SUPT4H1

Description		SPT4 homolog, DSIF elongation factor subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm DSIF Complex
	Molecular Function	RNA Polymerase II Complex Binding Protein Binding Zinc Ion Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Transcription Elongation By RNA Polymerase II Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Transcription Elongation-coupled Chromatin Remodeling
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Eosinophil percentage of white cells ( 32888494) Mental health study participation (completed survey) ( 31263887) Refractive error ( 32231278)
Interacting Genes		12 interacting genes: ANXA5 APP EWSR1 HTATSF1 LRIF1 LRRK2 MFHAS1 NSG2 PDLIM1 SMARCA2 SUPT5H XRCC5
Entrez ID		6827
HPRD ID		16026
Ensembl ID		ENSG00000213246
Uniprot IDs		P63272
PDB IDs		3H7H 5OIK 6GMH 6GML 6TED 7OKY 7UND 7YCX 8A3Y 8P4C 8P4D 8P4F 8UHA 8UHD 8W8E 8W8F 9EGX 9EGY 9EGZ 9EH0 9EH1 9EH2 9J0N 9J0O 9J0P
Enriched GO Terms of Interacting Partners?		Golgi-associated Vesicle Cellular Response To Catecholamine Stimulus Cellular Response To Manganese Ion Response To Catecholamine Response To Manganese Ion Positive Regulation Of Defense Response ATP-dependent Activity, Acting On DNA Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Immune System Process Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Response To Calcium Ion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Lysosome Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Modulation Of Excitatory Postsynaptic Potential Regulation Of Macrophage Activation Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Regulation Of Cell Activation Epigenetic Regulation Of Gene Expression Endothelial Microparticle Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Defense Response Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Protein-containing Complex Organization Chromatin Organization Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Negative Regulation Of Macromolecule Biosynthetic Process Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Calcium-mediated Signaling Protein-containing Complex Assembly Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization DSIF Complex Small-subunit Processome Assembly DNA End Binding
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