SUPT4H1 and XRCC5

Number of citations of the paper that reports this interaction (PMID 12391174)
24

Data Source:
HPRD (in vitro, in vivo)

		SUPT4H1	XRCC5
Gene Name		suppressor of Ty 4 homolog 1 (S. cerevisiae)	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DSIF Complex	Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytosol Plasma Membrane Membrane Ku70:Ku80 Complex Nonhomologous End Joining Complex
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Heterodimerization Activity	DNA Binding Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding Protein C-terminus Binding Ubiquitin Protein Ligase Binding Telomeric DNA Binding Transcription Regulatory Region DNA Binding Poly(A) RNA Binding 5'-deoxyribose-5-phosphate Lyase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Remodeling Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Gene Expression Viral Process Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription	Telomere Maintenance DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Transcription, DNA-templated Brain Development Cell Proliferation Viral Process Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Response To Drug Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Neurogenesis Hematopoietic Stem Cell Differentiation Cellular Response To Fatty Acid Cellular Hyperosmotic Salinity Response Cellular Response To X-ray Establishment Of Integrated Proviral Latency
Pathways		Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle Pausing and recovery of Tat-mediated HIV elongation Formation of RNA Pol II elongation complex HIV elongation arrest and recovery HIV Life Cycle Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex HIV Transcription Elongation Transcription of the HIV genome RNA Polymerase II Transcription Elongation	Cytosolic sensors of pathogen-associated DNA HIV Infection Processing of DNA ends prior to end rejoining Integration of provirus Early Phase of HIV Life Cycle HIV Life Cycle Nonhomologous End-joining (NHEJ) STING mediated induction of host immune responses Double-Strand Break Repair IRF3-mediated induction of type I IFN 2-LTR circle formation Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: ANXA5 APP EWSR1 HMP19 HTATSF1 LRIF1 PDLIM1 SUPT5H XRCC5	47 interactors: APEX1 APLF AR ATM ATR BAZ1A BRCA1 CD40 CDC16 CEBPA CHAF1A COIL CSNK2A1 ELF3 GZMA GZMB HSF1 LIG3 MSX2 NAA15 NBN NCOA6 NDRG1 ORC2 PARP1 PCNA PDX1 PGR POLA1 POLD1 POLE POLR2A PRKDC RBM14 RUNX2 SGOL1 SUMO1 SUPT4H1 SUPT5H TCF4 TERF2IP TERT TOP2B TYK2 VAV1 WRN XRCC6
Entrez ID		6827	7520
HPRD ID		16026	08935
Ensembl ID		ENSG00000213246	ENSG00000079246
Uniprot IDs		P63272	P13010
PDB IDs		3H7H	1JEQ 1JEY 1Q2Z 1RW2 3RZ9
Enriched GO Terms of Interacting Partners?		Viral Genome Replication Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of DNA-templated Transcription, Elongation Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Gene Expression Regulation Of Metabolic Process Cellular Hyperosmotic Salinity Response Synaptic Growth At Neuromuscular Junction Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Transcription, DNA-templated RNA Biosynthetic Process Viral Process Collateral Sprouting In Absence Of Injury Cellular Response To X-ray Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Cellular Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Viral Life Cycle Nucleobase-containing Compound Metabolic Process Axon Choice Point Recognition Establishment Of Integrated Proviral Latency Heterocycle Metabolic Process Cellular Hyperosmotic Response Hyperosmotic Salinity Response Cellular Aromatic Compound Metabolic Process Neuron Remodeling Establishment Of Viral Latency Cellular Nitrogen Compound Metabolic Process Cellular Response To Salt Stress Hematopoietic Stem Cell Differentiation Positive Regulation Of Macroautophagy Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Response To Abiotic Stimulus Nitrogen Compound Metabolic Process Cellular Copper Ion Homeostasis Negative Regulation Of DNA-templated Transcription, Elongation Double-strand Break Repair Via Nonhomologous End Joining Hyperosmotic Response Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Blood Coagulation Response To Oxidative Stress	DNA Metabolic Process Telomere Maintenance DNA Replication DNA Recombination DNA Repair Cellular Response To DNA Damage Stimulus Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Cellular Response To Stress Double-strand Break Repair Regulation Of Nitrogen Compound Metabolic Process Response To Stress Chromosome Organization Biosynthetic Process DNA-dependent DNA Replication Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Organelle Organization Regulation Of Metabolic Process Cell Cycle Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Cellular Response To Stimulus Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Stimulus Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Mitotic Recombination Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process DNA Strand Elongation Base-excision Repair Transcription From RNA Polymerase II Promoter Cell Cycle Process Negative Regulation Of Biosynthetic Process
Tagcloud ?			annotation bub california cruz databases david deterioration downloaded exploring geo gse27567 h17 hub inheritance mendelian networks omim omnibus ranked santa topological visualization xpc xrcc4 ybx1 yy1 zfhx3 zfp36 zmat3
Tagcloud (Difference) ?			annotation bub california cruz databases david deterioration downloaded exploring geo gse27567 h17 hub inheritance mendelian networks omim omnibus ranked santa topological visualization xpc xrcc4 ybx1 yy1 zfhx3 zfp36 zmat3
Tagcloud (Intersection) ?