SUPT6H and DNAJB6

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		SUPT6H	DNAJB6
Description		SPT6 homolog, histone chaperone and transcription elongation factor	DnaJ heat shock protein family (Hsp40) member B6
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Elongation Factor Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Z Disc Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding Protein Binding Nucleosome Binding Histone Binding	ATPase Activator Activity DNA Binding Protein Binding Hsp70 Protein Binding Heat Shock Protein Binding Identical Protein Binding Protein Folding Chaperone Unfolded Protein Binding Protein-folding Chaperone Binding
	Biological Process	Blastocyst Formation Nucleobase-containing Compound Metabolic Process Transcription Elongation By RNA Polymerase II MRNA Processing RNA Splicing Positive Regulation Of Transcription Elongation By RNA Polymerase II Nucleosome Organization Regulation Of Isotype Switching MRNA Transport Regulation Of Muscle Cell Differentiation Transcription Elongation-coupled Chromatin Remodeling	Protein Folding Actin Cytoskeleton Organization Extracellular Matrix Organization Regulation Of Protein Localization Protein Localization To Nucleus Intermediate Filament Organization Negative Regulation Of DNA-templated Transcription Nervous System Process Chorio-allantoic Fusion Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Chorion Development Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation	Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS		Pulse pressure ( 30578418)	Body mass index ( 28552196) Retinal detachment or retinal break ( 31816047) Waist circumference ( 28552196)
Interacting Genes		15 interacting genes: AKT1 CSNK2A1 DNAJB6 EGFR ERBB2 ERCC6 GAB1 HSP90B1 HSPA9 HSPD1 IWS1 MCPH1 RNF10 TCEA1 TSC2	22 interacting genes: ANKRD1 APP ASAP1 BRMS1 CAND2 DYSF KRT18 MAP3K1 MLF1 MRTO4 MYBPC1 MYOM1 PGM1 PIK3CA POLR1D PTEN SGCG SKAP2 SUPT6H TTN TUBGCP3 USP8
Entrez ID		6830	10049
HPRD ID		03211	07107
Ensembl ID		ENSG00000109111	ENSG00000105993
Uniprot IDs		Q7KZ85	A0A0J9YX62 E9PH18 O75190
PDB IDs		6GME 6GMH 6TED 7OOP 7OPC 7OPD 7UNC 7UND 8A3Y 8OEU 8OEV 8OF0 9EGX 9EGY 9EGZ 9EH0 9EH2	6U3R 6U3S 7JSQ 7QBY
Enriched GO Terms of Interacting Partners?		Protein Localization To Organelle Epidermal Growth Factor Receptor Signaling Pathway Intracellular Protein Localization ERBB Signaling Pathway Protein Folding Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Peptidyl-serine Phosphorylation Unfolded Protein Binding Negative Regulation Of Apoptotic Process ATP-dependent Protein Folding Chaperone Negative Regulation Of Programmed Cell Death ATP Binding Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Translational Initiation Positive Regulation Of Cell Growth Response To Epidermal Growth Factor Cellular Localization Positive Regulation Of Toll-like Receptor Signaling Pathway Protein Folding Chaperone ERBB2-EGFR Signaling Pathway Sperm Plasma Membrane Nucleotide Binding Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Double-strand Break Repair Via Classical Nonhomologous End Joining Establishment Of Protein Localization Positive Regulation Of Phosphorylation Positive Regulation Of Growth Anoikis Response To UV-A Nuclear Transport Nucleocytoplasmic Transport Calcium Import Into The Mitochondrion Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cellular Response To Stress Intracellular Protein Transport Protein Tyrosine Kinase Activator Activity Regulation Of Apoptotic Process Regulation Of Translational Initiation Regulation Of RNA Metabolic Process Regulation Of Programmed Cell Death Mitochondrial Calcium Ion Transmembrane Transport Positive Regulation Of Phosphate Metabolic Process Regulation Of Wnt Signaling Pathway Establishment Of Localization In Cell Regulation Of Macromolecule Metabolic Process Establishment Of Protein Localization To Organelle Regulation Of Cell Cycle ERBB2 Signaling Pathway Protein Transport	Sarcomere Organization Response To Mechanical Stimulus M Band Response To Muscle Stretch Actomyosin Structure Organization Positive Regulation Of Amyloid Fibril Formation Cytoskeleton Organization Structural Constituent Of Muscle Structural Molecule Activity Actin Cytoskeleton Organization Protein Kinase A Signaling Titin Binding Cytosol Actin Filament-based Process Regulation Of Amyloid Fibril Formation Positive Regulation Of Protein Localization Positive Regulation Of Protein Transport Myosin Filament Regulation Of Anoikis I Band Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Excitatory Postsynaptic Potential Intracellular Signaling Cassette Reproductive Behavior Organelle Organization Centriolar Satellite Positive Regulation Of Protein Secretion Regulation Of Protein Localization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Actin-mediated Cell Contraction Negative Regulation Of Synaptic Vesicle Clustering Monocyte Activation Involved In Immune Response Cytoplasm
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