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BRCA1 and AKT1
Number of citations of the paper that reports this interaction (PubMedID
20085797
)
69
Data Source:
BioGRID
(imaging technique)
HPRD
(in vitro, in vivo)
BRCA1
AKT1
Description
BRCA1 DNA repair associated
AKT serine/threonine kinase 1
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nuclear Ubiquitin Ligase Complex
Condensed Chromosome
Condensed Nuclear Chromosome
Lateral Element
Gamma-tubulin Ring Complex
Male Germ Cell Nucleus
XY Body
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Plasma Membrane
Nuclear Body
BRCA1-BARD1 Complex
Protein-containing Complex
BRCA1-A Complex
BRCA1-B Complex
BRCA1-C Complex
DNA Repair Complex
Ribonucleoprotein Complex
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Intermembrane Space
Endoplasmic Reticulum
Spindle
Cytosol
Plasma Membrane
Cell-cell Junction
Cilium
Cell Cortex
Microtubule Cytoskeleton
Membrane
Lamellipodium
Vesicle
Protein-containing Complex
Ciliary Basal Body
Postsynapse
Glutamatergic Synapse
Molecular Function
Transcription Cis-regulatory Region Binding
P53 Binding
DNA Binding
Damaged DNA Binding
Transcription Coactivator Activity
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Tubulin Binding
Transferase Activity
Enzyme Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Ubiquitin-modified Histone Reader Activity
RNA Polymerase Binding
Histone H2AK127 Ubiquitin Ligase Activity
Histone H2AK129 Ubiquitin Ligase Activity
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
Calmodulin Binding
ATP Binding
Phosphatidylinositol-3,4,5-trisphosphate Binding
Kinase Activity
Transferase Activity
Enzyme Binding
Kinase Binding
Protein Kinase Binding
Nitric-oxide Synthase Regulator Activity
Protein Serine/threonine Kinase Inhibitor Activity
Identical Protein Binding
Protein Homodimerization Activity
Phosphatidylinositol-3,4-bisphosphate Binding
14-3-3 Protein Binding
Potassium Channel Activator Activity
Protein Serine Kinase Activity
TORC2 Complex Binding
Biological Process
Double-strand Break Repair Via Homologous Recombination
DNA Repair
Regulation Of DNA Repair
Postreplication Repair
Double-strand Break Repair
DNA Recombination
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Lipid Metabolic Process
Fatty Acid Metabolic Process
Fatty Acid Biosynthetic Process
DNA Damage Response
Chromosome Segregation
Mitotic G2 DNA Damage Checkpoint Signaling
Centrosome Cycle
Sex-chromosome Dosage Compensation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Ionizing Radiation
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Protein Ubiquitination
Negative Regulation Of Cell Growth
Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Homologous Recombination
Chordate Embryonic Development
Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation
Mitotic G2/M Transition Checkpoint
Negative Regulation Of Fatty Acid Biosynthetic Process
Positive Regulation Of DNA Repair
Positive Regulation Of Angiogenesis
Negative Regulation Of Cell Cycle
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Centriole Replication
Regulation Of Cell Cycle
Protein Autoubiquitination
Random Inactivation Of X Chromosome
Cellular Response To Tumor Necrosis Factor
Cellular Response To Ionizing Radiation
Cellular Response To Indole-3-methanol
Protein K6-linked Ubiquitination
DNA Strand Resection Involved In Replication Fork Processing
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of DNA Damage Checkpoint
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Osteoblast Differentiation
Maternal Placenta Development
Positive Regulation Of Endothelial Cell Proliferation
Cell Migration Involved In Sprouting Angiogenesis
Cytoplasmic Translation
Complement Receptor Mediated Signaling Pathway
Sphingosine-1-phosphate Receptor Signaling Pathway
Glycogen Metabolic Process
Glycogen Biosynthetic Process
Regulation Of Glycogen Biosynthetic Process
Glucose Metabolic Process
Gluconeogenesis
Translational Initiation
Regulation Of Translation
Protein Phosphorylation
Ubiquitin-dependent Protein Catabolic Process
Protein Import Into Nucleus
NLS-bearing Protein Import Into Nucleus
Nitric Oxide Biosynthetic Process
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Golgi To Plasma Membrane Transport
Apoptotic Process
Activation-induced Cell Death Of T Cells
Inflammatory Response
Response To Oxidative Stress
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Germ Cell Development
Nervous System Development
Cell Population Proliferation
Insulin Receptor Signaling Pathway
Apoptotic Mitochondrial Changes
Cellular Response To Starvation
Response To Heat
Response To Hormone
Gene Expression
Negative Regulation Of Autophagy
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane
Fibroblast Migration
Positive Regulation Of Fibroblast Migration
Positive Regulation Of Sodium Ion Transport
Positive Regulation Of Glucose Metabolic Process
Regulation Of Neuron Projection Development
Negative Regulation Of Macroautophagy
Phosphorylation
Cell Migration
Protein Ubiquitination
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Cytokine-mediated Signaling Pathway
Mammalian Oogenesis Stage
Cell Differentiation
Protein Catabolic Process
Positive Regulation Of Cell Growth
Regulation Of Cell Migration
Positive Regulation Of Cell Migration
Negative Regulation Of Cell Migration
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
T Cell Costimulation
Negative Regulation Of Protein Ubiquitination
Regulation Of Myelination
Lipopolysaccharide-mediated Signaling Pathway
Cellular Response To Nutrient Levels
TOR Signaling
Negative Regulation Of Fatty Acid Beta-oxidation
Positive Regulation Of Endodeoxyribonuclease Activity
Response To Food
Peripheral Nervous System Myelin Maintenance
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Insulin Stimulus
Regulation Of Protein Localization
Positive Regulation Of Peptidyl-serine Phosphorylation
Cellular Response To Stress
Negative Regulation Of Toll-like Receptor Signaling Pathway
Positive Regulation Of Toll-like Receptor Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Cellular Response To Amino Acid Starvation
Response To Fluid Shear Stress
Protein K29-linked Ubiquitination
Intracellular Signal Transduction
Interleukin-18-mediated Signaling Pathway
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Cellular Response To Decreased Oxygen Levels
SREBP-SCAP Complex Retention In Endoplasmic Reticulum
TRNA Stabilization
Calcium Import Into The Mitochondrion
PERK-mediated Unfolded Protein Response
TORC1 Signaling
Glucose Homeostasis
Regulation Of Apoptotic Process
Golgi To Plasma Membrane Protein Transport
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Anoikis
Regulation Of MRNA Stability
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Cholesterol Biosynthetic Process
Positive Regulation Of Fat Cell Differentiation
Positive Regulation Of Cilium Assembly
Positive Regulation Of Glycogen Biosynthetic Process
Negative Regulation Of Notch Signaling Pathway
Negative Regulation Of Proteolysis
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Translational Initiation
Positive Regulation Of Translational Initiation
Nitric Oxide Metabolic Process
Positive Regulation Of D-glucose Import
Positive Regulation Of Organ Growth
Protein Autophosphorylation
Positive Regulation Of Lipid Biosynthetic Process
Insulin-like Growth Factor Receptor Signaling Pathway
Behavioral Response To Pain
Positive Regulation Of Smooth Muscle Cell Proliferation
Striated Muscle Cell Differentiation
Positive Regulation Of Protein Metabolic Process
Protein Maturation
Excitatory Postsynaptic Potential
Response To Growth Hormone
Regulation Of Vesicle-mediated Transport
Mammary Gland Epithelial Cell Differentiation
Labyrinthine Layer Blood Vessel Development
Protein Localization To Cilium
Response To UV-A
Response To Growth Factor
Protein Localization To Endoplasmic Reticulum
Protein K11-linked Ubiquitination
Cellular Response To Calcium Ion
Cellular Response To Tumor Necrosis Factor
Cellular Response To Growth Factor Stimulus
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Prostaglandin E Stimulus
Tricarboxylic Acid Metabolic Process
Establishment Of Protein Localization To Mitochondrion
Maintenance Of Protein Location In Mitochondrion
Cellular Response To Rapamycin
Protein K6-linked Ubiquitination
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Execution Phase Of Apoptosis
Vascular Endothelial Cell Response To Laminar Fluid Shear Stress
Regulation Of Postsynapse Organization
TRNA (guanine-N7)-methylation
Regulation Of TRNA Methylation
Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus
CGAS/STING Signaling Pathway
Negative Regulation Of Protein Localization To Lysosome
Negative Regulation Of CGAS/STING Signaling Pathway
Beta-arrestin-dependent Dopamine Receptor Signaling Pathway
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Protein Localization To Nucleus
Cellular Response To Peptide
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Cilium Assembly
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Protein Localization To Plasma Membrane
Negative Regulation Of Protein Maturation
Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of PERK-mediated Unfolded Protein Response
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Positive Regulation Of TORC2 Signaling
Positive Regulation Of Protein Localization To Endoplasmic Reticulum
Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
Cellular Response To Nerve Growth Factor Stimulus
Response To Insulin-like Growth Factor Stimulus
Positive Regulation Of Protein Localization To Cell Surface
Regulation Of Type B Pancreatic Cell Development
Negative Regulation Of Lymphocyte Migration
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Meiotic synapsis
SUMOylation of DNA damage response and repair proteins
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Metalloprotease DUBs
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
TP53 Regulates Transcription of DNA Repair Genes
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Neddylation
Transcriptional Regulation by E2F6
Meiotic recombination
Defective DNA double strand break response due to BRCA1 loss of function
Defective DNA double strand break response due to BARD1 loss of function
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Impaired BRCA2 binding to RAD51
Impaired BRCA2 binding to PALB2
KEAP1-NFE2L2 pathway
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence
Activation of BAD and translocation to mitochondria
PIP3 activates AKT signaling
PIP3 activates AKT signaling
Downregulation of ERBB2:ERBB3 signaling
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
MTOR signalling
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
eNOS activation
AKT-mediated inactivation of FOXO1A
Integrin signaling
Deactivation of the beta-catenin transactivating complex
CD28 dependent PI3K/Akt signaling
Co-inhibition by CTLA4
G beta:gamma signalling through PI3Kgamma
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in Cancer
Interleukin-4 and Interleukin-13 signaling
Regulation of TP53 Degradation
Regulation of TP53 Activity through Acetylation
Regulation of TP53 Activity through Association with Co-factors
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Cyclin E associated events during G1/S transition
Cyclin A:Cdk2-associated events at S phase entry
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
RAB GEFs exchange GTP for GDP on RABs
RUNX2 regulates genes involved in cell migration
Regulation of PTEN stability and activity
Extra-nuclear estrogen signaling
Negative regulation of NOTCH4 signaling
FLT3 Signaling
Regulation of localization of FOXO transcription factors
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
KEAP1-NFE2L2 pathway
SARS-CoV-2 targets host intracellular signalling and regulatory pathways
Mitochondrial unfolded protein response (UPRmt)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Drugs
ATP
Arsenic trioxide
Genistein
Inositol 1,3,4,5-Tetrakisphosphate
Resveratrol
Archexin
Enzastaurin
Perifosine
N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
Diseases
Ovarian cancer
Breast cancer
PTEN hamartoma tumor syndrome (PHTS), including: Cowden syndrome; Bannayan-Riley-Ruvalcaba syndrome; Proteus syndrome; Proteus-like syndrome
GWAS
Aspartate aminotransferase levels (
33547301
)
Gynecologic disease (multivariate analysis) (
31488892
)
Menopause (age at onset) (
26414677
29773799
)
Monocyte percentage of white cells (
32888494
)
Ovarian cancer (
31488892
)
Ovarian cancer (MTAG) (
31488892
)
Apolipoprotein A1 levels (
32203549
)
Endometrial cancer (
27135401
)
Endometrial endometrioid carcinoma (
27135401
)
HDL cholesterol (
24097068
25961943
30275531
)
HDL cholesterol levels (
28334899
32203549
)
Neutrophil count (
32888494
)
Vitamin C levels (
33203707
)
Interacting Genes
323 interacting genes:
ABL1
ABRAXAS1
ACACA
ACTG1
ACTN3
AKT1
ALDH1A1
ANKRD28
ANTXR1
AP1M1
APLP2
AR
ARNT
ASH2L
ATF1
ATM
ATP1B1
ATP1B3
ATR
ATRIP
AURKA
AURKC
BABAM1
BAP1
BARD1
BRAP
BRAT1
BRCA2
BRCC3
BRIP1
BRSK1
CABYR
CASP3
CATSPERT
CAVIN3
CBX1
CBX5
CCDC120
CCNA1
CCNA2
CCNB1
CCND1
CDC25C
CDK1
CDK2
CDK4
CDK7
CDKN2D
CEP57L1
CHEK1
CHEK2
CLSPN
CNRIP1
CNTLN
CNTN4
COL1A1
COMMD1
CREBBP
CRY2
CRYZL1
CSNK1D
CSNK2A1
CSNK2B
CSTF1
CTBP1
CTCFL
CTNNB1
CUBN
CWF19L2
DALRD3
DBF4
DCLRE1C
DCN
DDX24
DES
DHPS
DHX9
DNAJA1
DNAJA3
DNAJB1
DNHD1
DYNC1H1
DYNLT2B
E2F1
E2F4
EED
EIF3B
EIF4A2
EIF5B
ELK1
ELK4
ELOA
ENO1
EP300
ERCC5
ERO1B
ESR1
ETS1
ETV5
EZH2
FAM161A
FAM184A
FANCA
FANCD2
FBXO44
FHL2
FLI1
FLNA
FXR2
GCC1
GFI1B
GGN
GOLGA8DP
GTF3C4
GUSBP1
H2AC20
H2AC4
H2AX
H2BC3
H3C1
HDAC1
HDAC2
HECTD3
HGF
HIBADH
HIVEP1
HNRNPC
HNRNPD
HORMAD1
HSPA14
HSPA8
HSPD1
IFI16
INPP1
ITIH5
ITPR1
ITPRID2
JAK1
JAK2
JUN
JUNB
JUND
JUP
KAT5
KDM1A
KIF1B
KPNA2
KPNA6
LARP7
LCK
LCMT1
LDHC
LMNTD1
LMO4
LONRF1
MACROH2A1
MAN2C1
MAP3K1
MAP3K14
MAP3K3
MAP4K4
MARCKSL1
MDC1
MED1
MED21
MID2
MLH1
MNAT1
MSH2
MSH3
MSH6
MT-ND1
MYC
MYOZ1
NBN
NCOA2
NCOA3
NELFB
NFKB1
NFYA
NKAPL
NMI
NPC2
NRIP1
NSD2
NUFIP1
NUP153
OBSCN
PARG
PEG3
PEX5
PGR
PHF12
PIAS1
PIAS4
PIK3R1
PILRB
PIN1
PISD
POLB
POLR2A
POLR2H
POLR2K
POM121
POMGNT1
POU2F1
PPP1CA
PPP1CB
PPP1R13B
PPP2R5C
PREP
PRKAG3
PRKDC
PRMT1
PRPF3
PSAP
PSMA6
PSMA7
PSMD9
PSMG1
RACK1
RAD51
RANBP9
RB1
RBBP4
RBBP7
RBBP8
RBL1
RBL2
RCC1L
RELA
RFC1
RNF216
RPGRIP1
RPL31
RTKN2
RTL10
RUNX1T1
RWDD2B
RWDD4
SDK2
SETX
SKP2
SMAD2
SMAD3
SMAD4
SMARCA2
SMARCA4
SMC1A
SNRNP200
SNX3
SNX6
SOX30
SP1
SPATA4
SQSTM1
SSX2IP
STAC2
STAT1
STAT3
STAT5A
SUMO1
SYT6
TARS1
TATDN2
TCEA2
TCEANC
TEX101
THOC3
TLE4
TMPRSS12
TNS2
TOP1
TOP2A
TOP2B
TP53
TP53BP1
TPTE2
TRIM24
TRIM46
TRIM47
TRIM74
TRRAP
TSEN54
TSGA10IP
TUBA4A
TUBB
TUBG1
TULP2
TXLNA
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2J1
UBE2K
UBE2L3
UBE2N
UBE2T
UBE2W
UBE3A
UBXN1
USF2
USH2A
USP2
VCP
VHL
WDR6
WNT2B
WRN
XAF1
XIAP
XRCC1
XRCC5
YY1
ZNF280D
ZNF350
ZNF423
ZSCAN21
396 interacting genes:
ABI1
ABRAXAS1
ACAP1
ACAT2
AGAP2
AGR3
AHNAK
AHSA1
AKT1S1
AKT2
AKTIP
ALYREF
AMBRA1
APLP2
APOE
APOH
APP
APPL1
AR
ARAF
ARFIP2
ARHGAP9
ARHGEF16
ARHGEF28
ARNT
ATXN1
AURKA
BABAM1
BAD
BAG6
BCL10
BCL2L1
BCL2L11
BCL3
BECN1
BEX1
BLVRA
BPGM
BRAF
BRCA1
BTRC
BUB1
C1orf174
CAMKK1
CARHSP1
CASC3
CASP3
CASP9
CASTOR1
CBLC
CCDC88A
CCND2
CCNE1
CCNF
CCNI
CCT2
CD44
CDC37
CDH1
CDK1
CDK4
CDK6
CDKN1A
CDKN1B
CDKN1C
CDKN2A
CDKN2B
CDKN2C
CEP57L1
CEP76
CGGBP1
CHEK1
CHUK
CLASP2
CLIP3
CLK2
CMTM8
CNKSR3
CNOT9
CREB1
CREBBP
CSNK2A1
CTDP1
CTDSP2
CTNNA1
CTNNB1
CYLD
DAB2IP
DCTN1
DDIT4L
DLC1
DNAJB1
DNMT1
EEF1G
EFHC1
EIF4EBP1
ELAVL1
EMSY
ENO2
EP300
EPHA2
EPSTI1
ERBB2
ESR1
ESR2
EZH2
FAF1
FAM168A
FANCA
FANCI
FASN
FBXO31
FBXW7
FGFR4
FOXO1
FOXO3
FOXO4
FUS
FXN
GAB1
GAB2
GATA1
GATA2
GET4
GFAP
GJA1
GLIS2
GMPPA
GPT2
GRB10
GRIN2A
GSK3A
GSK3B
H2BC21
H2BC3
HEATR3
HIF1A
HMOX1
HSP90AA1
HSP90AB1
HSPB1
HTT
IKBKB
IL13RA2
IL24
ILK
IMPDH2
IRAK1
IRS1
ISCA2
ITCH
ITGB3
ITPKB
ITPR1
ITPR3
IWS1
JADE1
KANK1
KAT2A
KAT2B
KAT6A
KDELR2
KLHL3
KLRC1
KMT2D
KRT10
LANCL2
LATS2
LRRK2
LTB4R2
MAGEB1
MAP2K3
MAP2K4
MAP2K5
MAP2K6
MAP3K11
MAP3K5
MAP3K8
MAPK4
MAPK8
MAPK8IP1
MAPK9
MAPKAP1
MAPKAPK2
MAPT
MARK4
MATK
MDM2
MDM4
MEF2D
MESD
METTL1
MLF2
MLH3
MOK
MRC2
MS4A2
MSH2
MST1R
MTA3
MTCP1
MTOR
MTUS2
MUL1
MXD1
MYC
NCF2
NCKIPSD
NCOA4
NCOR2
NEDD4
NEDD4L
NF1
NF2
NGB
NHERF1
NIBAN1
NKD1
NLGN3
NOL4
NOS3
NOTCH1
NR4A1
NRAS
NRIP2
NSD3
OFD1
OSBPL11
OSGIN1
OTUD1
OXSR1
PAK1
PCGF2
PCK1
PDE3A
PDE3B
PDGFRA
PDHB
PDK1
PDK2
PDPK1
PEA15
PFKFB1
PFKFB2
PFKP
PHB2
PI4K2B
PIAS1
PIAS2
PICK1
PIK3CA
PIK3R1
PIP5K1C
PKN2
PLCG1
PLEKHO1
PLP1
PLXNA1
PMS2
POP4
POP7
PPARGC1B
PPL
PPM1A
PPM1H
PPP1CA
PPP1R11
PPP2CA
PPP2R1A
PRG2
PRKAR1A
PRKCQ
PRKCZ
PRKDC
PSMC5
PSRC1
PTEN
PTGDS
PTPA
PTPN1
PTPN11
PTPN3
PYCR3
PYGO2
RAB3D
RAC1
RAF1
RAP1GDS1
RARA
RASL10B
RASSF1
REPS1
REX1BD
RGCC
RHEBL1
RNF11
RNF115
RPS6KB1
RUVBL2
S100A14
S1PR1
SERPINB5
SETDB1
SFMBT2
SH2B2
SH3RF1
SHANK2
SHQ1
SIRPA
SIRT1
SIRT6
SKI
SKP2
SLFN5
SMAD2
SMAD3
SMAD4
SMAD7
SMARCB1
SMARCC1
SNCA
SNCB
SORBS1
SORBS2
SOX4
SP1
SP3
SPACA6
SPATA33
SRC
SRPK2
SRR
SSH1
ST14
STAT1
STK11
STK3
STK4
STOX1
SULT4A1
SUPT6H
SYTL1
TBC1D4
TBC1D7
TBCE
TCL1A
TCL1B
TCL6
TEAD2
TERF2IP
TERT
TFF1
THEM4
THRSP
TLR2
TMCC2
TNFRSF1A
TNFSF11
TNK2
TOPBP1
TP53
TRAF6
TRIB3
TRIM13
TRIM24
TRIT1
TRMT2B
TSC1
TSC2
TTC3
UBE2S
UCHL1
UHRF1
URI1
USP10
USP4
USP50
UXS1
VEGFA
VHL
VIM
WDR53
WEE1
WNK1
WNK4
XAF1
XIAP
YAP1
YBX1
YIF1B
YWHAZ
ZC3HAV1
ZFP36L1
ZHX1
ZNF691
ZRANB1
Entrez ID
672
207
HPRD ID
00218
01261
Ensembl ID
ENSG00000012048
ENSG00000142208
Uniprot IDs
A0A0U1RRA9
A0A2R8Y7V5
A0A9Y1QPR4
A0A9Y1QPT7
A0A9Y1QPY6
A0A9Y1QQ47
A0A9Y1QQD3
A0A9Y1QQF1
A0A9Y1QQJ6
A0A9Y1QQK3
A0A9Y1QQK7
A0A9Y1VR53
A0A9Y1VVD0
A0A9Y1VVE2
B4DES0
C9IZW4
E7ENB7
E7EQW4
E7EUM2
H0Y850
H0Y8D8
P38398
B0LPE5
B3KVH4
P31749
PDB IDs
1JM7
1JNX
1N5O
1OQA
1T15
1T29
1T2U
1T2V
1Y98
2ING
3COJ
3K0H
3K0K
3K15
3K16
3PXA
3PXB
3PXC
3PXD
3PXE
4IFI
4IGK
4JLU
4OFB
4U4A
4Y18
4Y2G
6G2I
7JZV
7LYB
8GRQ
1H10
1UNP
1UNQ
1UNR
2UVM
2UZR
2UZS
3CQU
3CQW
3MV5
3MVH
3O96
3OCB
3OW4
3QKK
3QKL
3QKM
4EJN
4EKK
4EKL
4GV1
5KCV
6BUU
6CCY
6HHF
6HHG
6HHH
6HHI
6HHJ
6NPZ
6S9W
6S9X
7APJ
7MYX
7NH4
7NH5
8JOW
8UVY
8UW2
8UW7
8UW9
8ZPU
Enriched GO Terms of Interacting Partners
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Nucleoplasm
Nucleus
DNA Damage Response
Nucleic Acid Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Metabolic Process
Cellular Response To Stress
Regulation Of Macromolecule Metabolic Process
Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
DNA Repair
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Negative Regulation Of Metabolic Process
Double-strand Break Repair
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA Metabolic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Cell Cycle Phase Transition
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cell Cycle
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Biosynthetic Process
Chromatin Binding
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Cell Cycle Phase Transition
Response To Ionizing Radiation
Response To Radiation
Positive Regulation Of Transcription By RNA Polymerase II
DNA Damage Checkpoint Signaling
Signal Transduction In Response To DNA Damage
Positive Regulation Of DNA Metabolic Process
Enzyme Binding
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Cellular Response To Stress
Chromatin Organization
Chromosome, Telomeric Region
Intracellular Signal Transduction
Regulation Of Signal Transduction
Cytosol
Regulation Of Signaling
Regulation Of Programmed Cell Death
Regulation Of Cell Communication
Regulation Of Intracellular Signal Transduction
Regulation Of Apoptotic Process
Cytoplasm
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Signal Transduction
Negative Regulation Of Signal Transduction
Positive Regulation Of Signal Transduction
Cellular Response To Stress
Regulation Of Cell Population Proliferation
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Regulation Of Primary Metabolic Process
Intracellular Signaling Cassette
Regulation Of Metabolic Process
Regulation Of Protein Metabolic Process
Negative Regulation Of Intracellular Signal Transduction
Regulation Of Macromolecule Metabolic Process
Response To Stress
Regulation Of Developmental Process
Positive Regulation Of Protein Metabolic Process
Nucleus
Nucleoplasm
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Metabolic Process
Negative Regulation Of Apoptotic Process
Kinase Activity
Cellular Response To Oxygen-containing Compound
Regulation Of Cell Cycle
Protein Kinase Activity
Regulation Of Protein Stability
Cell Surface Receptor Signaling Pathway
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Multicellular Organismal Process
Protein Modification Process
Regulation Of Phosphorus Metabolic Process
MAPK Cascade
Protein Serine Kinase Activity
Protein Kinase Binding
Regulation Of Protein Modification Process
Regulation Of Apoptotic Signaling Pathway
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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