BRCA1 and NFKB1

Number of citations of the paper that reports this interaction (PMID 12700228)
12

Data Source:
HPRD (in vitro, in vivo)

		BRCA1	NFKB1
Gene Name		breast cancer 1, early onset	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Cytoplasm Plasma Membrane Gamma-tubulin Ring Complex Ribonucleoprotein Complex BRCA1-BARD1 Complex Protein Complex BRCA1-A Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol I-kappaB/NF-kappaB Complex
	Molecular Function	DNA Binding Damaged DNA Binding Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Tubulin Binding Ligase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Transcription Regulatory Region DNA Binding Androgen Receptor Binding	Regulatory Region DNA Binding Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Heat Shock Protein Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Postreplication Repair Double-strand Break Repair Regulation Of Gene Expression By Genetic Imprinting Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase III Promoter Fatty Acid Biosynthetic Process Apoptotic Process Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Chromosome Segregation Centrosome Cycle Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Dosage Compensation By Inactivation Of X Chromosome Response To Ionizing Radiation Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Protein Ubiquitination Androgen Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination G2 DNA Damage Checkpoint Positive Regulation Of Histone Acetylation Negative Regulation Of Histone Acetylation Regulation Of Cell Proliferation Regulation Of Apoptotic Process Chordate Embryonic Development Response To Estrogen Regulation Of DNA Methylation Negative Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of DNA Repair Positive Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Centriole Replication Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Protein Autoubiquitination Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Cell Cycle Arrest Cellular Response To Tumor Necrosis Factor Cellular Response To Indole-3-methanol Protein K6-linked Ubiquitination Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Histone H4-K16 Acetylation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Apoptotic Process Inflammatory Response Response To Oxidative Stress I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Negative Regulation Of Calcidiol 1-monooxygenase Activity Negative Regulation Of Vitamin D Biosynthetic Process Membrane Protein Intracellular Domain Proteolysis Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cholesterol Transport Positive Regulation Of Type I Interferon Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Interleukin-12 Biosynthetic Process Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Copper Ion Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Inflammatory Response T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Nicotine Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of MiRNA Metabolic Process
Pathways		ATM mediated phosphorylation of repair proteins Meiotic recombination Fanconi Anemia pathway ATM mediated response to DNA double-strand break Homologous Recombination Repair Meiotic synapsis Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Double-Strand Break Repair	Signaling by the B Cell Receptor (BCR) NF-kB is activated and signals survival Downstream TCR signaling Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Downstream signaling events of B Cell Receptor (BCR) FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs p75NTR signals via NF-kB Transcriptional regulation of white adipocyte differentiation MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Regulated proteolysis of p75NTR Signalling by NGF TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Senescence-Associated Secretory Phenotype (SASP) Cytokine Signaling in Immune system p75 NTR receptor-mediated signalling MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Signaling by Interleukins TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Interleukin-1 processing Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Activation of NF-kappaB in B cells Fc epsilon receptor (FCERI) signaling TRAF6 mediated NF-kB activation Interleukin-1 signaling Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs			Thalidomide Pranlukast Triflusal
Diseases
GWAS			Multiple sclerosis ( 21833088) Primary biliary cirrhosis ( 23000144 21399635) Schizophrenia (treatment refractory) ( 22479419) Ulcerative colitis ( 23128233)
Protein-Protein Interactions		312 interactors: ABL1 ABLIM3 ACACA ACTG1 ACTN3 AHR AKT1 ALDH1A1 ALS2CR11 ANTXR1 AP1M1 APLP2 AR ARNT ASH2L ATF1 ATM ATP1B1 ATP1B3 ATR ATRIP AURKA AURKC BABAM1 BAP1 BARD1 BRAP BRAT1 BRCA2 BRCC3 BRIP1 BRSK1 C22orf29 CABYR CASP3 CCDC120 CCNA1 CCNA2 CCNB1 CCND1 CDK1 CDK16 CDK2 CDK4 CDK5 CDK7 CDK9 CDKN2D CEP57L1 CHEK1 CHEK2 CLSPN CNRIP1 CNTLN CNTN4 COL1A1 COMMD1 CREBBP CRIPAK CRY2 CRYZL1 CSNK1D CSNK2A1 CSNK2B CSTF1 CTBP1 CTCFL CTNNB1 CUBN CWF19L2 DALRD3 DBF4 DCLRE1C DCN DDX24 DES DHPS DHX9 DNAJA1 DNAJA3 DNAJB1 DNHD1 DYNC1H1 E2F1 E2F4 EED EIF3B EIF4A2 EIF5B ELK1 ELK4 ENO1 EP300 ERCC6 ERO1LB ESR1 ETS1 ETV5 EZH2 FAM161A FAM175A FAM184A FANCA FANCD2 FHL2 FLI1 FXR2 GCC1 GFI1B GGN GOLGA8DP GTF3C4 GUSBP1 H2AFX H2AFY HDAC1 HDAC2 HECTD3 HERC2 HGF HIBADH HIST1H2AB HIST2H2AC HIVEP1 HNRNPC HNRNPD HORMAD1 HSPA14 HSPA8 HSPD1 IFI16 INPP1 ITIH5 JAK1 JAK2 JUN JUNB JUND JUP KAT2A KAT5 KDM1A KIF1B KPNA2 KPNA6 LCK LCMT1 LDHC LMNTD1 LMO4 LONRF1 MAN2C1 MAP3K1 MAP3K14 MAP3K3 MAP4K4 MARCKSL1 MDC1 MED1 MED21 MID2 MLH1 MNAT1 MRE11A MSH2 MSH3 MSH6 MYC MYOZ1 NBN NCOA2 NCOA3 ND1 NELFB NFKB1 NFYA NKAPL NMI NPC2 NRIP1 NUFIP1 NUP153 OBSCN OLA1 PEG3 PEX5 PGR PHF12 PIAS1 PIAS4 PIK3R1 PILRB PISD POLR2A POLR2H POLR2K POM121 POMGNT1 POU2F1 PPHLN1 PPP1CA PPP1CB PPP1R13B PPP2R5C PREP PRKAG3 PRKDC PRMT1 PRPF3 PSAP PSMA6 PSMD9 PSMG1 RAD51 RANBP9 RB1 RBBP4 RBBP7 RBBP8 RBL1 RBL2 RBX1 RELA RFC1 RNF216 RPGRIP1 RPL31 RTKN2 RUNX1T1 RWDD2B RWDD4 SDK2 SETX SHFM1 SMAD2 SMAD3 SMAD4 SMARCA2 SMARCA4 SMC1A SNRNP200 SNX3 SNX6 SOX30 SP1 SPATA4 SRC SSFA2 SSX2IP STAC2 STAT1 STAT3 STAT5A SUMO1 SYT6 TARS TATDN2 TCEA2 TCEANC TCEB3 TCTEX1D2 TEX101 THOC3 TLE4 TMPRSS12 TNS2 TOP2A TP53 TP53BP1 TPTE2 TRIM24 TRIM46 TRIM74 TRRAP TSEN54 TSGA10IP TUBA4A TUBB TUBG1 TULP2 TXLNA UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2J1 UBE2K UBE2L3 UBE2N UBE2T UBE2W UBE3A UBXN1 USF2 USH2A USP2 VCP WBSCR16 WDR6 WNT2B XIAP XRCC1 XRCC5 YY1 ZNF280D ZNF350 ZNF423 ZSCAN21	102 interactors: ABCC2 AR ATF3 BCL3 BRCA1 BTRC CDK9 CEBPB CFLAR CHUK COPB2 COPS5 CTNNB1 E2F1 ECSIT ELF1 ELF3 EP300 ESR1 ETS1 FBXW11 FOS G3BP2 GLUL GSK3B HDAC1 HIF1AN HMGA1 HMGA2 HMGB1 HSPA4 IKBKB IKBKG IL2RA IRF1 IRF2 IRF8 IRF9 ITGB3BP KAT5 KLF5 KPNA3 LYL1 MAP3K8 MEN1 MPP6 MTPN NCOA1 NCOA6 NCOR2 NFKB2 NFKBIA NFKBIB NFKBIE NFKBIZ NFRKB NKRF NOTCH1 NR3C1 NR4A1 PARP1 PCBD1 PDCD11 PELP1 PLD3 PML PPARG PPP4C PRKACA PSMD10 REL RELA RELB RGS14 RIPK1 RPS3 RSF1 RXRA SERPINA3 SF1 SIN3A SP1 SPAG9 SPI1 SPPL2A SRF STAT3 STAT6 TAB2 TNFSF11 TNIP1 TNIP2 TP53BP1 TRIP4 TSC22D3 TXN UBE2D3 UBE2K UNC5CL YWHAQ YY1 ZBTB9
Entrez ID		672	4790
HPRD ID		00218	01238
Ensembl ID		ENSG00000012048	ENSG00000109320
Uniprot IDs		E9PFC7 E9PFZ0 P38398 Q1RMC1	P19838
PDB IDs		1JM7 1JNX 1N5O 1OQA 1T15 1T29 1T2U 1T2V 1Y98 2ING 3COJ 3K0H 3K0K 3K15 3K16 3PXA 3PXB 3PXC 3PXD 3PXE	1MDI 1MDJ 1MDK 1NFI 1SVC 2DBF 2O61 3GUT
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Stress Positive Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Cellular Response To DNA Damage Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Cell Cycle Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Repair Cell Cycle Process Regulation Of Cell Cycle Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Response To Abiotic Stimulus Transcription, DNA-templated Gene Expression Regulation Of Gene Expression DNA Metabolic Process Transcription From RNA Polymerase II Promoter RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Response To Stress Cell Cycle Checkpoint Negative Regulation Of Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Chromosome Organization Negative Regulation Of Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Mitotic Cell Cycle Cellular Response To Stimulus DNA Damage Checkpoint Negative Regulation Of RNA Biosynthetic Process Biosynthetic Process Organelle Organization Response To Stimulus	Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Response To Stress Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Response To Organic Substance Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Cellular Response To Organic Substance Response To Stimulus Nucleobase-containing Compound Metabolic Process Cellular Response To Stimulus Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Intracellular Receptor Signaling Pathway Heterocycle Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Cellular Response To Stress Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Defense Response Negative Regulation Of Transcription From RNA Polymerase II Promoter Immune System Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cellular Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Signal Transduction Cell Communication
Tagcloud ?		1b 53bp1 activators associates binds brct cbp cip1 domain emphasized hat homology inherited link manners maps ovarian p100 p110 p21waf1 p53 promoters splice stimulate stimulates suppression transactivation	30min ancestry asks asleep habitual ifng ifngr1 il10 il13 il17a il1b il1r2 il2 il4 il6 il8 interleukins nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender
Tagcloud (Difference) ?		1b 53bp1 activators associates binds brct cbp cip1 domain emphasized hat homology inherited link manners maps ovarian p100 p110 p21waf1 p53 promoters splice stimulate stimulates suppression transactivation	30min ancestry asks asleep habitual ifng ifngr1 il10 il13 il17a il1b il1r2 il2 il4 il6 il8 interleukins nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender
Tagcloud (Intersection) ?