SKIL and VPS28

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SKIL	VPS28
Gene Name		SKI-like proto-oncogene	vacuolar protein sorting 28 homolog (S. cerevisiae)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleoplasm Cytoplasm PML Body Protein Complex	ESCRT I Complex Cytoplasm Endosome Cytosol Plasma Membrane Endosome Membrane Late Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Chromatin Binding Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Protein Complex Binding SMAD Binding	Protein Binding Protein Complex Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Blastocyst Formation Lymphocyte Homeostasis Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Spermatogenesis Skeletal Muscle Tissue Development Gene Expression Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Cytokine Regulation Of Apoptotic Process Negative Regulation Of Cell Differentiation Response To Antibiotic Positive Regulation Of Axonogenesis Protein Homotrimerization Protein Heterotrimerization Lens Fiber Cell Differentiation Response To Growth Factor Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Viral Process Endosomal Transport Viral Life Cycle Virion Assembly Viral Protein Processing Negative Regulation Of Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Organization Intracellular Transport Of Virus
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity TGFBR1 LBD Mutants in Cancer Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Loss of Function of TGFBR1 in Cancer Generic Transcription Pathway Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer	Assembly Of The HIV Virion Synthesis And Processing Of GAG, GAGPOL Polyproteins HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Membrane binding and targetting of GAG proteins Late Phase of HIV Life Cycle
Drugs
Diseases
GWAS		Prostate cancer ( 21743467)
Protein-Protein Interactions		90 interactors: AES ASCC3 C12orf10 CAMSAP1 CBX4 CDC16 CDC27 CHD3 CHPF COL4A2 CPNE1 CPNE2 CPNE4 CXXC5 DHX30 DRG1 EEF1G EIF4G2 ESR1 FAF1 FBLN1 FN1 FZR1 GLUL GOLGB1 HEY1 HEYL HIPK1 HIPK3 IL36RN KRT81 LRP1 MACF1 MORC4 MVP NCOR1 NCOR2 NID1 NID2 NXF3 OIP5 PAPPA PIAS1 PIAS3 PIAS4 PLCD3 PPL PSG3 PSMC2 PTPRF PYCR2 RNF4 RPS27 SASH1 SETDB1 SKI SMAD1 SMAD2 SMAD3 SMAD4 SMURF2 SNRNP70 SNX17 SPARCL1 SRP72 STK16 SVEP1 TDG TDP2 TFPI2 THAP5 THSD7A TPM2 TRAK1 TRIM62 TRIM69 TSKU TTF2 UBE2I UIMC1 USP25 VPS28 XRCC6 ZBTB3 ZBTB6 ZMYM2 ZMYM5 ZNF106 ZNF200 ZZEF1	27 interactors: ASF1A BLZF1 CARD9 CBX5 FABP3 FAM154A GABARAP GLCCI1 GOLGA2 INCA1 MBIP PDCD6IP PNMA5 RASSF5 SKIL SMN2 TCF12 TCF4 TRIM27 TRIM54 TSG101 UBA52 USHBP1 VPS37A VPS37B VPS37C VPS52
Entrez ID		6498	51160
HPRD ID		01319	11675
Ensembl ID		ENSG00000136603	ENSG00000160948
Uniprot IDs		P12757	Q548N1 Q9UK41
PDB IDs		3EQ5
Enriched GO Terms of Interacting Partners?		Gene Expression RNA Biosynthetic Process Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Gene Expression Response To Transforming Growth Factor Beta Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter SMAD Protein Complex Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Protein Modification By Small Protein Conjugation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Protein Sumoylation Nitrogen Compound Metabolic Process Cellular Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cellular Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Primary MiRNA Processing Cell Proliferation Positive Regulation Of Cellular Metabolic Process Protein K11-linked Ubiquitination DNA-templated Transcription, Initiation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transcription From RNA Polymerase II Promoter Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Signaling Regulation Of Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Signaling Gastrulation Proteasomal Protein Catabolic Process	Virion Assembly Viral Protein Processing Intracellular Transport Of Virus Viral Life Cycle Protein Transport Endosomal Transport Establishment Of Protein Localization Viral Process Protein Localization Membrane Organization Protein Processing Intracellular Transport Regulation Of Extracellular Vesicular Exosome Assembly Viral Budding Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Negative Regulation Of Cell Cycle Establishment Of Localization In Cell Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Gene Expression Negative Regulation Of Transferase Activity Regulation Of Cell Cycle Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Cell Death Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Localization Cell Cycle Arrest Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Protein Trimerization Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Embryonic Digestive Tract Development Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Negative Regulation Of Protein Kinase Activity DNA-templated Transcription, Initiation Transport Negative Regulation Of Gene Expression Muscle Structure Development Negative Regulation Of Biosynthetic Process Negative Regulation Of Kinase Activity Cell Cycle Positive Regulation Of Lipid Biosynthetic Process Glycogen Metabolic Process
Tagcloud ?		applying associations assuming atm axin1 conserving deleterious endpoints ep300 ercc2 erythema exception gstp1 individually lig4 nos3 nqo1 radiosensitivity snp snps sod2 tgfb tgfb1 unravel weighted xdh xrcc1 xrcc3 xrcc6	advancement cd connected counterscreen crohn encodes endosomal immortalized initiating irrespective multidomain nod2 proinflammatory regulators relapsing resource revealing reveals screen secretion sensor sorting strongest subnetworks tnfalpha usp8 validate valuable vesicle
Tagcloud (Difference) ?		applying associations assuming atm axin1 conserving deleterious endpoints ep300 ercc2 erythema exception gstp1 individually lig4 nos3 nqo1 radiosensitivity snp snps sod2 tgfb tgfb1 unravel weighted xdh xrcc1 xrcc3 xrcc6	advancement cd connected counterscreen crohn encodes endosomal immortalized initiating irrespective multidomain nod2 proinflammatory regulators relapsing resource revealing reveals screen secretion sensor sorting strongest subnetworks tnfalpha usp8 validate valuable vesicle
Tagcloud (Intersection) ?