SKIL and PSMC2

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
HPRD (two hybrid)

		SKIL	PSMC2
Description		SKI like proto-oncogene	proteasome 26S subunit, ATPase 2
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GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm PML Body Protein-containing Complex	Proteasome Complex P-body Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Regulatory Particle, Base Subcomplex Membrane Proteasome Accessory Complex Secretory Granule Lumen Cytoplasmic Ribonucleoprotein Granule Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Protein Domain Specific Binding Identical Protein Binding Protein-containing Complex Binding SMAD Binding	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Proteasome-activating Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blastocyst Formation Lymphocyte Homeostasis Transforming Growth Factor Beta Receptor Signaling Pathway Spermatogenesis Skeletal Muscle Tissue Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Response To Cytokine Negative Regulation Of Cell Differentiation Response To Antibiotic Regulation Of Neurogenesis Positive Regulation Of Axonogenesis Regulation Of Cell Cycle Muscle Structure Development Lens Fiber Cell Differentiation Response To Growth Factor Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Osteoblast Differentiation Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process
Pathways		Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity	Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Neutrophil degranulation Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Estimated glomerular filtration rate ( 31152163) Glomerular filtration rate (creatinine) ( 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Prostate cancer ( 21743467)
Interacting Genes		97 interacting genes: ASCC3 CAMSAP1 CBX4 CDC16 CDC27 CHD3 CHPF COL4A2 CPNE1 CPNE2 CPNE4 CXXC5 DEUP1 DHX30 DRC4 DRG1 DSCAM EEF1G EIF4G2 ESR1 FAF1 FBLN1 FN1 FZR1 GLUL GOLGB1 HEY1 HEYL HIPK1 HIPK3 HNRNPLL IL36RN KRT81 LRP1 MACF1 MORC4 MVP MYG1 NCOR1 NCOR2 NEFL NID1 NID2 NXF3 OIP5 PAPPA PIAS1 PIAS3 PIAS4 PLCD3 PPL PSG3 PSMC2 PTPRF PYCR2 RNF4 RPS27 SASH1 SETDB1 SKI SMAD1 SMAD2 SMAD3 SMAD4 SMUG1 SMURF2 SNRNP70 SNX17 SPARCL1 SRP72 STK16 SVEP1 TDG TDP2 TFPI2 THAP5 THSD7A TLE5 TPM2 TRAK1 TRIM62 TRIM69 TSKU TTF2 UBE2I UIMC1 USP25 VPS28 XPA XRCC6 ZBTB3 ZBTB6 ZMYM2 ZMYM5 ZNF106 ZNF200 ZZEF1	23 interacting genes: CDKN1A CEP55 CNOT7 FILNC1 GTF2B GTF2F1 GTF2H1 NDC80 NDRG1 OGT POLR2M PRKN PSMC1 PSMC4 PSMD2 PSMD5 RPN1 SKIL STUB1 SUMO4 TBP TRAF6 TRIM5
Entrez ID		6498	5701
HPRD ID		01319	01105
Ensembl ID		ENSG00000136603	ENSG00000161057
Uniprot IDs		P12757	A0A140VK70 B7Z571 P35998
PDB IDs		3EQ5 5C4V	5GJQ 5GJR 5L4G 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHJ 5VHM 5VHN 5VHO 5VHP 5VHQ 5VHR 5VHS 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8CVT 8JRI 8JRT 8JTI 8K0G 8USB 8USC 8USD 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q
Enriched GO Terms of Interacting Partners?		PML Body Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process SMAD Protein Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleus Heteromeric SMAD Protein Complex SUMO Transferase Activity Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process SUMO Ligase Activity I-SMAD Binding Collagen Binding Regulation Of Macromolecule Metabolic Process Response To Transforming Growth Factor Beta Regulation Of MiRNA Transcription Protein Metabolic Process Metal Ion Binding Protein Modification By Small Protein Conjugation Nuclear Body Cell Surface Receptor Signaling Pathway Regulation Of Primary Metabolic Process SMAD Protein Signal Transduction Protein Sumoylation Regulation Of MiRNA Metabolic Process Negative Regulation Of MiRNA Transcription Zinc Ion Binding Regulation Of Metabolic Process Cytoplasm Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus SUMO Binding Homomeric SMAD Protein Complex Negative Regulation Of Transforming Growth Factor Beta Production Co-SMAD Binding Regulation Of Gene Expression Regulation Of Developmental Process Extracellular Matrix Structural Constituent Primary MiRNA Processing Positive Regulation Of Protein Sumoylation Regulation Of Protein Catabolic Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cytosol	Proteasome Regulatory Particle, Base Subcomplex Proteasome Accessory Complex Transcription Initiation At RNA Polymerase II Promoter Proteasome Complex DNA-templated Transcription Initiation Protein K63-linked Ubiquitination Nucleus Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Transcription Factor TFIID Complex Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process RNA Polymerase II General Transcription Initiation Factor Activity Proteasome-activating Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process RNA Polymerase II General Transcription Initiation Factor Binding Protein-containing Complex Positive Regulation Of Protein Metabolic Process Macromolecule Metabolic Process Regulation Of Phosphorus Metabolic Process Protein Autoubiquitination Proteasome Regulatory Particle Transcription Preinitiation Complex Regulation Of Protein Ubiquitination Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Ubiquitin-ubiquitin Ligase Activity Regulation Of Phosphorylation DNA-templated Transcription Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Post-translational Protein Modification Positive Regulation Of Macromolecule Metabolic Process Regulation Of Kinase Activity Positive Regulation Of DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Organelle Localization Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Ubiquitination Proteasomal Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Mitophagy Regulation Of Primary Metabolic Process Membraneless Organelle Assembly Macromolecule Biosynthetic Process Protein Polyubiquitination DNA Damage Response Positive Regulation Of Autophagy Of Mitochondrion
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