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SUPT4H1 and SUPT5H
Number of citations of the paper that reports this interaction (PubMedID
10454543
)
45
Data Source:
HPRD
(in vitro)
SUPT4H1
SUPT5H
Description
SPT4 homolog, DSIF elongation factor subunit
SPT5 homolog, DSIF elongation factor subunit
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
DSIF Complex
Nucleus
Nucleoplasm
DSIF Complex
Molecular Function
RNA Polymerase II Complex Binding
Protein Binding
Zinc Ion Binding
Metal Ion Binding
Protein Heterodimerization Activity
Chromatin Binding
RNA Binding
MRNA Binding
Protein Binding
Enzyme Binding
Protein Heterodimerization Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Transcription Elongation By RNA Polymerase II
Negative Regulation Of DNA-templated Transcription, Elongation
Positive Regulation Of DNA-templated Transcription, Elongation
Regulation Of Transcription Elongation By RNA Polymerase II
Negative Regulation Of Transcription Elongation By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase II
Transcription Elongation-coupled Chromatin Remodeling
Negative Regulation Of Transcription By RNA Polymerase II
DNA-templated Transcription Elongation
Regulation Of Transcription By RNA Polymerase II
Transcription Elongation By RNA Polymerase II
Positive Regulation Of Macroautophagy
Regulation Of DNA-templated Transcription Elongation
Negative Regulation Of DNA-templated Transcription, Elongation
Positive Regulation Of DNA-templated Transcription, Elongation
Positive Regulation Of Transcription Elongation By RNA Polymerase II
Regulation Of Transcription Elongation By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
RNA Polymerase II Transcription Elongation
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
mRNA Capping
RNA Polymerase II Transcription Elongation
RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases
GWAS
Eosinophil percentage of white cells (
32888494
)
Mental health study participation (completed survey) (
31263887
)
Refractive error (
32231278
)
Neutrophil count (
32888494
)
White blood cell count (
32888494
)
Interacting Genes
12 interacting genes:
ANXA5
APP
EWSR1
HTATSF1
LRIF1
LRRK2
MFHAS1
NSG2
PDLIM1
SMARCA2
SUPT5H
XRCC5
51 interacting genes:
C9orf78
CCNH
CCNT2
CDK7
CDK9
CEP55
CPSF7
CSNK2A1
DBN1
DCAF6
DSCAM
EXOSC7
FHL3
GOLGA2
GTF3C1
H2AX
HSPB1
HTATSF1
IK
IKBKG
LMAN2
MAD1L1
MAML3
MNAT1
PCBD1
PGK1
PHYHIP
PIN1
PNO1
POLR2A
PPIA
PPP2R2D
PRMT1
PRMT5
RPL9
SAP30BP
SIK1
SNRNP48
SNX4
SSBP3
SUMO2
SUPT4H1
TERF1
TEX11
TLE5
XRCC5
YBX2
ZBTB3
ZFYVE9
ZNF496
ZNF512B
Entrez ID
6827
6829
HPRD ID
16026
03655
Ensembl ID
ENSG00000213246
ENSG00000196235
Uniprot IDs
P63272
O00267
PDB IDs
3H7H
5OIK
6GMH
6GML
6TED
7OKY
7UND
7YCX
8A3Y
8P4C
8P4D
8P4F
8UHA
8UHD
8W8E
8W8F
9EGX
9EGY
9EGZ
9EH0
9EH1
9EH2
9J0N
9J0O
9J0P
2DO3
2E6Z
2E70
3H7H
4L1U
5OHO
5OHQ
5OIK
5U98
6EQY
6ER0
6GMH
6GML
6TED
7OKX
7OKY
7OL0
7PKS
7UNC
7UND
7YCX
8A3Y
8P4C
8P4D
8P4E
8P4F
8RBX
8UHA
8UHD
8UHG
8UI0
8UIS
8W8E
8W8F
9EGX
9EGY
9EGZ
9EH0
9EH2
9J0N
9J0O
9J0P
Enriched GO Terms of Interacting Partners
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Golgi-associated Vesicle
Cellular Response To Catecholamine Stimulus
Cellular Response To Manganese Ion
Response To Catecholamine
Response To Manganese Ion
Positive Regulation Of Defense Response
ATP-dependent Activity, Acting On DNA
Negative Regulation Of Protein Localization To Nucleus
Positive Regulation Of Immune System Process
Amyloid-beta Complex
Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Growth Cone Lamellipodium
Regulation Of Toll-like Receptor Signaling Pathway
Regulation Of Response To Calcium Ion
Positive Regulation Of G Protein-coupled Receptor Signaling Pathway
Lysosome
Amylin Binding
Positive Regulation Of Toll Signaling Pathway
Regulation Of CAMP/PKA Signal Transduction
Modulation Of Excitatory Postsynaptic Potential
Regulation Of Macrophage Activation
Cellular Response To Curcumin
Caveola Neck
GTP-dependent Protein Kinase Activity
Wnt Signalosome Assembly
Regulation Of Cell Activation
Epigenetic Regulation Of Gene Expression
Endothelial Microparticle
Acetylcholine Receptor Activator Activity
PTB Domain Binding
Regulation Of Defense Response
Collateral Sprouting In Absence Of Injury
Regulation Of Protein Import
Protein-containing Complex Organization
Chromatin Organization
Endosome To Plasma Membrane Transport Vesicle
Positive Regulation Of Endothelin Production
Negative Regulation Of Macromolecule Biosynthetic Process
Growth Cone Filopodium
Regulation Of Response To Endoplasmic Reticulum Stress
Regulation Of Calcium-mediated Signaling
Protein-containing Complex Assembly
Lipoprotein Particle
Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Protein Import
Microglia Development
Positive Regulation Of G Protein-coupled Receptor Internalization
DSIF Complex
Small-subunit Processome Assembly
DNA End Binding
Nucleus
Nucleic Acid Metabolic Process
Transcription Factor TFIIK Complex
CAK-ERCC2 Complex
Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleoplasm
Nucleobase-containing Compound Metabolic Process
RNA Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cell Cycle Process
Regulation Of Primary Metabolic Process
Regulation Of Cell Cycle
Regulation Of RNA Metabolic Process
DNA-templated Transcription Initiation
Regulation Of Metabolic Process
Positive Regulation Of Metabolic Process
Macromolecule Metabolic Process
Transcription Factor TFIIH Core Complex
Transcription Factor TFIIH Holo Complex
Nucleobase-containing Compound Biosynthetic Process
Regulation Of Gene Expression
Transcription Elongation By RNA Polymerase II
Transcription Initiation At RNA Polymerase II Promoter
Regulation Of Mitotic Cell Cycle
Protein Localization To Chromosome
Regulation Of Macromolecule Metabolic Process
DNA-templated Transcription Elongation
Protein Peptidyl-prolyl Isomerization
Chromosome
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of DNA-templated Transcription, Elongation
Regulation Of Chromosome Segregation
DNA Metabolic Process
Recombinational Repair
Protein Localization To Site Of Double-strand Break
Protein Binding
DNA Recombination
Transcription Pausing By RNA Polymerase II
Postsynaptic Cytosol
Histone H4R3 Methyltransferase Activity
Peptidyl-arginine Methylation
DNA Repair
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Anoikis
Regulation Of Transcription Elongation By RNA Polymerase II
Transcription Elongation-coupled Chromatin Remodeling
Macromolecule Biosynthetic Process
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