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SUPT4H1 and XRCC5
Number of citations of the paper that reports this interaction (PubMedID
12391174
)
76
Data Source:
HPRD
(in vitro, in vivo)
SUPT4H1
XRCC5
Description
SPT4 homolog, DSIF elongation factor subunit
X-ray repair cross complementing 5
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
DSIF Complex
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Extracellular Region
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
Membrane
Small-subunit Processome
Protein-containing Complex
Protein-DNA Complex
Secretory Granule Lumen
Ku70:Ku80 Complex
DNA-dependent Protein Kinase Complex
Nonhomologous End Joining Complex
Site Of DNA Damage
Ribonucleoprotein Complex
Molecular Function
RNA Polymerase II Complex Binding
Protein Binding
Zinc Ion Binding
Metal Ion Binding
Protein Heterodimerization Activity
Nucleotide Binding
Transcription Cis-regulatory Region Binding
DNA Binding
DNA Helicase Activity
Damaged DNA Binding
Double-stranded DNA Binding
Double-stranded Telomeric DNA Binding
RNA Binding
Helicase Activity
Protein Binding
ATP Binding
Enzyme Activator Activity
ATP-dependent Activity, Acting On DNA
Hydrolase Activity
ATP Hydrolysis Activity
Ubiquitin Protein Ligase Binding
U3 SnoRNA Binding
Telomeric DNA Binding
Protein-containing Complex Binding
DNA End Binding
5'-deoxyribose-5-phosphate Lyase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Transcription Elongation By RNA Polymerase II
Negative Regulation Of DNA-templated Transcription, Elongation
Positive Regulation Of DNA-templated Transcription, Elongation
Regulation Of Transcription Elongation By RNA Polymerase II
Negative Regulation Of Transcription Elongation By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase II
Transcription Elongation-coupled Chromatin Remodeling
Telomere Maintenance
Recombinational Repair
Activation Of Innate Immune Response
Immune System Process
DNA Repair
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
DNA Damage Response
Telomere Maintenance Via Telomerase
Negative Regulation Of Macromolecule Biosynthetic Process
Neurogenesis
Regulation Of Telomere Maintenance
Small-subunit Processome Assembly
Ribosome Biogenesis
Innate Immune Response
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of DNA-templated Transcription
Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Neurogenesis
Hematopoietic Stem Cell Differentiation
Protein Localization To Chromosome, Telomeric Region
Hematopoietic Stem Cell Proliferation
Cellular Response To Gamma Radiation
Negative Regulation Of T-circle Formation
Cellular Response To Leukemia Inhibitory Factor
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
RNA Polymerase II Transcription Elongation
2-LTR circle formation
Cytosolic sensors of pathogen-associated DNA
IRF3-mediated induction of type I IFN
Nonhomologous End-Joining (NHEJ)
Neutrophil degranulation
Drugs
Diseases
GWAS
Eosinophil percentage of white cells (
32888494
)
Mental health study participation (completed survey) (
31263887
)
Refractive error (
32231278
)
Interacting Genes
12 interacting genes:
ANXA5
APP
EWSR1
HTATSF1
LRIF1
LRRK2
MFHAS1
NSG2
PDLIM1
SMARCA2
SUPT5H
XRCC5
59 interacting genes:
APEX1
AR
ATM
ATR
BAZ1A
BRCA1
CD40
CDC16
CEBPA
CHAF1A
COIL
CSNK2A1
DEAF1
DUX4
ELF3
ERCC6
GZMA
GZMB
HSF1
HSPB1
LIG3
LINC01554
MSX2
NAA15
NBN
NCOA6
NDRG1
ORC2
PARP1
PCNA
PDX1
PGR
POLA1
POLD1
POLE
POLR2A
PRKDC
PTEN
RBM14
RNF126
RUNX2
SGO1
SRPK2
SUMO2
SUPT4H1
SUPT5H
TCF4
TERF2IP
TERT
TOP1
TOP2B
TYK2
UBC
UBE2I
UCHL3
VAV1
WRN
XRCC6
ZBTB7A
Entrez ID
6827
7520
HPRD ID
16026
08935
Ensembl ID
ENSG00000213246
ENSG00000079246
Uniprot IDs
P63272
P13010
PDB IDs
3H7H
5OIK
6GMH
6GML
6TED
7OKY
7UND
7YCX
8A3Y
8P4C
8P4D
8P4F
8UHA
8UHD
8W8E
8W8F
9EGX
9EGY
9EGZ
9EH0
9EH1
9EH2
9J0N
9J0O
9J0P
1JEQ
1JEY
1Q2Z
1RW2
3RZ9
5Y3R
6ERF
6ERG
6ERH
6ZH6
6ZHA
6ZHE
7AXZ
7K0Y
7K17
7K1J
7K1K
7K1N
7LSY
7LT3
7NFC
7NFE
7SGL
7SU3
7SUD
7Z6O
7Z87
7Z88
7ZT6
7ZVT
7ZWA
7ZYG
8AG4
8AG5
8ASC
8BH3
8BHV
8BHY
8BOT
8EZA
8EZB
8RD4
Enriched GO Terms of Interacting Partners
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Golgi-associated Vesicle
Cellular Response To Catecholamine Stimulus
Cellular Response To Manganese Ion
Response To Catecholamine
Response To Manganese Ion
Positive Regulation Of Defense Response
ATP-dependent Activity, Acting On DNA
Negative Regulation Of Protein Localization To Nucleus
Positive Regulation Of Immune System Process
Amyloid-beta Complex
Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Growth Cone Lamellipodium
Regulation Of Toll-like Receptor Signaling Pathway
Regulation Of Response To Calcium Ion
Positive Regulation Of G Protein-coupled Receptor Signaling Pathway
Lysosome
Amylin Binding
Positive Regulation Of Toll Signaling Pathway
Regulation Of CAMP/PKA Signal Transduction
Modulation Of Excitatory Postsynaptic Potential
Regulation Of Macrophage Activation
Cellular Response To Curcumin
Caveola Neck
GTP-dependent Protein Kinase Activity
Wnt Signalosome Assembly
Regulation Of Cell Activation
Epigenetic Regulation Of Gene Expression
Endothelial Microparticle
Acetylcholine Receptor Activator Activity
PTB Domain Binding
Regulation Of Defense Response
Collateral Sprouting In Absence Of Injury
Regulation Of Protein Import
Protein-containing Complex Organization
Chromatin Organization
Endosome To Plasma Membrane Transport Vesicle
Positive Regulation Of Endothelin Production
Negative Regulation Of Macromolecule Biosynthetic Process
Growth Cone Filopodium
Regulation Of Response To Endoplasmic Reticulum Stress
Regulation Of Calcium-mediated Signaling
Protein-containing Complex Assembly
Lipoprotein Particle
Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Protein Import
Microglia Development
Positive Regulation Of G Protein-coupled Receptor Internalization
DSIF Complex
Small-subunit Processome Assembly
DNA End Binding
DNA Metabolic Process
Nucleic Acid Metabolic Process
Nucleus
Nucleoplasm
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Repair
DNA Damage Response
Macromolecule Metabolic Process
Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Response To Stress
Regulation Of Macromolecule Metabolic Process
Double-strand Break Repair
Positive Regulation Of DNA Metabolic Process
Chromosome, Telomeric Region
Regulation Of DNA Metabolic Process
Telomere Maintenance
Positive Regulation Of Metabolic Process
Regulation Of RNA Biosynthetic Process
DNA Binding
Response To Gamma Radiation
Regulation Of RNA Metabolic Process
Cellular Response To Stress
Double-strand Break Repair Via Nonhomologous End Joining
Positive Regulation Of Macromolecule Biosynthetic Process
Telomere Organization
Regulation Of DNA-templated Transcription
Regulation Of Metabolic Process
Regulation Of DNA Repair
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
DNA Replication
Regulation Of Double-strand Break Repair
Chromatin Binding
Nucleobase-containing Compound Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Chromosome Organization
Positive Regulation Of DNA-templated Transcription
DNA Recombination
Negative Regulation Of DNA Metabolic Process
DNA Strand Elongation
Regulation Of Gene Expression
Recombinational Repair
Response To Ionizing Radiation
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Tagcloud (Intersection)
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