PPIA and S100A8

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PPIA	S100A8
Gene Name		peptidylprolyl isomerase A (cyclophilin A)	S100 calcium binding protein A8
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytosol Focal Adhesion Membrane Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Nucleus Cytosol Cytoskeleton Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Peptide Binding Poly(A) RNA Binding Virion Binding Unfolded Protein Binding	Calcium Ion Binding Protein Binding Microtubule Binding Zinc Ion Binding Toll-like Receptor 4 Binding Arachidonic Acid Binding RAGE Receptor Binding
	Biological Process	Protein Peptidyl-prolyl Isomerization Platelet Degranulation RNA-dependent DNA Replication Protein Folding Blood Coagulation Viral Process Viral Life Cycle Uncoating Of Virus Virion Assembly Viral Release From Host Cell Platelet Activation Entry Into Host Cell Lipid Particle Organization Regulation Of Viral Genome Replication Positive Regulation Of Viral Genome Replication Positive Regulation Of Protein Secretion Leukocyte Migration Establishment Of Integrated Proviral Latency	Cytokine Production Leukocyte Migration Involved In Inflammatory Response Acute Inflammatory Response Chronic Inflammatory Response Positive Regulation Of Peptide Secretion Autophagy Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Response To Zinc Ion Positive Regulation Of Cell Growth Neutrophil Chemotaxis Sequestering Of Zinc Ion Response To Lipopolysaccharide Chemokine Production Wound Healing Defense Response To Bacterium Innate Immune Response Response To Ethanol Positive Regulation Of Inflammatory Response Defense Response To Fungus Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cytoskeleton Organization Neutrophil Aggregation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		HIV Infection Host Interactions of HIV factors Integration of provirus Platelet degranulation Basigin interactions Late Phase of HIV Life Cycle Cell surface interactions at the vascular wall Uncoating of the HIV Virion Early Phase of HIV Life Cycle Reverse Transcription of HIV RNA Assembly Of The HIV Virion HIV Life Cycle Budding and maturation of HIV virion Response to elevated platelet cytosolic Ca2+ Minus-strand DNA synthesis Platelet activation, signaling and aggregation Binding and entry of HIV virion Plus-strand DNA synthesis APOBEC3G mediated resistance to HIV-1 infection
Drugs		Cyclosporine L-Proline (3r)-1-Acetyl-3-Methylpiperidine Ethyl Oxo(Piperidin-1-Yl)Acetate (3s,6s,9r,10r,11s,12s,13e,15e,18s,21s)-18-{(1e,3e,7s,8s)-9-[(2s,3r,4s,5s,6r,9s,11s)-9-Ethyl-4-Hydroxy-3,5,11-Trimethyl-8-Oxo-1-Oxa-7-Azaspiro[5.5]Undec-2-Yl]-8-Hydroxy-1,7-Dimethylnona-1,3-Dienyl}-10,12-Dihydroxy-3-(3-Hydroxybenzyl)-6-Isopropyl-11-Methyl-
Diseases
GWAS
Protein-Protein Interactions		22 interactors: APP BSG CD99 ITK JAK2 LIG4 LNX1 NOTCH3 PAXIP1 PRLR PRR13 PRSS23 PTPRN RB1 S100A8 SRPK1 SRPK2 SUPT5H TCF4 TERT USP4 YY1	18 interactors: APP C14orf1 CDKN1A CEACAM3 CHGB GDF9 IGSF21 KLC2 LRIF1 NCF2 PDCD11 PPIA PRMT1 RAB17 S100A9 TP53 TUBA4A UNC119
Entrez ID		5478	6279
HPRD ID		00457	00471
Ensembl ID		ENSG00000196262	ENSG00000143546
Uniprot IDs		P62937 Q567Q0	P05109
PDB IDs		1AK4 1AWQ 1AWR 1AWS 1AWT 1AWU 1AWV 1BCK 1CWA 1CWB 1CWC 1CWF 1CWH 1CWI 1CWJ 1CWK 1CWL 1CWM 1CWO 1FGL 1M63 1M9C 1M9D 1M9E 1M9F 1M9X 1M9Y 1MF8 1MIK 1NMK 1OCA 1RMH 1VBS 1VBT 1W8L 1W8M 1W8V 1YND 1ZKF 2ALF 2CPL 2CYH 2RMA 2RMB 2X25 2X2A 2X2C 2X2D 2XGY 3CYH 3CYS 3K0M 3K0N 3K0O 3K0P 3K0Q 3K0R 3ODI 3ODL 3RDD 4CYH 5CYH	1MR8 1XK4 4GGF
Enriched GO Terms of Interacting Partners?		Chromosome Organization RNA Metabolic Process Activation Of JAK2 Kinase Activity Cellular Metabolic Process Positive Regulation Of Gene Expression Immune System Process RNA Processing Cell Differentiation Positive Regulation Of Metabolic Process Response To Stress Gene Expression Regulation Of Gene Expression Cellular Response To Stimulus Activation Of Janus Kinase Activity Neuron Apoptotic Process Organ Development Regulation Of RNA Metabolic Process DNA Metabolic Process Neuron Death Chromatin Organization Organelle Organization MRNA Processing Nucleobase-containing Compound Metabolic Process Positive Regulation Of Viral Process Response To Stimulus Developmental Process Protein Metabolic Process Positive Regulation Of Peptide Secretion Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Innate Immune Response Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Anatomical Structure Development System Development Regulation Of Nitrogen Compound Metabolic Process Metabolic Process Cellular Nitrogen Compound Metabolic Process Immune Response MRNA Metabolic Process Leukocyte Aggregation Positive Regulation Of Proteolysis Cellular Component Assembly Chromatin Modification Leukocyte Cell-cell Adhesion Positive Regulation Of Viral Genome Replication Regulation Of Sequence-specific DNA Binding Transcription Factor Activity JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Homotypic Cell-cell Adhesion Response To Organic Substance	Blood Coagulation Hemostasis Platelet Degranulation Immune System Process Stress-induced Premature Senescence Regulation Of Body Fluid Levels Wound Healing Regulation Of Growth Mitotic Cell Cycle Arrest Positive Regulation Of Cellular Protein Metabolic Process Response To Light Stimulus Response To Wounding Regulation Of Cell Growth Positive Regulation Of Protein Metabolic Process Immune Response Negative Regulation Of Cell Growth Response To Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Response To X-ray Cellular Senescence Response To Hyperoxia Platelet Activation Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Mitotic Cell Cycle Phase Transition Ras Protein Signal Transduction Positive Regulation Of Cell Cycle Process Regulation Of Protein Phosphorylation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Cell Cycle Phase Transition Response To Stimulus Response To Abiotic Stimulus Positive Regulation Of Programmed Cell Death Axon Cargo Transport Negative Regulation Of Growth Response To Stress Positive Regulation Of Cell Death Response To External Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Neuron Apoptotic Process Cellular Response To Ionizing Radiation Signal Transduction Involved In DNA Damage Checkpoint Positive Regulation Of Neuron Apoptotic Process Signal Transduction Involved In Cell Cycle Checkpoint Cellular Response To UV Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Cycle Negative Regulation Of Clathrin-mediated Endocytosis Uncoating Of Virus Mitotic Cell Cycle Process
Tagcloud ?		ape1 apparently beetroot breaks cdkn2a consumed defenses differing formulations gexp gss hdls ho1 homeostatic il6 interindividual investigates occasions postprandial ptgs2 saturated scope sirt socs3 strand stratified ucp2 unsaturated volunteers	a9 auscan australian canadian erythrocyte esr exploratory grades hand hip inverse joint kellgren knee lawrence mcmaster narrowing oa ontario osteoarthritis osteophytes sedimentation space stiffness structural sum synovial universities womac
Tagcloud (Difference) ?		ape1 apparently beetroot breaks cdkn2a consumed defenses differing formulations gexp gss hdls ho1 homeostatic il6 interindividual investigates occasions postprandial ptgs2 saturated scope sirt socs3 strand stratified ucp2 unsaturated volunteers	a9 auscan australian canadian erythrocyte esr exploratory grades hand hip inverse joint kellgren knee lawrence mcmaster narrowing oa ontario osteoarthritis osteophytes sedimentation space stiffness structural sum synovial universities womac
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