SUPT6H and HSP90B1

Number of citations of the paper that reports this interaction (PubMedID 19299420)
73

Data Source:
BioGRID (pull down)

		SUPT6H	HSP90B1
Description		SPT6 homolog, histone chaperone and transcription elongation factor	heat shock protein 90 beta family member 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Elongation Factor Complex	Extracellular Region Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Cytosol Focal Adhesion Membrane Sarcoplasmic Reticulum Midbody Protein-containing Complex Sarcoplasmic Reticulum Lumen Endoplasmic Reticulum Chaperone Complex Melanosome Perinuclear Region Of Cytoplasm Extracellular Exosome Endocytic Vesicle Lumen Sperm Plasma Membrane
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding Protein Binding Nucleosome Binding Histone Binding	Nucleotide Binding RNA Binding Protein Phosphatase Inhibitor Activity Calcium Ion Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein Phosphatase Binding Protein Folding Chaperone Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Blastocyst Formation Nucleobase-containing Compound Metabolic Process Transcription Elongation By RNA Polymerase II MRNA Processing RNA Splicing Positive Regulation Of Transcription Elongation By RNA Polymerase II Nucleosome Organization Regulation Of Isotype Switching MRNA Transport Regulation Of Muscle Cell Differentiation Transcription Elongation-coupled Chromatin Remodeling	Response To Hypoxia Protein Folding Protein Transport Positive Regulation Of Wnt Signaling Pathway Retrograde Protein Transport, ER To Cytosol Actin Rod Assembly Positive Regulation Of Toll-like Receptor Signaling Pathway Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress ERAD Pathway Negative Regulation Of Apoptotic Process Sequestering Of Calcium Ion Cellular Response To Manganese Ion Cellular Response To ATP Protein Localization To Plasma Membrane
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation	Trafficking and processing of endosomal TLR Scavenging by Class A Receptors Scavenging by Class A Receptors ATF6 (ATF6-alpha) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-4 and Interleukin-13 signaling Post-translational protein phosphorylation
Drugs			Rifabutin 2-Chlorodideoxyadenosine Geldanamycin Diglyme N-Ethyl-5'-Carboxamido Adenosine Radicicol METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE Copper
Diseases
GWAS		Pulse pressure ( 30578418)	Metabolite levels ( 23823483) Soluble VCAM-1 levels ( 31217265)
Interacting Genes		15 interacting genes: AKT1 CSNK2A1 DNAJB6 EGFR ERBB2 ERCC6 GAB1 HSP90B1 HSPA9 HSPD1 IWS1 MCPH1 RNF10 TCEA1 TSC2	40 interacting genes: APOB ASGR1 BIRC2 CACYBP CAMLG CSNK2A1 CSNK2A2 CYSLTR2 EGFR ERBB2 ESR1 FANCC GPR37 GRIK1 HSPA13 HSPA9 LINC01554 LRP1 MAPK6 MDM2 MTTP NKX3-1 NR5A2 OGT POLR2E PTEN PTPN11 PVT1 RNF10 RXFP3 SGTB SIRPA SUPT6H TG TLR1 TLR2 TLR4 TP53 TXNDC11 UBASH3A
Entrez ID		6830	7184
HPRD ID		03211	01860
Ensembl ID		ENSG00000109111	ENSG00000166598
Uniprot IDs		Q7KZ85	P14625 V9HWP2
PDB IDs		6GME 6GMH 6TED 7OOP 7OPC 7OPD 7UNC 7UND 8A3Y 8OEU 8OEV 8OF0 9EGX 9EGY 9EGZ 9EH0 9EH2	4NH9 7ULL
Enriched GO Terms of Interacting Partners?		Protein Localization To Organelle Epidermal Growth Factor Receptor Signaling Pathway Intracellular Protein Localization ERBB Signaling Pathway Protein Folding Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Peptidyl-serine Phosphorylation Unfolded Protein Binding Negative Regulation Of Apoptotic Process ATP-dependent Protein Folding Chaperone Negative Regulation Of Programmed Cell Death ATP Binding Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Translational Initiation Positive Regulation Of Cell Growth Response To Epidermal Growth Factor Cellular Localization Positive Regulation Of Toll-like Receptor Signaling Pathway Protein Folding Chaperone ERBB2-EGFR Signaling Pathway Sperm Plasma Membrane Nucleotide Binding Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Double-strand Break Repair Via Classical Nonhomologous End Joining Establishment Of Protein Localization Positive Regulation Of Phosphorylation Positive Regulation Of Growth Anoikis Response To UV-A Nuclear Transport Nucleocytoplasmic Transport Calcium Import Into The Mitochondrion Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cellular Response To Stress Intracellular Protein Transport Protein Tyrosine Kinase Activator Activity Regulation Of Apoptotic Process Regulation Of Translational Initiation Regulation Of RNA Metabolic Process Regulation Of Programmed Cell Death Mitochondrial Calcium Ion Transmembrane Transport Positive Regulation Of Phosphate Metabolic Process Regulation Of Wnt Signaling Pathway Establishment Of Localization In Cell Regulation Of Macromolecule Metabolic Process Establishment Of Protein Localization To Organelle Regulation Of Cell Cycle ERBB2 Signaling Pathway Protein Transport	Receptor Complex Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Developmental Process Negative Regulation Of Proteolysis Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Metabolic Process Rhythmic Process Negative Regulation Of Developmental Process Negative Regulation Of Multicellular Organismal Process Animal Organ Development Heart Development Detection Of Molecule Of Bacterial Origin Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxygen-containing Compound Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Detection Of Triacyl Bacterial Lipopeptide Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Negative Regulation Of Cell Communication Negative Regulation Of Signaling Ubiquitin Protein Ligase Binding Regulation Of Intracellular Signal Transduction Lipoprotein Transport Intracellular Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Protein Catabolic Process Regulation Of Interferon-beta Production Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase CK2 Complex Cellular Response To Actinomycin D Cellular Response To Triacyl Bacterial Lipopeptide Positive Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Regulation Of Protein Catabolic Process Negative Regulation Of Cell Differentiation Regulation Of Signal Transduction Response To Actinomycin D Detection Of Bacterial Lipoprotein Regulation Of Proteolysis ERBB Signaling Pathway Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Identical Protein Binding
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