PPIA and YY1

Number of citations of the paper that reports this interaction (PMID 7541038)
23

Data Source:
BioGRID (two hybrid)

		PPIA	YY1
Gene Name		peptidylprolyl isomerase A (cyclophilin A)	YY1 transcription factor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytosol Focal Adhesion Membrane Extracellular Vesicular Exosome	Nucleus Transcription Factor Complex Nuclear Matrix Ino80 Complex PcG Protein Complex
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Peptide Binding Poly(A) RNA Binding Virion Binding Unfolded Protein Binding	Four-way Junction DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Protein Binding Zinc Ion Binding Transcription Regulatory Region DNA Binding
	Biological Process	Protein Peptidyl-prolyl Isomerization Platelet Degranulation RNA-dependent DNA Replication Protein Folding Blood Coagulation Viral Process Viral Life Cycle Uncoating Of Virus Virion Assembly Viral Release From Host Cell Platelet Activation Entry Into Host Cell Lipid Particle Organization Regulation Of Viral Genome Replication Positive Regulation Of Viral Genome Replication Positive Regulation Of Protein Secretion Leukocyte Migration Establishment Of Integrated Proviral Latency	Negative Regulation Of Transcription From RNA Polymerase II Promoter Double-strand Break Repair Via Homologous Recombination Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Localization Cellular Response To DNA Damage Stimulus Spermatogenesis Anterior/posterior Pattern Specification Response To UV-C Positive Regulation Of Gene Expression Cell Differentiation Cellular Response To UV Response To Prostaglandin F Camera-type Eye Morphogenesis Chromosome Organization
Pathways		HIV Infection Host Interactions of HIV factors Integration of provirus Platelet degranulation Basigin interactions Late Phase of HIV Life Cycle Cell surface interactions at the vascular wall Uncoating of the HIV Virion Early Phase of HIV Life Cycle Reverse Transcription of HIV RNA Assembly Of The HIV Virion HIV Life Cycle Budding and maturation of HIV virion Response to elevated platelet cytosolic Ca2+ Minus-strand DNA synthesis Platelet activation, signaling and aggregation Binding and entry of HIV virion Plus-strand DNA synthesis APOBEC3G mediated resistance to HIV-1 infection
Drugs		Cyclosporine L-Proline (3r)-1-Acetyl-3-Methylpiperidine Ethyl Oxo(Piperidin-1-Yl)Acetate (3s,6s,9r,10r,11s,12s,13e,15e,18s,21s)-18-{(1e,3e,7s,8s)-9-[(2s,3r,4s,5s,6r,9s,11s)-9-Ethyl-4-Hydroxy-3,5,11-Trimethyl-8-Oxo-1-Oxa-7-Azaspiro[5.5]Undec-2-Yl]-8-Hydroxy-1,7-Dimethylnona-1,3-Dienyl}-10,12-Dihydroxy-3-(3-Hydroxybenzyl)-6-Isopropyl-11-Methyl-
Diseases
GWAS
Protein-Protein Interactions		22 interactors: APP BSG CD99 ITK JAK2 LIG4 LNX1 NOTCH3 PAXIP1 PRLR PRR13 PRSS23 PTPRN RB1 S100A8 SRPK1 SRPK2 SUPT5H TCF4 TERT USP4 YY1	52 interactors: APP ATF2 ATF6 ATF7 BAP1 BRCA1 CDKN2A CREB1 CRKL E2F2 E2F3 EED EP300 FKBP1A FKBP3 GRN GTF2I HCFC1 HDAC2 HDAC3 HIST1H4A HOXA11 INO80 KAT2B MTA2 MYC NEDD4L NFKB1 NOTCH1 NPM1 NR1H2 PPIA PSMD9 RAF1 RYBP SAP30 SKP2 SLC39A7 SMAD1 SMAD2 SMAD3 SMURF2 SP1 SPRY1 SREBF1 TESK1 TFCP2 TP53 UHRF2 YAF2 ZNF232 ZRANB2
Entrez ID		5478	7528
HPRD ID		00457	02482
Ensembl ID		ENSG00000196262
Uniprot IDs		P62937 Q567Q0	P25490
PDB IDs		1AK4 1AWQ 1AWR 1AWS 1AWT 1AWU 1AWV 1BCK 1CWA 1CWB 1CWC 1CWF 1CWH 1CWI 1CWJ 1CWK 1CWL 1CWM 1CWO 1FGL 1M63 1M9C 1M9D 1M9E 1M9F 1M9X 1M9Y 1MF8 1MIK 1NMK 1OCA 1RMH 1VBS 1VBT 1W8L 1W8M 1W8V 1YND 1ZKF 2ALF 2CPL 2CYH 2RMA 2RMB 2X25 2X2A 2X2C 2X2D 2XGY 3CYH 3CYS 3K0M 3K0N 3K0O 3K0P 3K0Q 3K0R 3ODI 3ODL 3RDD 4CYH 5CYH	1UBD 1ZNM
Enriched GO Terms of Interacting Partners?		Chromosome Organization RNA Metabolic Process Activation Of JAK2 Kinase Activity Cellular Metabolic Process Positive Regulation Of Gene Expression Immune System Process RNA Processing Cell Differentiation Positive Regulation Of Metabolic Process Response To Stress Gene Expression Regulation Of Gene Expression Cellular Response To Stimulus Activation Of Janus Kinase Activity Neuron Apoptotic Process Organ Development Regulation Of RNA Metabolic Process DNA Metabolic Process Neuron Death Chromatin Organization Organelle Organization MRNA Processing Nucleobase-containing Compound Metabolic Process Positive Regulation Of Viral Process Response To Stimulus Developmental Process Protein Metabolic Process Positive Regulation Of Peptide Secretion Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Innate Immune Response Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Anatomical Structure Development System Development Regulation Of Nitrogen Compound Metabolic Process Metabolic Process Cellular Nitrogen Compound Metabolic Process Immune Response MRNA Metabolic Process Leukocyte Aggregation Positive Regulation Of Proteolysis Cellular Component Assembly Chromatin Modification Leukocyte Cell-cell Adhesion Positive Regulation Of Viral Genome Replication Regulation Of Sequence-specific DNA Binding Transcription Factor Activity JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Homotypic Cell-cell Adhesion Response To Organic Substance	Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Gene Expression Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Gene Expression Regulation Of Gene Expression RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle Cellular Response To Growth Factor Stimulus DNA-templated Transcription, Initiation Response To Growth Factor Chromatin Organization Biosynthetic Process Cellular Response To Organic Substance Chromatin Modification Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Process Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Chromosome Organization
Tagcloud ?		ape1 apparently beetroot breaks cdkn2a consumed defenses differing formulations gexp gss hdls ho1 homeostatic il6 interindividual investigates occasions postprandial ptgs2 saturated scope sirt socs3 strand stratified ucp2 unsaturated volunteers	activates activators adenylyl amp cbp clue creb cyclase cyclic depend discuss dissociates e2f1 exactly examples generating homologue implying machinery messenger myb myod neurotransmitter outline phosphorylates pka predisposition superfamily transported
Tagcloud (Difference) ?		ape1 apparently beetroot breaks cdkn2a consumed defenses differing formulations gexp gss hdls ho1 homeostatic il6 interindividual investigates occasions postprandial ptgs2 saturated scope sirt socs3 strand stratified ucp2 unsaturated volunteers	activates activators adenylyl amp cbp clue creb cyclase cyclic depend discuss dissociates e2f1 exactly examples generating homologue implying machinery messenger myb myod neurotransmitter outline phosphorylates pka predisposition superfamily transported
Tagcloud (Intersection) ?