SUPT6H and TCEA1

Number of citations of the paper that reports this interaction (PubMedID 37696373)
47

Data Source:
BioGRID (pull down)

		SUPT6H	TCEA1
Description		SPT6 homolog, histone chaperone and transcription elongation factor	transcription elongation factor A1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Elongation Factor Complex	Nucleus Nucleoplasm Transcription Factor TFIID Complex Nucleolus
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding Protein Binding Nucleosome Binding Histone Binding	Nucleic Acid Binding DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Blastocyst Formation Nucleobase-containing Compound Metabolic Process Transcription Elongation By RNA Polymerase II MRNA Processing RNA Splicing Positive Regulation Of Transcription Elongation By RNA Polymerase II Nucleosome Organization Regulation Of Isotype Switching MRNA Transport Regulation Of Muscle Cell Differentiation Transcription Elongation-coupled Chromatin Remodeling	DNA-templated Transcription Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Erythrocyte Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation	Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Pulse pressure ( 30578418)	Urinary albumin-to-creatinine ratio ( 26631737)
Interacting Genes		15 interacting genes: AKT1 CSNK2A1 DNAJB6 EGFR ERBB2 ERCC6 GAB1 HSP90B1 HSPA9 HSPD1 IWS1 MCPH1 RNF10 TCEA1 TSC2	20 interacting genes: APP CDC73 CDK7 CEBPA CIRSR CTDP1 CTR9 EAF2 GPKOW GTF2E1 GTF2F2 IWS1 LEO1 PAF1 POLR2A REXO1 RTF1 SKIC8 SUPT6H UBR5
Entrez ID		6830	6917
HPRD ID		03211	03252
Ensembl ID		ENSG00000109111	ENSG00000187735
Uniprot IDs		Q7KZ85	A0A384MTX4 B7Z4W0 P23193
PDB IDs		6GME 6GMH 6TED 7OOP 7OPC 7OPD 7UNC 7UND 8A3Y 8OEU 8OEV 8OF0 9EGX 9EGY 9EGZ 9EH0 9EH2	1TFI 3NDQ 5IY6 5IY7 5IY8 5IYA 5IYB 5IYC 6O9L 6ZUY 6ZV4 7CNF 7UNC 7UND 8A40 8UIS 9EGX 9EGY 9EGZ 9EH0 9EH1 9EH2 9J0N
Enriched GO Terms of Interacting Partners?		Protein Localization To Organelle Epidermal Growth Factor Receptor Signaling Pathway Intracellular Protein Localization ERBB Signaling Pathway Protein Folding Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Peptidyl-serine Phosphorylation Unfolded Protein Binding Negative Regulation Of Apoptotic Process ATP-dependent Protein Folding Chaperone Negative Regulation Of Programmed Cell Death ATP Binding Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Translational Initiation Positive Regulation Of Cell Growth Response To Epidermal Growth Factor Cellular Localization Positive Regulation Of Toll-like Receptor Signaling Pathway Protein Folding Chaperone ERBB2-EGFR Signaling Pathway Sperm Plasma Membrane Nucleotide Binding Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Double-strand Break Repair Via Classical Nonhomologous End Joining Establishment Of Protein Localization Positive Regulation Of Phosphorylation Positive Regulation Of Growth Anoikis Response To UV-A Nuclear Transport Nucleocytoplasmic Transport Calcium Import Into The Mitochondrion Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cellular Response To Stress Intracellular Protein Transport Protein Tyrosine Kinase Activator Activity Regulation Of Apoptotic Process Regulation Of Translational Initiation Regulation Of RNA Metabolic Process Regulation Of Programmed Cell Death Mitochondrial Calcium Ion Transmembrane Transport Positive Regulation Of Phosphate Metabolic Process Regulation Of Wnt Signaling Pathway Establishment Of Localization In Cell Regulation Of Macromolecule Metabolic Process Establishment Of Protein Localization To Organelle Regulation Of Cell Cycle ERBB2 Signaling Pathway Protein Transport	Transcription Elongation By RNA Polymerase II DNA-templated Transcription Elongation RNA Metabolic Process Cdc73/Paf1 Complex Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Endodermal Cell Fate Commitment Nucleobase-containing Compound Biosynthetic Process Cell Fate Commitment Involved In Formation Of Primary Germ Layer Macromolecule Metabolic Process Macromolecule Biosynthetic Process Nucleoplasm Nucleus MRNA Metabolic Process Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Myeloid Cell Differentiation Regulation Of DNA-templated Transcription Elongation Regulation Of RNA Metabolic Process Stem Cell Population Maintenance Maintenance Of Cell Number Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II MRNA Processing Wnt Signaling Pathway Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Cell Fate Commitment Regulation Of Macromolecule Biosynthetic Process RNA 3'-end Processing RNA Processing Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Myeloid Cell Differentiation Positive Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Complex Binding Negative Regulation Of Developmental Process Regulation Of Hemopoiesis Positive Regulation Of Biosynthetic Process Negative Regulation Of Cell Differentiation MRNA 3'-end Processing Positive Regulation Of RNA Metabolic Process Transcription Initiation At RNA Polymerase II Promoter Regulation Of Primary Metabolic Process Regulation Of Cell Differentiation
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