PPIA and NOTCH3

Number of citations of the paper that reports this interaction (PMID 25356737)
0

Data Source:
BioGRID (pull down)

		PPIA	NOTCH3
Gene Name		peptidylprolyl isomerase A (cyclophilin A)	notch 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytosol Focal Adhesion Membrane Extracellular Vesicular Exosome	Golgi Membrane Extracellular Region Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Actin Cytoskeleton Integral Component Of Membrane Receptor Complex
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Peptide Binding Poly(A) RNA Binding Virion Binding Unfolded Protein Binding	Calcium Ion Binding Protein Binding Enzyme Binding
	Biological Process	Protein Peptidyl-prolyl Isomerization Platelet Degranulation RNA-dependent DNA Replication Protein Folding Blood Coagulation Viral Process Viral Life Cycle Uncoating Of Virus Virion Assembly Viral Release From Host Cell Platelet Activation Entry Into Host Cell Lipid Particle Organization Regulation Of Viral Genome Replication Positive Regulation Of Viral Genome Replication Positive Regulation Of Protein Secretion Leukocyte Migration Establishment Of Integrated Proviral Latency	Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Notch Receptor Processing Gene Expression Forebrain Development Negative Regulation Of Neuron Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Glomerular Capillary Formation
Pathways		HIV Infection Host Interactions of HIV factors Integration of provirus Platelet degranulation Basigin interactions Late Phase of HIV Life Cycle Cell surface interactions at the vascular wall Uncoating of the HIV Virion Early Phase of HIV Life Cycle Reverse Transcription of HIV RNA Assembly Of The HIV Virion HIV Life Cycle Budding and maturation of HIV virion Response to elevated platelet cytosolic Ca2+ Minus-strand DNA synthesis Platelet activation, signaling and aggregation Binding and entry of HIV virion Plus-strand DNA synthesis APOBEC3G mediated resistance to HIV-1 infection	Notch-HLH transcription pathway Generic Transcription Pathway Pre-NOTCH Processing in Golgi Pre-NOTCH Transcription and Translation Signaling by NOTCH Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Expression and Processing Signaling by NOTCH3
Drugs		Cyclosporine L-Proline (3r)-1-Acetyl-3-Methylpiperidine Ethyl Oxo(Piperidin-1-Yl)Acetate (3s,6s,9r,10r,11s,12s,13e,15e,18s,21s)-18-{(1e,3e,7s,8s)-9-[(2s,3r,4s,5s,6r,9s,11s)-9-Ethyl-4-Hydroxy-3,5,11-Trimethyl-8-Oxo-1-Oxa-7-Azaspiro[5.5]Undec-2-Yl]-8-Hydroxy-1,7-Dimethylnona-1,3-Dienyl}-10,12-Dihydroxy-3-(3-Hydroxybenzyl)-6-Isopropyl-11-Methyl-
Diseases
GWAS
Protein-Protein Interactions		22 interactors: APP BSG CD99 ITK JAK2 LIG4 LNX1 NOTCH3 PAXIP1 PRLR PRR13 PRSS23 PTPRN RB1 S100A8 SRPK1 SRPK2 SUPT5H TCF4 TERT USP4 YY1	40 interactors: BAG2 BTF3L4 C1QL1 C8orf76 CBFA2T2 CHUK CNTD1 CPNE6 CRIP2 CSNK2B DLL1 EGFL7 FBLN1 GGT6 JAG1 JAG2 KAT2B MAML1 MAML2 MAML3 MPPED2 MYC NEDD9 PPIA PSEN1 PSEN2 RBPJ RET RMI2 SCGB3A1 SLC39A1 SNW1 SNX19 SORBS3 SPTLC2 TMEM108 TNNT2 TPT1 WDR25 XKR8
Entrez ID		5478	4854
HPRD ID		00457	02607
Ensembl ID		ENSG00000196262	ENSG00000074181
Uniprot IDs		P62937 Q567Q0	Q9UM47
PDB IDs		1AK4 1AWQ 1AWR 1AWS 1AWT 1AWU 1AWV 1BCK 1CWA 1CWB 1CWC 1CWF 1CWH 1CWI 1CWJ 1CWK 1CWL 1CWM 1CWO 1FGL 1M63 1M9C 1M9D 1M9E 1M9F 1M9X 1M9Y 1MF8 1MIK 1NMK 1OCA 1RMH 1VBS 1VBT 1W8L 1W8M 1W8V 1YND 1ZKF 2ALF 2CPL 2CYH 2RMA 2RMB 2X25 2X2A 2X2C 2X2D 2XGY 3CYH 3CYS 3K0M 3K0N 3K0O 3K0P 3K0Q 3K0R 3ODI 3ODL 3RDD 4CYH 5CYH
Enriched GO Terms of Interacting Partners?		Chromosome Organization RNA Metabolic Process Activation Of JAK2 Kinase Activity Cellular Metabolic Process Positive Regulation Of Gene Expression Immune System Process RNA Processing Cell Differentiation Positive Regulation Of Metabolic Process Response To Stress Gene Expression Regulation Of Gene Expression Cellular Response To Stimulus Activation Of Janus Kinase Activity Neuron Apoptotic Process Organ Development Regulation Of RNA Metabolic Process DNA Metabolic Process Neuron Death Chromatin Organization Organelle Organization MRNA Processing Nucleobase-containing Compound Metabolic Process Positive Regulation Of Viral Process Response To Stimulus Developmental Process Protein Metabolic Process Positive Regulation Of Peptide Secretion Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Innate Immune Response Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Anatomical Structure Development System Development Regulation Of Nitrogen Compound Metabolic Process Metabolic Process Cellular Nitrogen Compound Metabolic Process Immune Response MRNA Metabolic Process Leukocyte Aggregation Positive Regulation Of Proteolysis Cellular Component Assembly Chromatin Modification Leukocyte Cell-cell Adhesion Positive Regulation Of Viral Genome Replication Regulation Of Sequence-specific DNA Binding Transcription Factor Activity JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Homotypic Cell-cell Adhesion Response To Organic Substance	Notch Signaling Pathway Notch Receptor Processing Transcription Initiation From RNA Polymerase II Promoter Tissue Morphogenesis DNA-templated Transcription, Initiation Morphogenesis Of An Epithelium Tissue Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Epithelium Development Positive Regulation Of Metabolic Process Immune System Development Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression System Development Positive Regulation Of Cellular Biosynthetic Process Multicellular Organismal Development Hemopoiesis Cell Surface Receptor Signaling Pathway Anatomical Structure Development Cell Fate Commitment Developmental Process Tube Development Positive Regulation Of Signal Transduction Cell Differentiation Regulation Of Cell Differentiation Organ Morphogenesis Auditory Receptor Cell Differentiation Heart Morphogenesis Epithelial Tube Morphogenesis Membrane Protein Proteolysis Myeloid Leukocyte Differentiation Positive Regulation Of Transcription Of Notch Receptor Target Hair Cell Differentiation Auditory Receptor Cell Fate Commitment Stem Cell Development Tube Morphogenesis Myoblast Differentiation Cell Development Endothelial Tube Morphogenesis Generation Of Neurons Notch Signaling Involved In Heart Development Amyloid Precursor Protein Catabolic Process Nervous System Development Stem Cell Maintenance Negative Regulation Of Cell Differentiation Stem Cell Differentiation Inner Ear Receptor Cell Differentiation
Tagcloud ?		ape1 apparently beetroot breaks cdkn2a consumed defenses differing formulations gexp gss hdls ho1 homeostatic il6 interindividual investigates occasions postprandial ptgs2 saturated scope sirt socs3 strand stratified ucp2 unsaturated volunteers	barrett cdx1 columnar dnmaml esophagus formerly goblet hes1 jag1 k13 k14 k18 k19 k20 k5 k8 keratins klf4 mastermind metaplasia muc17 muc2 muc3b muc5b mucins organotypic transdifferentiation
Tagcloud (Difference) ?		ape1 apparently beetroot breaks cdkn2a consumed defenses differing formulations gexp gss hdls ho1 homeostatic il6 interindividual investigates occasions postprandial ptgs2 saturated scope sirt socs3 strand stratified ucp2 unsaturated volunteers	barrett cdx1 columnar dnmaml esophagus formerly goblet hes1 jag1 k13 k14 k18 k19 k20 k5 k8 keratins klf4 mastermind metaplasia muc17 muc2 muc3b muc5b mucins organotypic transdifferentiation
Tagcloud (Intersection) ?