SKIL and MORC4

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SKIL	MORC4
Description		SKI like proto-oncogene	MORC family CW-type zinc finger 4
Image
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm PML Body Protein-containing Complex	Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Protein Domain Specific Binding Identical Protein Binding Protein-containing Complex Binding SMAD Binding	Protein Binding Zinc Ion Binding ATP Hydrolysis Activity Metal Ion Binding Histone H3K4me3 Reader Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blastocyst Formation Lymphocyte Homeostasis Transforming Growth Factor Beta Receptor Signaling Pathway Spermatogenesis Skeletal Muscle Tissue Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Response To Cytokine Negative Regulation Of Cell Differentiation Response To Antibiotic Regulation Of Neurogenesis Positive Regulation Of Axonogenesis Regulation Of Cell Cycle Muscle Structure Development Lens Fiber Cell Differentiation Response To Growth Factor Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Chromatin Organization
Pathways		Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Estimated glomerular filtration rate ( 31152163) Glomerular filtration rate (creatinine) ( 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Prostate cancer ( 21743467)	Alcoholic chronic pancreatitis ( 28754779) Pancreatitis ( 23143602)
Interacting Genes		97 interacting genes: ASCC3 CAMSAP1 CBX4 CDC16 CDC27 CHD3 CHPF COL4A2 CPNE1 CPNE2 CPNE4 CXXC5 DEUP1 DHX30 DRC4 DRG1 DSCAM EEF1G EIF4G2 ESR1 FAF1 FBLN1 FN1 FZR1 GLUL GOLGB1 HEY1 HEYL HIPK1 HIPK3 HNRNPLL IL36RN KRT81 LRP1 MACF1 MORC4 MVP MYG1 NCOR1 NCOR2 NEFL NID1 NID2 NXF3 OIP5 PAPPA PIAS1 PIAS3 PIAS4 PLCD3 PPL PSG3 PSMC2 PTPRF PYCR2 RNF4 RPS27 SASH1 SETDB1 SKI SMAD1 SMAD2 SMAD3 SMAD4 SMUG1 SMURF2 SNRNP70 SNX17 SPARCL1 SRP72 STK16 SVEP1 TDG TDP2 TFPI2 THAP5 THSD7A TLE5 TPM2 TRAK1 TRIM62 TRIM69 TSKU TTF2 UBE2I UIMC1 USP25 VPS28 XPA XRCC6 ZBTB3 ZBTB6 ZMYM2 ZMYM5 ZNF106 ZNF200 ZZEF1	4 interacting genes: GEMIN4 PRKAA1 SKIL STAT3
Entrez ID		6498	79710
HPRD ID		01319	06757
Ensembl ID		ENSG00000136603	ENSG00000133131
Uniprot IDs		P12757	B4DTP6 Q8TE76
PDB IDs		3EQ5 5C4V	7K7T
Enriched GO Terms of Interacting Partners?		PML Body Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process SMAD Protein Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleus Heteromeric SMAD Protein Complex SUMO Transferase Activity Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process SUMO Ligase Activity I-SMAD Binding Collagen Binding Regulation Of Macromolecule Metabolic Process Response To Transforming Growth Factor Beta Regulation Of MiRNA Transcription Protein Metabolic Process Metal Ion Binding Protein Modification By Small Protein Conjugation Nuclear Body Cell Surface Receptor Signaling Pathway Regulation Of Primary Metabolic Process SMAD Protein Signal Transduction Protein Sumoylation Regulation Of MiRNA Metabolic Process Negative Regulation Of MiRNA Transcription Zinc Ion Binding Regulation Of Metabolic Process Cytoplasm Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus SUMO Binding Homomeric SMAD Protein Complex Negative Regulation Of Transforming Growth Factor Beta Production Co-SMAD Binding Regulation Of Gene Expression Regulation Of Developmental Process Extracellular Matrix Structural Constituent Primary MiRNA Processing Positive Regulation Of Protein Sumoylation Regulation Of Protein Catabolic Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cytosol	Regulation Of Glycolytic Process Positive Regulation Of ATP Metabolic Process Regulation Of Carbohydrate Catabolic Process Multicellular Organismal-level Homeostasis Energy Homeostasis Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of Glucosylceramide Biosynthetic Process Transforming Growth Factor Beta Receptor Signaling Pathway Response To Ethanol Protein-containing Complex Regulation Of Generation Of Precursor Metabolites And Energy Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Positive Regulation Of Small Molecule Metabolic Process Cold Acclimation Positive Regulation Of Mitochondrial Transcription Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Carbohydrate Homeostasis Glucose Homeostasis Positive Regulation Of Cellular Component Organization Negative Regulation Of Ceramide Biosynthetic Process Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Sphingolipid Biosynthetic Process CAMP-dependent Protein Kinase Activity Negative Regulation Of Hepatocyte Apoptotic Process Positive Regulation Of Intracellular Signal Transduction AMP-activated Protein Kinase Activity Protein Localization To Lipid Droplet Response To Alcohol CAMKK-AMPK Signaling Cascade Transcription Regulator Complex RNA Sequestering Activity Negative Regulation Of Hydrogen Peroxide Metabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Interleukin-23-mediated Signaling Pathway T-helper 17 Type Immune Response Phosphatidylethanolamine Biosynthetic Process Positive Regulation Of Phosphate Metabolic Process Protein-containing Complex Binding Response To Oxygen Levels Homeostatic Process Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Cellular Response To Hormone Stimulus
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