CENPP and NHLH1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		CENPP	NHLH1
Description		centromere protein P	nescient helix-loop-helix 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Inner Kinetochore Nucleus Nucleoplasm Chromosome Nucleolus Cytosol	Chromatin Nucleus
	Molecular Function	Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Chromosome Segregation CENP-A Containing Chromatin Assembly	Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		End-stage renal disease ( 29885931) HDL cholesterol levels ( 32203549) Height ( 28552196 31562340) Malaria ( 31844061) Pulse pressure ( 30578418) Systolic blood pressure ( 30224653 30578418) Triglyceride levels ( 32203549) Urate levels ( 31578528) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		26 interacting genes: AKAP19 ATP6V0D2 BACH2 CCDC33 CCDC85B CEP44 GOLGA2 HAUS1 KIAA1328 KLC3 LMNA MBD3 NHLH1 NTAQ1 PKNOX2 POLR3K RNF126 RPIA SERTAD3 STXBP1 SYCE1L TEX11 TOX2 USHBP1 ZNF341 ZNF765	12 interacting genes: CCT7 CENPP CSRP3 INO80E LMO1 LMO2 LMO4 NFIA NFIB PIM1 PSME2 TCF3
Entrez ID		401541	4807
HPRD ID		17989	01212
Ensembl ID		ENSG00000188312	ENSG00000171786
Uniprot IDs		Q6IPU0	Q02575 Q5T203
PDB IDs		7PB8 7PKN 7QOO 7R5S 7R5V 7XHN 7XHO 7YWX 7YYH
Enriched GO Terms of Interacting Partners?		Centrosome Cycle	Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Neuron Fate Specification Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Glial Cell Fate Specification Nucleoplasm Cell Fate Specification Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Exit From Mitosis Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Generation Of Neurons Regulation Of Macromolecule Biosynthetic Process BHLH Transcription Factor Binding Glial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Lung Ciliated Cell Differentiation Positive Regulation Of Cardioblast Proliferation Positive Regulation Of Actin Filament Severing Regulation Of Gene Expression Positive Regulation Of Telomere Maintenance Retina Development In Camera-type Eye DNA Metabolic Process Cell Differentiation Involved In Salivary Gland Development Negative Regulation Of Mesenchymal Cell Proliferation Involved In Lung Development Negative Regulation Of Actin Filament Severing Nucleus Regulation Of Multicellular Organismal Process Regulation Of Stem Cell Proliferation Regulation Of T Cell Homeostatic Proliferation Neural Precursor Cell Proliferation Principal Sensory Nucleus Of Trigeminal Nerve Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Proteasome Activator Complex Vitamin D Response Element Binding Ventral Spinal Cord Interneuron Differentiation Positive Regulation Of Chromosome Organization
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