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SKIL and TRIM69
Number of citations of the paper that reports this interaction (PMID
15231748
)
65
Data Source:
HPRD
(two hybrid)
SKIL
TRIM69
Gene Name
SKI-like proto-oncogene
tripartite motif containing 69
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Acrosomal Vesicle
Nucleus
Nucleoplasm
Cytoplasm
PML Body
Protein Complex
Nucleus
Cytoplasm
Plasma Membrane
Nuclear Speck
Molecular Function
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription
DNA Binding
Chromatin Binding
Transcription Corepressor Activity
Protein Binding
Protein Domain Specific Binding
Protein Complex Binding
SMAD Binding
Ubiquitin-protein Transferase Activity
Zinc Ion Binding
Ligase Activity
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Blastocyst Formation
Lymphocyte Homeostasis
Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Cell Cycle Arrest
Transforming Growth Factor Beta Receptor Signaling Pathway
Spermatogenesis
Skeletal Muscle Tissue Development
Gene Expression
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Cytokine
Regulation Of Apoptotic Process
Negative Regulation Of Cell Differentiation
Response To Antibiotic
Positive Regulation Of Axonogenesis
Protein Homotrimerization
Protein Heterotrimerization
Lens Fiber Cell Differentiation
Response To Growth Factor
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Apoptotic Process
Protein Ubiquitination
Pathways
Loss of Function of TGFBR2 in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
Downregulation of SMAD2/3:SMAD4 transcriptional activity
TGFBR1 LBD Mutants in Cancer
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Loss of Function of TGFBR1 in Cancer
Generic Transcription Pathway
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Prostate cancer (
21743467
)
Protein-Protein Interactions
90 interactors:
AES
ASCC3
C12orf10
CAMSAP1
CBX4
CDC16
CDC27
CHD3
CHPF
COL4A2
CPNE1
CPNE2
CPNE4
CXXC5
DHX30
DRG1
EEF1G
EIF4G2
ESR1
FAF1
FBLN1
FN1
FZR1
GLUL
GOLGB1
HEY1
HEYL
HIPK1
HIPK3
IL36RN
KRT81
LRP1
MACF1
MORC4
MVP
NCOR1
NCOR2
NID1
NID2
NXF3
OIP5
PAPPA
PIAS1
PIAS3
PIAS4
PLCD3
PPL
PSG3
PSMC2
PTPRF
PYCR2
RNF4
RPS27
SASH1
SETDB1
SKI
SMAD1
SMAD2
SMAD3
SMAD4
SMURF2
SNRNP70
SNX17
SPARCL1
SRP72
STK16
SVEP1
TDG
TDP2
TFPI2
THAP5
THSD7A
TPM2
TRAK1
TRIM62
TRIM69
TSKU
TTF2
UBE2I
UIMC1
USP25
VPS28
XRCC6
ZBTB3
ZBTB6
ZMYM2
ZMYM5
ZNF106
ZNF200
ZZEF1
22 interactors:
APP
ASNS
ATP5G1
DVL1
FAM110A
FKBP1B
HAUS1
IYD
KRT17
LARP1B
MAGEA4
NEK8
PML
PPP1R18
RECK
RSPH14
SF1
SF3A3
SKIL
SYNE4
TRIM44
ZNF483
Entrez ID
6498
140691
HPRD ID
01319
11518
Ensembl ID
ENSG00000136603
ENSG00000185880
Uniprot IDs
P12757
Q86WT6
PDB IDs
3EQ5
Enriched GO Terms of Interacting Partners
?
Gene Expression
RNA Biosynthetic Process
Transcription, DNA-templated
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
RNA Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Cellular Response To Transforming Growth Factor Beta Stimulus
Negative Regulation Of Gene Expression
Response To Transforming Growth Factor Beta
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Nucleic Acid-templated Transcription
Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Regulation Of Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
SMAD Protein Complex Assembly
Transforming Growth Factor Beta Receptor Signaling Pathway
Protein Modification By Small Protein Conjugation
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Protein Sumoylation
Nitrogen Compound Metabolic Process
Cellular Metabolic Process
Cellular Aromatic Compound Metabolic Process
Transcription Initiation From RNA Polymerase II Promoter
Regulation Of RNA Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Cellular Process
Regulation Of Gene Expression
Regulation Of Transcription, DNA-templated
Primary MiRNA Processing
Cell Proliferation
Positive Regulation Of Cellular Metabolic Process
Protein K11-linked Ubiquitination
DNA-templated Transcription, Initiation
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Transcription From RNA Polymerase II Promoter
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Signaling
Regulation Of Binding
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Signaling
Gastrulation
Proteasomal Protein Catabolic Process
MRNA 3'-splice Site Recognition
Collateral Sprouting
Maintenance Of Protein Location In Nucleus
Anatomical Structure Development
System Development
Negative Regulation Of Catalytic Activity
Protein Localization To Nucleus
Regulation Of Cell Development
Developmental Process
Endoplasmic Reticulum Calcium Ion Homeostasis
Negative Regulation Of Cellular Metabolic Process
Intracellular Receptor Signaling Pathway
Positive Regulation Of Cell Development
Morphogenesis Of An Epithelium
MRNA Splice Site Selection
Multicellular Organismal Development
Organ Development
Positive Regulation Of Neuron Projection Development
Regulation Of Neuron Differentiation
Neuromuscular Junction Development
Cellular Nitrogen Compound Metabolic Process
Epithelium Development
Negative Regulation Of Translation In Response To Oxidative Stress
L-asparagine Biosynthetic Process
Regulation Of Hormone Levels
Anatomical Structure Morphogenesis
Positive Regulation Of Cellular Protein Metabolic Process
Tissue Development
Regulation Of Translation
Spliceosomal Complex Assembly
Positive Regulation Of Cell Projection Organization
Tissue Morphogenesis
Positive Regulation Of Cell Cycle
Regulation Of Proteolysis
Cellular Calcium Ion Homeostasis
Positive Regulation Of Proteolysis
Cell Differentiation
Calcium Ion Homeostasis
Regulation Of Neurogenesis
Positive Regulation Of Protein Metabolic Process
Gene Expression
Cellular Component Assembly
Regulation Of Calcium Ion Transport Into Cytosol
Synaptic Growth At Neuromuscular Junction
Positive Regulation Of Sequestering Of Calcium Ion
Positive Regulation Of Neuron Differentiation
Nitrogen Compound Metabolic Process
Response To Light Stimulus
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Tagcloud
?
applying
associations
assuming
atm
axin1
conserving
deleterious
endpoints
ep300
ercc2
erythema
exception
gstp1
individually
lig4
nos3
nqo1
radiosensitivity
snp
snps
sod2
tgfb
tgfb1
unravel
weighted
xdh
xrcc1
xrcc3
xrcc6
Tagcloud (Difference)
?
applying
associations
assuming
atm
axin1
conserving
deleterious
endpoints
ep300
ercc2
erythema
exception
gstp1
individually
lig4
nos3
nqo1
radiosensitivity
snp
snps
sod2
tgfb
tgfb1
unravel
weighted
xdh
xrcc1
xrcc3
xrcc6
Tagcloud (Intersection)
?