of Programmed Cell Death
Activation Of Immune Response
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Immune Response
Regulation Of Apoptotic Process
Positive Regulation Of Signaling
Intracellular Signal Transduction
Positive Regulation Of Innate Immune Response
Immune Response-activating Signaling Pathway
Protein Modification Process
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Immune Response-regulating Signaling Pathway
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Nucleotide Binding
Transferase Activity
Positive Regulation Of Cell Communication
Innate Immune Response-activating Signaling Pathway
Macromolecule Metabolic Process
Protein Tyrosine Kinase Activity
Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Regulation Of Cytokine-mediated Signaling Pathway
Intracellular Receptor Signaling Pathway
Regulation Of Immune System Process
Protein Phosphorylation
Protein Binding
Regulation Of Protein Modification Process
Protein Metabolic Process
ATP Binding
Negative Regulation Of Programmed Cell Death
Phosphorylation
Nucleus
Regulation Of Apoptotic Process
Phosphotyrosine Residue Binding
Regulation Of Programmed Cell Death
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Insulin Receptor Binding
Epidermal Growth Factor Receptor Signaling Pathway
Neurotrophin TRKA Receptor Binding
Negative Regulation Of Apoptotic Process
ERBB Signaling Pathway
Negative Regulation Of Programmed Cell Death
Regulation Of Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Development
Signal Transduction
Positive Regulation Of Gene Expression
Positive Regulation Of Glial Cell Differentiation
Regulation Of Oligodendrocyte Differentiation
Negative Regulation Of Cell Adhesion
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Hemopoiesis
Negative Regulation Of T Cell Differentiation
Insulin-like Growth Factor Receptor Binding
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Lymphocyte Differentiation
Negative Regulation Of T Cell Activation
Receptor Tyrosine Kinase Binding
Leukocyte Activation
Positive Regulation Of Gliogenesis
Intracellular Signal Transduction
Positive Regulation Of Vascular Endothelial Cell Proliferation
Regulation Of Glial Cell Differentiation
Positive Regulation Of Oligodendrocyte Differentiation
Positive Regulation Of Immune System Process
Leukocyte Activation Involved In Immune Response
Negative Regulation Of Leukocyte Cell-cell Adhesion
Cell Activation Involved In Immune Response
Cellular Response To Growth Factor Stimulus
Regulation Of Immune System Process
Negative Regulation Of Lymphocyte Activation
Lymphocyte Activation
Cell Activation
Response To Growth Factor
Negative Regulation Of Cell Differentiation
Regulation Of Multicellular Organismal Development
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Leukocyte Activation
Insulin-like Growth Factor Receptor Signaling Pathway
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