SUPT4H1 and HTATSF1

Number of citations of the paper that reports this interaction (PubMedID 10454543)
45

Data Source:
HPRD (in vivo)

		SUPT4H1	HTATSF1
Description		SPT4 homolog, DSIF elongation factor subunit	HIV-1 Tat specific factor 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm DSIF Complex	Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex U2 SnRNP Chromosome Site Of Double-strand Break
	Molecular Function	RNA Polymerase II Complex Binding Protein Binding Zinc Ion Binding Metal Ion Binding Protein Heterodimerization Activity	Nucleic Acid Binding RNA Binding Protein Binding Chromatin-protein Adaptor Activity Poly-ADP-D-ribose Modification-dependent Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Transcription Elongation By RNA Polymerase II Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Transcription Elongation-coupled Chromatin Remodeling	MRNA Splicing, Via Spliceosome Double-strand Break Repair Via Homologous Recombination DNA Repair Chromatin Organization MRNA Processing DNA Damage Response RNA Splicing U2-type Prespliceosome Assembly Protein Localization To Site Of Double-strand Break
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Eosinophil percentage of white cells ( 32888494) Mental health study participation (completed survey) ( 31263887) Refractive error ( 32231278)
Interacting Genes		12 interacting genes: ANXA5 APP EWSR1 HTATSF1 LRIF1 LRRK2 MFHAS1 NSG2 PDLIM1 SMARCA2 SUPT5H XRCC5	21 interacting genes: APBB1 CCNT1 CDK9 CLK1 CSNK2A1 ERCC6 FEZ1 GTF2F2 HDAC6 MAP1LC3A POLR2A RNF10 SF3A2 SNRNP70 SNRPB2 SRPK2 SRSF4 SUPT4H1 SUPT5H WBP4 ZNF512B
Entrez ID		6827	27336
HPRD ID		16026	02282
Ensembl ID		ENSG00000213246	ENSG00000102241
Uniprot IDs		P63272	O43719
PDB IDs		3H7H 5OIK 6GMH 6GML 6TED 7OKY 7UND 7YCX 8A3Y 8P4C 8P4D 8P4F 8UHA 8UHD 8W8E 8W8F 9EGX 9EGY 9EGZ 9EH0 9EH1 9EH2 9J0N 9J0O 9J0P	2DIT 6N3D 6N3E 6N3F 6NSX 6Y50 6Y53 6Y5Q 7EVO 7Q3L 8HK1
Enriched GO Terms of Interacting Partners?		Golgi-associated Vesicle Cellular Response To Catecholamine Stimulus Cellular Response To Manganese Ion Response To Catecholamine Response To Manganese Ion Positive Regulation Of Defense Response ATP-dependent Activity, Acting On DNA Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Immune System Process Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Response To Calcium Ion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Lysosome Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Modulation Of Excitatory Postsynaptic Potential Regulation Of Macrophage Activation Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Regulation Of Cell Activation Epigenetic Regulation Of Gene Expression Endothelial Microparticle Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Defense Response Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Protein-containing Complex Organization Chromatin Organization Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Negative Regulation Of Macromolecule Biosynthetic Process Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Calcium-mediated Signaling Protein-containing Complex Assembly Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization DSIF Complex Small-subunit Processome Assembly DNA End Binding	RNA Metabolic Process DNA-templated Transcription Elongation Nucleic Acid Metabolic Process Transcription Elongation By RNA Polymerase II Nucleoplasm Positive Regulation Of DNA-templated Transcription, Elongation Nucleobase-containing Compound Metabolic Process Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Elongation Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Metabolic Process Nuclear Speck Regulation Of Gene Expression P-TEFb Complex DSIF Complex Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Splicing Negative Regulation Of DNA-templated Transcription, Elongation RNA Splicing RNA Splicing, Via Transesterification Reactions Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Metabolic Process DNA-templated Transcription MRNA Processing Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of MRNA Processing Transcription By RNA Polymerase II Spliceosomal Complex Assembly Transcription Elongation-coupled Chromatin Remodeling U2-type Precatalytic Spliceosome Negative Regulation Of Metabolic Process Cyclin/CDK Positive Transcription Elongation Factor Complex U1 SnRNA Binding Positive Regulation Of Transcription Elongation By RNA Polymerase II 7SK SnRNA Binding Nucleic Acid Binding Positive Regulation Of Metabolic Process Spliceosomal Complex Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Classical Nonhomologous End Joining Regulation Of Autophagy Positive Regulation Of Transcription By RNA Polymerase II SnRNA Binding
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