CENPP and BACH2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CENPP	BACH2
Description		centromere protein P	BACH transcriptional regulator 2
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Inner Kinetochore Nucleus Nucleoplasm Chromosome Nucleolus Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Chromosome Segregation CENP-A Containing Chromatin Assembly	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Import Into Nucleus Primary Adaptive Immune Response Involving T Cells And B Cells
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases			Type I diabetes mellitus
GWAS		End-stage renal disease ( 29885931) HDL cholesterol levels ( 32203549) Height ( 28552196 31562340) Malaria ( 31844061) Pulse pressure ( 30578418) Systolic blood pressure ( 30224653 30578418) Triglyceride levels ( 32203549) Urate levels ( 31578528) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Addison's disease ( 33574239) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Ankylosing spondylitis ( 23749187) Asthma ( 29273806 34103634 32296059 31959851 31619474 31361310 30929738 27182965) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 30929738 31036433) Asthma (moderate or severe) ( 30552067) Asthma onset (childhood vs adult) ( 30929738) Autoimmune thyroid disease ( 32581359) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 31174203 33549134) Basophil count ( 32888494) Celiac disease ( 30572963 20190752 24999842 22057235) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cognitive performance ( 20125193) Crohn's disease ( 28067908 21102463) Cutaneous malignant melanoma ( 32341527) Cutaneous squamous cell carcinoma ( 32041948) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Femur bone mineral density x serum urate levels interaction ( 34046847) General risk tolerance (MTAG) ( 30643258) Graves' disease ( 22922229 21841780) Height ( 28552196) Hip circumference adjusted for BMI ( 28552196) Hypothyroidism ( 27182965) IgG glycosylation ( 23382691) Inflammatory bowel disease ( 28067908) Interleukin-6 levels ( 22205395) Keratinocyte cancer (MTAG) ( 31174203) Latent autoimmune diabetes ( 30254083) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Medication use (thyroid preparations) ( 31015401) Monocyte percentage of white cells ( 32888494 27863252) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244 24076602 21833088) Nasal polyps ( 30643255) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Obesity-related traits ( 23251661) Plateletcrit ( 32888494) Primary central nervous system lymphoma ( 31102405) Primary sclerosing cholangitis ( 27992413 23603763) Red blood cell count ( 32888494) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Rheumatoid arthritis ( 30572963 23143596) Serum urate levels in chronic kidney disease ( 30181573) Squamous cell carcinoma ( 31174203) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 33272962 23273568 27399966) Thyroid peroxidase antibody positivity ( 24586183) Thyroid peroxidase autoantibody levels in type 1 diabetes ( 21829393) Type 1 diabetes ( 19430480 18978792 21829393 30572963 18840781 25751624) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Vitiligo ( 27723757 22561518) White blood cell count ( 32888494 27863252)
Interacting Genes		26 interacting genes: AKAP19 ATP6V0D2 BACH2 CCDC33 CCDC85B CEP44 GOLGA2 HAUS1 KIAA1328 KLC3 LMNA MBD3 NHLH1 NTAQ1 PKNOX2 POLR3K RNF126 RPIA SERTAD3 STXBP1 SYCE1L TEX11 TOX2 USHBP1 ZNF341 ZNF765	45 interacting genes: ANKRD55 AP1M1 BAHD1 BATF3 CBX8 CCDC185 CENPP CFAP58 CTSZ CWF19L2 DDIT3 ELOA ENPP7 FAM161A FARS2 FOSL2 FUS HMG20A INSYN2A KAT5 LUZP4 MAFF MAFK MCRS1 MLX NFE2L1 NFE2L3 NXF1 PATZ1 PSMC5 RPL9 RPP25 SCNM1 SLC43A1 SMYD1 TCEA2 TRAF4 TRIM42 TSHZ2 TULP3 ZBTB24 ZNF124 ZNF438 ZNF774 ZNF792
Entrez ID		401541	60468
HPRD ID		17989	12012
Ensembl ID		ENSG00000188312	ENSG00000112182
Uniprot IDs		Q6IPU0	Q9BYV9
PDB IDs		7PB8 7PKN 7QOO 7R5S 7R5V 7XHN 7XHO 7YWX 7YYH	3OHU 3OHV
Enriched GO Terms of Interacting Partners?		Centrosome Cycle	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription DNA Binding Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Nucleus RNA Polymerase II Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity Negative Regulation Of Macromolecule Metabolic Process Nucleoplasm Protein Binding Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Zinc Ion Binding Chromatin Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Integrated Stress Response Signaling Chromatin Binding Positive Regulation Of DNA Repair Regulation Of Myoblast Differentiation
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