SKIL and IL36RN

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		SKIL	IL36RN
Gene Name		SKI-like proto-oncogene	interleukin 36 receptor antagonist
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleoplasm Cytoplasm PML Body Protein Complex	Extracellular Space
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Chromatin Binding Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Protein Complex Binding SMAD Binding	Cytokine Activity Interleukin-1 Receptor Binding Interleukin-1 Receptor Antagonist Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Blastocyst Formation Lymphocyte Homeostasis Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Spermatogenesis Skeletal Muscle Tissue Development Gene Expression Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Cytokine Regulation Of Apoptotic Process Negative Regulation Of Cell Differentiation Response To Antibiotic Positive Regulation Of Axonogenesis Protein Homotrimerization Protein Heterotrimerization Lens Fiber Cell Differentiation Response To Growth Factor Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Negative Regulation Of Cytokine-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Antifungal Humoral Response Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-6 Production Innate Immune Response Negative Regulation Of Interferon-gamma Secretion
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity TGFBR1 LBD Mutants in Cancer Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Loss of Function of TGFBR1 in Cancer Generic Transcription Pathway Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Prostate cancer ( 21743467)
Protein-Protein Interactions		90 interactors: AES ASCC3 C12orf10 CAMSAP1 CBX4 CDC16 CDC27 CHD3 CHPF COL4A2 CPNE1 CPNE2 CPNE4 CXXC5 DHX30 DRG1 EEF1G EIF4G2 ESR1 FAF1 FBLN1 FN1 FZR1 GLUL GOLGB1 HEY1 HEYL HIPK1 HIPK3 IL36RN KRT81 LRP1 MACF1 MORC4 MVP NCOR1 NCOR2 NID1 NID2 NXF3 OIP5 PAPPA PIAS1 PIAS3 PIAS4 PLCD3 PPL PSG3 PSMC2 PTPRF PYCR2 RNF4 RPS27 SASH1 SETDB1 SKI SMAD1 SMAD2 SMAD3 SMAD4 SMURF2 SNRNP70 SNX17 SPARCL1 SRP72 STK16 SVEP1 TDG TDP2 TFPI2 THAP5 THSD7A TPM2 TRAK1 TRIM62 TRIM69 TSKU TTF2 UBE2I UIMC1 USP25 VPS28 XRCC6 ZBTB3 ZBTB6 ZMYM2 ZMYM5 ZNF106 ZNF200 ZZEF1	7 interactors: MCM6 REL SKIL SSBP2 SSBP3 SSBP4 ZNF512B
Entrez ID		6498	26525
HPRD ID		01319	16112
Ensembl ID		ENSG00000136603	ENSG00000136695
Uniprot IDs		P12757	Q9UBH0
PDB IDs		3EQ5
Enriched GO Terms of Interacting Partners?		Gene Expression RNA Biosynthetic Process Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Gene Expression Response To Transforming Growth Factor Beta Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter SMAD Protein Complex Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Protein Modification By Small Protein Conjugation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Protein Sumoylation Nitrogen Compound Metabolic Process Cellular Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cellular Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Primary MiRNA Processing Cell Proliferation Positive Regulation Of Cellular Metabolic Process Protein K11-linked Ubiquitination DNA-templated Transcription, Initiation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transcription From RNA Polymerase II Promoter Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Signaling Regulation Of Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Signaling Gastrulation Proteasomal Protein Catabolic Process	Prechordal Plate Formation Midbrain-hindbrain Boundary Initiation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Anterior Head Development Neural Plate Anterior/posterior Regionalization Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Interleukin-12 Biosynthetic Process Protein Heterotrimerization Midbrain-hindbrain Boundary Development Nitrogen Compound Metabolic Process DNA Unwinding Involved In DNA Replication RNA Metabolic Process Regulation Of Interleukin-12 Biosynthetic Process Protein Homotrimerization Rostrocaudal Neural Tube Patterning Gene Expression Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors DNA Strand Elongation Involved In DNA Replication Regulation Of Transcription From RNA Polymerase II Promoter DNA Strand Elongation Lens Fiber Cell Differentiation DNA Replication Initiation Protein Trimerization Blastocyst Formation Head Morphogenesis NIK/NF-kappaB Signaling Positive Regulation Of Interleukin-12 Production Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Immune System Process Response To Cytokine Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Chordate Embryonic Development Body Morphogenesis
Tagcloud ?		applying associations assuming atm axin1 conserving deleterious endpoints ep300 ercc2 erythema exception gstp1 individually lig4 nos3 nqo1 radiosensitivity snp snps sod2 tgfb tgfb1 unravel weighted xdh xrcc1 xrcc3 xrcc6
Tagcloud (Difference) ?		applying associations assuming atm axin1 conserving deleterious endpoints ep300 ercc2 erythema exception gstp1 individually lig4 nos3 nqo1 radiosensitivity snp snps sod2 tgfb tgfb1 unravel weighted xdh xrcc1 xrcc3 xrcc6
Tagcloud (Intersection) ?