STXBP3 and STX4

Number of citations of the paper that reports this interaction (PubMedID 10194441)
0

Data Source:
HPRD (in vitro)

		STXBP3	STX4
Description		syntaxin binding protein 3	syntaxin 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Secretory Granule Platelet Alpha Granule Specific Granule Phagocytic Vesicle Extracellular Exosome Tertiary Granule Presynapse	Storage Vacuole Extracellular Space Cytoplasm Endosome Vacuole Trans-Golgi Network Cytosol Plasma Membrane Cell Surface Endomembrane System Membrane Basolateral Plasma Membrane Lamellipodium Phagocytic Vesicle Membrane SNARE Complex Stereocilium Neuron Projection Membrane Myelin Sheath Adaxonal Region Somatodendritic Compartment Specific Granule Cell Projection Neuron Projection Dendritic Spine Lateral Loop Synapse Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Schaffer Collateral - CA1 Synapse Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Syntaxin-1 Binding Syntaxin Binding Protein-containing Complex Binding	SNARE Binding SNAP Receptor Activity Protein Binding Sphingomyelin Phosphodiesterase Activator Activity
	Biological Process	Intracellular Glucose Homeostasis Intracellular Protein Transport Exocytosis Vesicle Docking Involved In Exocytosis Response To Stress Immune Response Brain Development Protein Transport Vesicle-mediated Transport Protein To Membrane Docking Insulin Secretion Response To Insulin Neutrophil Degranulation Regulated Exocytosis Negative Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of D-glucose Import Negative Regulation Of Transport Regulation Of Biological Quality Platelet Aggregation Cellular Response To Type II Interferon Presynaptic Dense Core Vesicle Exocytosis	Positive Regulation Of Immunoglobulin Production Neurotransmitter Transport Intracellular Protein Transport Exocytosis Vesicle Fusion Sensory Perception Of Sound Positive Regulation Of Cell Population Proliferation Vesicle-mediated Transport Regulation Of Exocytosis Positive Regulation Of Cell Migration Protein Localization To Cell Surface Cellular Response To Oxidative Stress SNARE Complex Assembly Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Catalytic Activity Positive Regulation Of Eosinophil Degranulation Positive Regulation Of Cell Adhesion Vesicle Docking Organelle Fusion Positive Regulation Of Chemotaxis Long-term Synaptic Potentiation Membrane Organization Cellular Response To Type II Interferon Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein Localization To Plasma Membrane Cornified Envelope Assembly Positive Regulation Of Protein Localization To Cell Surface
Pathways		Disinhibition of SNARE formation Translocation of SLC2A4 (GLUT4) to the plasma membrane	Disinhibition of SNARE formation ER-Phagosome pathway Translocation of SLC2A4 (GLUT4) to the plasma membrane trans-Golgi Network Vesicle Budding Other interleukin signaling
Drugs
Diseases
GWAS		Fat distribution (HIV) ( 21897333)	Response to metformin (IC50) ( 28173075) Triglyceride levels ( 32203549)
Interacting Genes		15 interacting genes: DDX20 GEMIN2 GEMIN4 GEMIN5 PRKCA RPL3 SMN1 SNCA SNRPB SNRPD2 SNRPD3 SNTG1 STX4 STXBP2 VAMP2	65 interacting genes: ABI2 ACTB ANKRD46 BET1 CYBRD1 DLG1 DNAJC5 FAXDC2 GIMAP5 GOSR2 GPR152 ITSN2 LLGL1 LMNA NAPA NAPB NSF PLP1 PSMA3 RAB11A RAB4A RAB5A RNF4 SCRIB SEC22A SEC22B SEPTIN5 SERP1 SGPL1 SH3GLB2 SNAP23 SNAP25 SNAP47 STX10 STX11 STX16 STX1A STX1B STX2 STX3 STX5 STXBP3 STXBP4 STXBP5 STXBP6 SYT1 SYT4 SYT7 TCEANC TMEM203 TRAF3IP3 TXLNA TXLNB TXLNG USE1 VAMP1 VAMP2 VAMP3 VAMP4 VAMP7 VAMP8 VAPB VMA12 VTI1B ZFPL1
Entrez ID		6814	6810
HPRD ID		10517	01722
Ensembl ID		ENSG00000116266	ENSG00000103496
Uniprot IDs		O00186	B7Z425 Q12846
PDB IDs
Enriched GO Terms of Interacting Partners?		SMN-Sm Protein Complex Spliceosomal SnRNP Assembly SMN Complex Gemini Of Cajal Bodies Protein-RNA Complex Assembly RNA Splicing Protein-containing Complex Assembly Spliceosomal Complex Assembly Small Nuclear Ribonucleoprotein Complex MRNA Processing Protein-containing Complex Organization MRNA Metabolic Process RNA Splicing, Via Transesterification Reactions Cellular Component Assembly 7-methylguanosine Cap Hypermethylation U4 SnRNP SNARE Complex Assembly Methylosome RNA Processing Regulation Of Exocytosis Nuclear Body U1 SnRNP U5 SnRNP Cytosol U2-type Prespliceosome Assembly U12-type Spliceosomal Complex U2 SnRNP U2-type Spliceosomal Complex U2-type Catalytic Step 2 Spliceosome Synaptic Vesicle Exocytosis Histone Pre-mRNA DCP Binding U4/U6 X U5 Tri-snRNP Complex RNA Metabolic Process U2-type Precatalytic Spliceosome PICln-Sm Protein Complex Long-term Synaptic Potentiation Spliceosomal Complex U7 SnRNP Neutrophil Degranulation SNARE Binding MRNA Splicing, Via Spliceosome Exocytosis RNA Methylation Positive Regulation Of Exocytosis Catalytic Step 2 Spliceosome Specific Granule Vesicle-mediated Transport In Synapse Response To Cytokine Regulation Of Vesicle-mediated Transport Response To Peptide	SNAP Receptor Activity SNARE Complex Membrane Fusion Syntaxin Binding Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Vesicle-mediated Transport Membrane Organization SNARE Binding Vesicle Organization Exocytosis Organelle Localization By Membrane Tethering Establishment Of Localization In Cell Membrane Docking Secretion By Cell Vesicle Docking Protein Transport Secretion Establishment Of Protein Localization Vesicle-mediated Transport In Synapse Golgi Vesicle Transport Cellular Localization Intracellular Protein Localization Intracellular Transport Organelle Localization Regulation Of Vesicle-mediated Transport Endomembrane System Calcium-ion Regulated Exocytosis SNARE Complex Assembly Membrane Regulated Exocytosis Regulation Of Exocytosis Syntaxin-1 Binding Synaptic Vesicle Exocytosis Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Intracellular Protein Transport Vesicle Fusion To Plasma Membrane Regulation Of Secretion By Cell Synaptic Vesicle Membrane Regulation Of Secretion Synaptic Vesicle Membrane Organization Signal Release Regulation Of Transport Regulation Of Regulated Secretory Pathway Synaptic Vesicle Calcium Ion-regulated Exocytosis Of Neurotransmitter Vesicle Docking Involved In Exocytosis Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Post-Golgi Vesicle-mediated Transport
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