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BRCA1 and MID2
Number of citations of the paper that reports this interaction (PubMedID
25184681
)
73
Data Source:
BioGRID
(two hybrid)
BRCA1
MID2
Description
BRCA1 DNA repair associated
midline 2
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nuclear Ubiquitin Ligase Complex
Condensed Chromosome
Condensed Nuclear Chromosome
Lateral Element
Gamma-tubulin Ring Complex
Male Germ Cell Nucleus
XY Body
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Plasma Membrane
Nuclear Body
BRCA1-BARD1 Complex
Protein-containing Complex
BRCA1-A Complex
BRCA1-B Complex
BRCA1-C Complex
DNA Repair Complex
Ribonucleoprotein Complex
Cytoplasm
Cytoskeleton
Microtubule
Extracellular Exosome
Molecular Function
Transcription Cis-regulatory Region Binding
P53 Binding
DNA Binding
Damaged DNA Binding
Transcription Coactivator Activity
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Tubulin Binding
Transferase Activity
Enzyme Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Ubiquitin-modified Histone Reader Activity
RNA Polymerase Binding
Histone H2AK127 Ubiquitin Ligase Activity
Histone H2AK129 Ubiquitin Ligase Activity
Transcription Coactivator Activity
Protein Binding
Microtubule Binding
Zinc Ion Binding
Transferase Activity
Enzyme Binding
Identical Protein Binding
Protein Homodimerization Activity
Metal Ion Binding
Phosphoprotein Binding
Ubiquitin Protein Ligase Activity
Biological Process
Double-strand Break Repair Via Homologous Recombination
DNA Repair
Regulation Of DNA Repair
Postreplication Repair
Double-strand Break Repair
DNA Recombination
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Lipid Metabolic Process
Fatty Acid Metabolic Process
Fatty Acid Biosynthetic Process
DNA Damage Response
Chromosome Segregation
Mitotic G2 DNA Damage Checkpoint Signaling
Centrosome Cycle
Sex-chromosome Dosage Compensation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Ionizing Radiation
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Protein Ubiquitination
Negative Regulation Of Cell Growth
Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Homologous Recombination
Chordate Embryonic Development
Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation
Mitotic G2/M Transition Checkpoint
Negative Regulation Of Fatty Acid Biosynthetic Process
Positive Regulation Of DNA Repair
Positive Regulation Of Angiogenesis
Negative Regulation Of Cell Cycle
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Centriole Replication
Regulation Of Cell Cycle
Protein Autoubiquitination
Random Inactivation Of X Chromosome
Cellular Response To Tumor Necrosis Factor
Cellular Response To Ionizing Radiation
Cellular Response To Indole-3-methanol
Protein K6-linked Ubiquitination
DNA Strand Resection Involved In Replication Fork Processing
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of DNA Damage Checkpoint
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of Autophagy
Protein Ubiquitination
Negative Regulation Of Viral Transcription
Protein Localization To Microtubule
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Suppression Of Viral Release By Host
Innate Immune Response
Positive Regulation Of DNA-templated Transcription
Host-mediated Suppression Of Symbiont Invasion
Positive Regulation Of Intracellular Signal Transduction
Pathways
Meiotic synapsis
SUMOylation of DNA damage response and repair proteins
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Metalloprotease DUBs
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
TP53 Regulates Transcription of DNA Repair Genes
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Neddylation
Transcriptional Regulation by E2F6
Meiotic recombination
Defective DNA double strand break response due to BRCA1 loss of function
Defective DNA double strand break response due to BARD1 loss of function
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Impaired BRCA2 binding to RAD51
Impaired BRCA2 binding to PALB2
KEAP1-NFE2L2 pathway
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence
Drugs
Diseases
Ovarian cancer
Breast cancer
GWAS
Aspartate aminotransferase levels (
33547301
)
Gynecologic disease (multivariate analysis) (
31488892
)
Menopause (age at onset) (
26414677
29773799
)
Monocyte percentage of white cells (
32888494
)
Ovarian cancer (
31488892
)
Ovarian cancer (MTAG) (
31488892
)
Interacting Genes
323 interacting genes:
ABL1
ABRAXAS1
ACACA
ACTG1
ACTN3
AKT1
ALDH1A1
ANKRD28
ANTXR1
AP1M1
APLP2
AR
ARNT
ASH2L
ATF1
ATM
ATP1B1
ATP1B3
ATR
ATRIP
AURKA
AURKC
BABAM1
BAP1
BARD1
BRAP
BRAT1
BRCA2
BRCC3
BRIP1
BRSK1
CABYR
CASP3
CATSPERT
CAVIN3
CBX1
CBX5
CCDC120
CCNA1
CCNA2
CCNB1
CCND1
CDC25C
CDK1
CDK2
CDK4
CDK7
CDKN2D
CEP57L1
CHEK1
CHEK2
CLSPN
CNRIP1
CNTLN
CNTN4
COL1A1
COMMD1
CREBBP
CRY2
CRYZL1
CSNK1D
CSNK2A1
CSNK2B
CSTF1
CTBP1
CTCFL
CTNNB1
CUBN
CWF19L2
DALRD3
DBF4
DCLRE1C
DCN
DDX24
DES
DHPS
DHX9
DNAJA1
DNAJA3
DNAJB1
DNHD1
DYNC1H1
DYNLT2B
E2F1
E2F4
EED
EIF3B
EIF4A2
EIF5B
ELK1
ELK4
ELOA
ENO1
EP300
ERCC5
ERO1B
ESR1
ETS1
ETV5
EZH2
FAM161A
FAM184A
FANCA
FANCD2
FBXO44
FHL2
FLI1
FLNA
FXR2
GCC1
GFI1B
GGN
GOLGA8DP
GTF3C4
GUSBP1
H2AC20
H2AC4
H2AX
H2BC3
H3C1
HDAC1
HDAC2
HECTD3
HGF
HIBADH
HIVEP1
HNRNPC
HNRNPD
HORMAD1
HSPA14
HSPA8
HSPD1
IFI16
INPP1
ITIH5
ITPR1
ITPRID2
JAK1
JAK2
JUN
JUNB
JUND
JUP
KAT5
KDM1A
KIF1B
KPNA2
KPNA6
LARP7
LCK
LCMT1
LDHC
LMNTD1
LMO4
LONRF1
MACROH2A1
MAN2C1
MAP3K1
MAP3K14
MAP3K3
MAP4K4
MARCKSL1
MDC1
MED1
MED21
MID2
MLH1
MNAT1
MSH2
MSH3
MSH6
MT-ND1
MYC
MYOZ1
NBN
NCOA2
NCOA3
NELFB
NFKB1
NFYA
NKAPL
NMI
NPC2
NRIP1
NSD2
NUFIP1
NUP153
OBSCN
PARG
PEG3
PEX5
PGR
PHF12
PIAS1
PIAS4
PIK3R1
PILRB
PIN1
PISD
POLB
POLR2A
POLR2H
POLR2K
POM121
POMGNT1
POU2F1
PPP1CA
PPP1CB
PPP1R13B
PPP2R5C
PREP
PRKAG3
PRKDC
PRMT1
PRPF3
PSAP
PSMA6
PSMA7
PSMD9
PSMG1
RACK1
RAD51
RANBP9
RB1
RBBP4
RBBP7
RBBP8
RBL1
RBL2
RCC1L
RELA
RFC1
RNF216
RPGRIP1
RPL31
RTKN2
RTL10
RUNX1T1
RWDD2B
RWDD4
SDK2
SETX
SKP2
SMAD2
SMAD3
SMAD4
SMARCA2
SMARCA4
SMC1A
SNRNP200
SNX3
SNX6
SOX30
SP1
SPATA4
SQSTM1
SSX2IP
STAC2
STAT1
STAT3
STAT5A
SUMO1
SYT6
TARS1
TATDN2
TCEA2
TCEANC
TEX101
THOC3
TLE4
TMPRSS12
TNS2
TOP1
TOP2A
TOP2B
TP53
TP53BP1
TPTE2
TRIM24
TRIM46
TRIM47
TRIM74
TRRAP
TSEN54
TSGA10IP
TUBA4A
TUBB
TUBG1
TULP2
TXLNA
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2J1
UBE2K
UBE2L3
UBE2N
UBE2T
UBE2W
UBE3A
UBXN1
USF2
USH2A
USP2
VCP
VHL
WDR6
WNT2B
WRN
XAF1
XIAP
XRCC1
XRCC5
YY1
ZNF280D
ZNF350
ZNF423
ZSCAN21
237 interacting genes:
ADAMTSL4
AEN
ALDH3B1
ANKS1A
AP1M1
AQP1
ARHGEF5
ATOSA
ATOSB
ATRIP
AXIN1
BAHD1
BCL6B
BLK
BLZF1
BRCA1
BRMS1L
BYSL
C1orf35
CALCOCO2
CARD9
CARHSP1
CBX8
CCDC120
CCDC185
CCDC187
CCDC33
CCDC42
CCHCR1
CDK18
CEP57L1
CFP
CHD2
CNNM3
COX5B
CPSF4
CRACR2A
CREBRF
CTSZ
DCX
DGCR6
DGCR6L
DMRT3
DRC4
DYDC1
EFHC2
EGFL7
EIF1AD
ELOA
ENKD1
EPN2
ETNK2
FAM107A
FAM161A
FAM161B
FAM50B
FAM90A1
FARS2
FASTKD5
FBF1
FBXL18
FBXW5
FOXD4L3
FRMD6
FSD2
GAS2L2
GCC1
GEM
GFI1B
GMCL1
GOLGA2
GOLGA7
GORASP2
GPANK1
GPKOW
GSC2
HAPLN2
HCK
HDAC4
HDX
HNRNPLL
HOXB2
HOXB5
HOXB9
IGBP1
IGFN1
IHO1
IKZF3
IL16
INO80B
IQCN
ISCU
ITGB4
JOSD1
KANK2
KIF1A
KIF9
KIFC3
KRT27
KRT31
KRT40
KRT75
KRT76
LAGE3
LENG1
LGALS14
LGALS8
LMNB2
LMNTD2
LMO3
LMO4
LNX1
LONRF1
LRRC45
LZTS1
LZTS2
MAGEA6
MAGOHB
MEOX1
MEOX2
METTL17
MFAP1
MID1
MID1IP1
MOS
MVP
NCOA4
NR1D2
NSMF
NXF1
OTUB2
PICK1
PKN1
POLDIP3
PPP1R18
PRDM16
PRPF3
PRPF31
PSMA1
PTCD2
PTPDC1
QARS1
RABGEF1
RANBP3L
RCOR3
REL
RLN1
RNF6
RORB
RPH3AL
RPP25L
RUNX1T1
RXRB
SCNM1
SDCBP
SEPTIN1
SHFL
SLC25A48
SLC25A6
SNAI1
SNAP47
SPAG5
SPATA24
SPG21
SPRY2
STX11
SYNGAP1
TASOR2
TBC1D22B
TCAF1
TCEA2
TCEANC
TEKT1
THAP7
TMEM14B
TOP3B
TRIM27
TRIM29
TRIM32
TRIM41
TRIM42
TRIM54
TRIM69
TRPV6
TSGA10
TTC23
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E2
UBE2E3
UBE2K
UBE2U
UBTD1
UNC45A
USP2
USP25
USP54
UTP23
UTP25
WT1-AS
ZBTB16
ZBTB24
ZBTB42
ZC2HC1C
ZFYVE21
ZGPAT
ZIM2
ZNF124
ZNF165
ZNF177
ZNF24
ZNF250
ZNF266
ZNF408
ZNF410
ZNF417
ZNF438
ZNF440
ZNF451
ZNF497
ZNF552
ZNF559-ZNF177
ZNF564
ZNF587
ZNF648
ZNF669
ZNF688
ZNF696
ZNF764
ZNF774
ZNF784
ZNF785
ZNF792
ZRANB1
ZSCAN12
Entrez ID
672
11043
HPRD ID
00218
02191
Ensembl ID
ENSG00000012048
ENSG00000080561
Uniprot IDs
A0A0U1RRA9
A0A2R8Y7V5
A0A9Y1QPR4
A0A9Y1QPT7
A0A9Y1QPY6
A0A9Y1QQ47
A0A9Y1QQD3
A0A9Y1QQF1
A0A9Y1QQJ6
A0A9Y1QQK3
A0A9Y1QQK7
A0A9Y1VR53
A0A9Y1VVD0
A0A9Y1VVE2
B4DES0
C9IZW4
E7ENB7
E7EQW4
E7EUM2
H0Y850
H0Y8D8
P38398
Q6GX22
Q9UJV3
PDB IDs
1JM7
1JNX
1N5O
1OQA
1T15
1T29
1T2U
1T2V
1Y98
2ING
3COJ
3K0H
3K0K
3K15
3K16
3PXA
3PXB
3PXC
3PXD
3PXE
4IFI
4IGK
4JLU
4OFB
4U4A
4Y18
4Y2G
6G2I
7JZV
7LYB
8GRQ
2DJA
2DMK
7QRZ
Enriched GO Terms of Interacting Partners
?
Nucleoplasm
Nucleus
DNA Damage Response
Nucleic Acid Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Metabolic Process
Cellular Response To Stress
Regulation Of Macromolecule Metabolic Process
Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
DNA Repair
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Negative Regulation Of Metabolic Process
Double-strand Break Repair
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA Metabolic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Cell Cycle Phase Transition
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cell Cycle
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Biosynthetic Process
Chromatin Binding
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Cell Cycle Phase Transition
Response To Ionizing Radiation
Response To Radiation
Positive Regulation Of Transcription By RNA Polymerase II
DNA Damage Checkpoint Signaling
Signal Transduction In Response To DNA Damage
Positive Regulation Of DNA Metabolic Process
Enzyme Binding
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Cellular Response To Stress
Chromatin Organization
Chromosome, Telomeric Region
Protein Binding
Zinc Ion Binding
Nucleus
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of RNA Metabolic Process
Ubiquitin Conjugating Enzyme Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Binding
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Microtubule
Negative Regulation Of DNA-templated Transcription
Regulation Of Primary Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Metal Ion Binding
Microtubule Binding
Post-translational Protein Modification
Protein K48-linked Ubiquitination
DNA-binding Transcription Factor Activity
Sequence-specific Double-stranded DNA Binding
Sequence-specific DNA Binding
Protein Polyubiquitination
Cytoskeleton
Negative Regulation Of RNA Metabolic Process
Ubiquitin-protein Transferase Activity
Regulation Of Macromolecule Metabolic Process
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
Protein Modification By Small Protein Conjugation
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Microtubule-based Process
Protein Ubiquitination
Regulation Of Metabolic Process
Protein K6-linked Ubiquitination
Negative Regulation Of Transcription By RNA Polymerase II
Ubiquitin Protein Ligase Activity
Identical Protein Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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