SURF4 and VKORC1

Number of citations of the paper that reports this interaction (PMID 21103663)
2

Data Source:
BioGRID (two hybrid)

		SURF4	VKORC1
Gene Name		surfeit 4	vitamin K epoxide reductase complex, subunit 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Integral Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding	Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Quinone Binding
	Biological Process	Golgi Organization Positive Regulation Of Organelle Organization Protein Exit From Endoplasmic Reticulum Early Endosome To Golgi Transport	Blood Coagulation Drug Metabolic Process Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Oxidation-reduction Process Bone Development
Pathways			Post-translational protein modification Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Drugs			Menadione Dicumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases
GWAS		Activated partial thromboplastin time ( 22703881)	Warfarin maintenance dose ( 18535201 20833655 19300499)
Protein-Protein Interactions		3 interactors: TMEM173 UNC93B1 VKORC1	80 interactors: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5G3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CXADR DPM2 ECHDC1 FGG FGL1 FIS1 FTL GJB1 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 METTL7B MSMO1 MSRB1 MT1X PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC25A1 SLC31A2 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM45B TRAM1 TREX1 VAPB YIF1A ZCCHC24 ZMYM6NB
Entrez ID		6836	79001
HPRD ID		01715	10540
Ensembl ID		ENSG00000148248	ENSG00000167397
Uniprot IDs		B7Z1G8 B7Z6A4 B7Z7A8 O15260	Q9BQB6
PDB IDs
Enriched GO Terms of Interacting Partners?		Activation Of Innate Immune Response Defense Response To Virus Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Toll-like Receptor 7 Signaling Pathway Response To Virus Interferon-beta Production Vitamin K Metabolic Process Cellular Response To Exogenous DsRNA Positive Regulation Of Protein Import Into Nucleus, Translocation Cellular Response To Interferon-beta Peptidyl-glutamic Acid Carboxylation Type I Interferon Production Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Immune Response Regulation Of Protein Import Into Nucleus, Translocation Response To Interferon-beta Response To Other Organism Response To Biotic Stimulus Response To Stress Innate Immune Response Regulation Of Defense Response To Virus By Host Regulation Of Immune Response Positive Regulation Of Immune System Process Cellular Response To DsRNA Quinone Metabolic Process Drug Metabolic Process Positive Regulation Of Transcription Factor Import Into Nucleus Response To Exogenous DsRNA Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Protein Binding Immune Response Regulation Of Immune System Process Defense Response Response To DsRNA Positive Regulation Of Type I Interferon Production Cellular Ketone Metabolic Process Regulation Of Defense Response To Virus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Vitamin Metabolic Process Positive Regulation Of Binding	Cholesterol Metabolic Process Chemical Homeostasis Sterol Metabolic Process Transport Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Phospholipid Efflux Homeostatic Process Steroid Metabolic Process Platelet Degranulation Response To Stress Vesicle-mediated Transport High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Cellular Metal Ion Homeostasis Negative Regulation Of Lipase Activity Cellular Chemical Homeostasis Lipid Metabolic Process Cellular Cation Homeostasis Ion Homeostasis Alcohol Metabolic Process Cellular Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Plasma Lipoprotein Particle Remodeling Platelet Activation Cholesterol Efflux Acute Inflammatory Response Positive Regulation Of Cholesterol Esterification Blood Coagulation Hemostasis Plasma Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Lipid Biosynthetic Process Transition Metal Ion Homeostasis Regulation Of Cholesterol Esterification Negative Regulation Of Cholesterol Transport Acute-phase Response Calcium-mediated Signaling Using Intracellular Calcium Source Lipoprotein Metabolic Process Negative Regulation Of Cholesterol Import Glycerolipid Metabolic Process Defense Response Cell Activation Lipid Homeostasis Reverse Cholesterol Transport Regulation Of Lipid Catabolic Process Regulation Of Cholesterol Import Regulation Of Plasma Lipoprotein Particle Levels Regulation Of Body Fluid Levels Cholesterol Transport
Tagcloud ?			arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd
Tagcloud (Difference) ?			arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd
Tagcloud (Intersection) ?