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BRCA1 and BARD1
Number of citations of the paper that reports this interaction (PubMedID
37655321
)
50
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(two hybrid, in vitro, in vivo)
BRCA1
BARD1
Description
BRCA1 DNA repair associated
BRCA1 associated RING domain 1
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nuclear Ubiquitin Ligase Complex
Condensed Chromosome
Condensed Nuclear Chromosome
Lateral Element
Gamma-tubulin Ring Complex
Male Germ Cell Nucleus
XY Body
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Plasma Membrane
Nuclear Body
BRCA1-BARD1 Complex
Protein-containing Complex
BRCA1-A Complex
BRCA1-B Complex
BRCA1-C Complex
DNA Repair Complex
Ribonucleoprotein Complex
Ubiquitin Ligase Complex
Nuclear Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Speck
BRCA1-BARD1 Complex
Cytoplasmic Ribonucleoprotein Granule
BRCA1-A Complex
BRCA1-B Complex
BRCA1-C Complex
Molecular Function
Transcription Cis-regulatory Region Binding
P53 Binding
DNA Binding
Damaged DNA Binding
Transcription Coactivator Activity
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Tubulin Binding
Transferase Activity
Enzyme Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Ubiquitin-modified Histone Reader Activity
RNA Polymerase Binding
Histone H2AK127 Ubiquitin Ligase Activity
Histone H2AK129 Ubiquitin Ligase Activity
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Kinase Binding
Protein Homodimerization Activity
Metal Ion Binding
Protein Heterodimerization Activity
Ubiquitin Protein Ligase Activity
Ubiquitin-modified Histone Reader Activity
Histone H2AK127 Ubiquitin Ligase Activity
Histone H2AK129 Ubiquitin Ligase Activity
Biological Process
Double-strand Break Repair Via Homologous Recombination
DNA Repair
Regulation Of DNA Repair
Postreplication Repair
Double-strand Break Repair
DNA Recombination
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Lipid Metabolic Process
Fatty Acid Metabolic Process
Fatty Acid Biosynthetic Process
DNA Damage Response
Chromosome Segregation
Mitotic G2 DNA Damage Checkpoint Signaling
Centrosome Cycle
Sex-chromosome Dosage Compensation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Ionizing Radiation
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Protein Ubiquitination
Negative Regulation Of Cell Growth
Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Homologous Recombination
Chordate Embryonic Development
Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation
Mitotic G2/M Transition Checkpoint
Negative Regulation Of Fatty Acid Biosynthetic Process
Positive Regulation Of DNA Repair
Positive Regulation Of Angiogenesis
Negative Regulation Of Cell Cycle
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Centriole Replication
Regulation Of Cell Cycle
Protein Autoubiquitination
Random Inactivation Of X Chromosome
Cellular Response To Tumor Necrosis Factor
Cellular Response To Ionizing Radiation
Cellular Response To Indole-3-methanol
Protein K6-linked Ubiquitination
DNA Strand Resection Involved In Replication Fork Processing
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of DNA Damage Checkpoint
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Tissue Homeostasis
DNA Repair
Regulation Of DNA Repair
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
DNA Damage Response
Protein Ubiquitination
Negative Regulation Of MRNA 3'-end Processing
Homologous Recombination
Regulation Of Phosphorylation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Mitotic G2/M Transition Checkpoint
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cell Cycle
Negative Regulation Of Protein Export From Nucleus
Regulation Of Cell Cycle
Cellular Response To Ionizing Radiation
Protein K6-linked Ubiquitination
DNA Strand Resection Involved In Replication Fork Processing
Regulation Of DNA Damage Checkpoint
Pathways
Meiotic synapsis
SUMOylation of DNA damage response and repair proteins
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Metalloprotease DUBs
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
TP53 Regulates Transcription of DNA Repair Genes
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Neddylation
Transcriptional Regulation by E2F6
Meiotic recombination
Defective DNA double strand break response due to BRCA1 loss of function
Defective DNA double strand break response due to BARD1 loss of function
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Impaired BRCA2 binding to RAD51
Impaired BRCA2 binding to PALB2
KEAP1-NFE2L2 pathway
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
UCH proteinases
Metalloprotease DUBs
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Defective DNA double strand break response due to BRCA1 loss of function
Defective DNA double strand break response due to BARD1 loss of function
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Impaired BRCA2 binding to RAD51
Impaired BRCA2 binding to PALB2
Drugs
Diseases
Ovarian cancer
Breast cancer
GWAS
Aspartate aminotransferase levels (
33547301
)
Gynecologic disease (multivariate analysis) (
31488892
)
Menopause (age at onset) (
26414677
29773799
)
Monocyte percentage of white cells (
32888494
)
Ovarian cancer (
31488892
)
Ovarian cancer (MTAG) (
31488892
)
Feeling fed-up (
29500382
)
General risk tolerance (MTAG) (
30643258
)
Neuroblastoma (
21124317
22941191
)
Neuroblastoma (high-risk) (
19412175
)
Neuroblastoma (MYCN amplification) (
28924153
)
Neurociticism (
29500382
)
Sporadic neuroblastoma (
28545128
)
Interacting Genes
323 interacting genes:
ABL1
ABRAXAS1
ACACA
ACTG1
ACTN3
AKT1
ALDH1A1
ANKRD28
ANTXR1
AP1M1
APLP2
AR
ARNT
ASH2L
ATF1
ATM
ATP1B1
ATP1B3
ATR
ATRIP
AURKA
AURKC
BABAM1
BAP1
BARD1
BRAP
BRAT1
BRCA2
BRCC3
BRIP1
BRSK1
CABYR
CASP3
CATSPERT
CAVIN3
CBX1
CBX5
CCDC120
CCNA1
CCNA2
CCNB1
CCND1
CDC25C
CDK1
CDK2
CDK4
CDK7
CDKN2D
CEP57L1
CHEK1
CHEK2
CLSPN
CNRIP1
CNTLN
CNTN4
COL1A1
COMMD1
CREBBP
CRY2
CRYZL1
CSNK1D
CSNK2A1
CSNK2B
CSTF1
CTBP1
CTCFL
CTNNB1
CUBN
CWF19L2
DALRD3
DBF4
DCLRE1C
DCN
DDX24
DES
DHPS
DHX9
DNAJA1
DNAJA3
DNAJB1
DNHD1
DYNC1H1
DYNLT2B
E2F1
E2F4
EED
EIF3B
EIF4A2
EIF5B
ELK1
ELK4
ELOA
ENO1
EP300
ERCC5
ERO1B
ESR1
ETS1
ETV5
EZH2
FAM161A
FAM184A
FANCA
FANCD2
FBXO44
FHL2
FLI1
FLNA
FXR2
GCC1
GFI1B
GGN
GOLGA8DP
GTF3C4
GUSBP1
H2AC20
H2AC4
H2AX
H2BC3
H3C1
HDAC1
HDAC2
HECTD3
HGF
HIBADH
HIVEP1
HNRNPC
HNRNPD
HORMAD1
HSPA14
HSPA8
HSPD1
IFI16
INPP1
ITIH5
ITPR1
ITPRID2
JAK1
JAK2
JUN
JUNB
JUND
JUP
KAT5
KDM1A
KIF1B
KPNA2
KPNA6
LARP7
LCK
LCMT1
LDHC
LMNTD1
LMO4
LONRF1
MACROH2A1
MAN2C1
MAP3K1
MAP3K14
MAP3K3
MAP4K4
MARCKSL1
MDC1
MED1
MED21
MID2
MLH1
MNAT1
MSH2
MSH3
MSH6
MT-ND1
MYC
MYOZ1
NBN
NCOA2
NCOA3
NELFB
NFKB1
NFYA
NKAPL
NMI
NPC2
NRIP1
NSD2
NUFIP1
NUP153
OBSCN
PARG
PEG3
PEX5
PGR
PHF12
PIAS1
PIAS4
PIK3R1
PILRB
PIN1
PISD
POLB
POLR2A
POLR2H
POLR2K
POM121
POMGNT1
POU2F1
PPP1CA
PPP1CB
PPP1R13B
PPP2R5C
PREP
PRKAG3
PRKDC
PRMT1
PRPF3
PSAP
PSMA6
PSMA7
PSMD9
PSMG1
RACK1
RAD51
RANBP9
RB1
RBBP4
RBBP7
RBBP8
RBL1
RBL2
RCC1L
RELA
RFC1
RNF216
RPGRIP1
RPL31
RTKN2
RTL10
RUNX1T1
RWDD2B
RWDD4
SDK2
SETX
SKP2
SMAD2
SMAD3
SMAD4
SMARCA2
SMARCA4
SMC1A
SNRNP200
SNX3
SNX6
SOX30
SP1
SPATA4
SQSTM1
SSX2IP
STAC2
STAT1
STAT3
STAT5A
SUMO1
SYT6
TARS1
TATDN2
TCEA2
TCEANC
TEX101
THOC3
TLE4
TMPRSS12
TNS2
TOP1
TOP2A
TOP2B
TP53
TP53BP1
TPTE2
TRIM24
TRIM46
TRIM47
TRIM74
TRRAP
TSEN54
TSGA10IP
TUBA4A
TUBB
TUBG1
TULP2
TXLNA
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2J1
UBE2K
UBE2L3
UBE2N
UBE2T
UBE2W
UBE3A
UBXN1
USF2
USH2A
USP2
VCP
VHL
WDR6
WNT2B
WRN
XAF1
XIAP
XRCC1
XRCC5
YY1
ZNF280D
ZNF350
ZNF423
ZSCAN21
131 interacting genes:
ACP1
AKIP1
AP1B1
ASH2L
ATP1B1
ATP1B3
AXIN2
BCCIP
BCL3
BGLT3
BRCA1
BRD7
CAP1
CBX1
CBX3
CBX5
CCDC136
CDK1
CDK2
CEP70
CHD3
CNTN4
COL1A1
COMMD1
CSTF1
DCAF8L2
DCC
DDX39B
DNAI7
ELP1
ESR1
EWSR1
EXOC5
FAM9B
FEZ1
FKBP1A
FKBP2
FKBP3
FUCA1
GIT1
GOLGA2
GPRASP2
H2AC20
H2AC4
H2BC3
H3C1
HAP1
HNRNPC
HNRNPLL
HSF2BP
HSPA14
IDI1
IKZF1
ING5
KAT5
KAT7
KBTBD7
KIFC3
KRT40
LARP7
LDOC1
LGALS8
LRIF1
MACROH2A1
MAGED1
MDC1
MRPS22
MSH2
MSH3
MSH6
MT-ND1
MT2A
MTUS2
NFKB1
NFKBIA
NPC2
PCBP2
PDXK
PDZD8
PIAS1
PIAS4
PIN1
POLR2A
POLR2H
POMZP3
POU2F1
PSMA7
PTN
RABEP1
RAD51
RBBP8
RBMY2BP
RNF10
RPS20
SELENBP1
SETDB1
SKIC8
SMCHD1
SNRNP200
SNX3
SPAG5
SRSF2
TCERG1
TERF2
TMEM248
TOP1
TP53
TRAF1
TRAPPC11
TRAPPC8
TULP2
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2K
UBE2N
UBE2U
UBE2W
UBE3A
UBR5
UBXN1
WRN
XRCC6
ZFP64
ZHX1
ZNF121
ZNF655
Entrez ID
672
580
HPRD ID
00218
03354
Ensembl ID
ENSG00000012048
ENSG00000138376
Uniprot IDs
A0A0U1RRA9
A0A2R8Y7V5
A0A9Y1QPR4
A0A9Y1QPT7
A0A9Y1QPY6
A0A9Y1QQ47
A0A9Y1QQD3
A0A9Y1QQF1
A0A9Y1QQJ6
A0A9Y1QQK3
A0A9Y1QQK7
A0A9Y1VR53
A0A9Y1VVD0
A0A9Y1VVE2
B4DES0
C9IZW4
E7ENB7
E7EQW4
E7EUM2
H0Y850
H0Y8D8
P38398
A0A087WZ19
A0AVN2
C9IYG1
F6MDI0
F6MDI1
F6MDI2
Q99728
PDB IDs
1JM7
1JNX
1N5O
1OQA
1T15
1T29
1T2U
1T2V
1Y98
2ING
3COJ
3K0H
3K0K
3K15
3K16
3PXA
3PXB
3PXC
3PXD
3PXE
4IFI
4IGK
4JLU
4OFB
4U4A
4Y18
4Y2G
6G2I
7JZV
7LYB
8GRQ
1JM7
2NTE
2R1Z
3C5R
3FA2
6M14
7E8I
7JZV
7LYB
7LYC
8GRQ
Enriched GO Terms of Interacting Partners
?
Nucleoplasm
Nucleus
DNA Damage Response
Nucleic Acid Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Metabolic Process
Cellular Response To Stress
Regulation Of Macromolecule Metabolic Process
Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
DNA Repair
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Negative Regulation Of Metabolic Process
Double-strand Break Repair
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA Metabolic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Cell Cycle Phase Transition
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cell Cycle
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Biosynthetic Process
Chromatin Binding
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Cell Cycle Phase Transition
Response To Ionizing Radiation
Response To Radiation
Positive Regulation Of Transcription By RNA Polymerase II
DNA Damage Checkpoint Signaling
Signal Transduction In Response To DNA Damage
Positive Regulation Of DNA Metabolic Process
Enzyme Binding
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Cellular Response To Stress
Chromatin Organization
Chromosome, Telomeric Region
DNA Damage Response
Nucleoplasm
DNA Repair
Ubiquitin Conjugating Enzyme Activity
DNA Metabolic Process
Chromosome
Nucleus
Chromatin Organization
Nucleic Acid Metabolic Process
Chromosome, Telomeric Region
Regulation Of DNA Metabolic Process
Chromatin Remodeling
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Metabolic Process
Cellular Response To Stress
Negative Regulation Of Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Nucleobase-containing Compound Metabolic Process
Epigenetic Regulation Of Gene Expression
Protein Polyubiquitination
Protein K48-linked Ubiquitination
Double-strand Break Repair
Regulation Of Primary Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Chromosome Organization
Enzyme Binding
Modification-dependent Protein Catabolic Process
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of DNA Metabolic Process
Ubiquitin Protein Ligase Binding
Post-translational Protein Modification
Maintenance Of DNA Repeat Elements
Heterochromatin Formation
Negative Regulation Of DNA Recombination
Chromatin Binding
Protein Monoubiquitination
Regulation Of Gene Expression
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of DNA Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Macromolecule Metabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Single Guanine Insertion Binding
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Ubiquitin-protein Transferase Activity
Negative Regulation Of Gene Expression, Epigenetic
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Tagcloud (Difference)
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Tagcloud (Intersection)
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