MINK1 and CASKIN1

Number of citations: 0 (PubMedID 15032605)
Data Source: HPRD (two hybrid)

		MINK1	CASKIN1
Name		misshapen like kinase 1	CASK interacting protein 1
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Postsynaptic Density Axon Dendrite Cell Projection Synapse Extracellular Exosome	Cytoplasm Postsynapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Protein Binding Identical Protein Binding
	Biological Process	MAPK Cascade Regulation Of Cell-matrix Adhesion Protein Phosphorylation JNK Cascade Chemical Synaptic Transmission Brain Development Regulation Of Cell-cell Adhesion Actin Cytoskeleton Organization Regulation Of Cell Migration Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Neuron Projection Morphogenesis Dendrite Morphogenesis Positive Regulation Of P38MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Regulation Of AMPA Receptor Activity	Signal Transduction Regulation Of Postsynaptic Density Assembly
Pathways		Oxidative Stress Induced Senescence	None
Drugs		Fostamatinib	None
GWAS		Intracranial aneurysm ( 30823506 ) Lymphocyte count ( 27863252 32888494 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Multiple sclerosis ( 31604244 ) Neutrophil percentage of white cells ( 32888494 ) PR interval ( 32439900 )	Height ( 20881960 ) Hip circumference adjusted for BMI ( 34021172 )
Interacting Genes		17 interacting genes: ABI1 ACTA2 CALM3 CASKIN1 KIFAP3 LATS1 MAP1B NCK1 NEDD4L NEFM PKP4 SPTBN2 STRIP1 TUBA1B USP7 YWHAB YWHAZ	2 interacting genes: CASK MINK1
Entrez ID		50488	57524
HPRD ID		11366	10809
Ensembl ID		ENSG00000141503	ENSG00000167971
Uniprot IDs		Q8N4C8	Q8WXD9
PDB IDs		Not available	3SEI 3SEN 7ATY
GO Terms Enriched among Interactors		Cadherin Binding Regulation Of Postsynaptic Specialization Assembly Cytoskeleton Cytoplasm Glutamatergic Synapse Regulation Of Synapse Organization Protein Sequestering Activity Negative Regulation Of Protein Localization To Nucleus Phosphoserine Residue Binding Organelle Organization Negative Regulation Of Protein Localization Protein Kinase Binding Protein Domain Specific Binding Postsynapse Regulation Of Organelle Organization Regulation Of Postsynaptic Density Assembly Structural Constituent Of Cytoskeleton Cellular Component Assembly Regulation Of Excitatory Synapse Assembly Regulation Of Cellular Component Organization Regulation Of Actin Filament Polymerization Regulation Of Intracellular Signal Transduction Regulation Of Biological Quality Transmembrane Transporter Binding Growth Cone Regulation Of Postsynapse Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Actin Filament-based Process Spindle Pole Regulation Of Supramolecular Fiber Organization Regulation Of Protein Localization To Nucleus Regulation Of Cell Communication Regulation Of Signaling Regulation Of Synapse Assembly Negative Regulation Of Transport Structural Molecule Activity Regulation Of Protein-containing Complex Assembly Positive Regulation Of Hepatic Stellate Cell Contraction Spindle Microtubule Positive Regulation Of Protein-containing Complex Assembly Induction Of Synaptic Plasticity By Chemical Substance Cell Junction Organization Cytoskeleton-dependent Intracellular Transport Protein Kinase Inhibitor Activity Lamellipodium Organization Structural Constituent Of Synapse Postsynaptic Spectrin-associated Cytoskeleton Regulation Of Hippo Signaling Positive Regulation Of Calcium-dependent Cell-cell Adhesion	Regulation Of Cell-matrix Adhesion Regulation Of Cell-substrate Adhesion Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Neurexin Family Protein Binding Nuclear Lamina GMP Kinase Activity GDP Metabolic Process Kinase Activity Protein Kinase Activity Regulation Of AMPA Receptor Activity Regulation Of Neurotransmitter Receptor Activity Regulation Of Cell Adhesion Positive Regulation Of Calcium Ion Import Negative Regulation Of Keratinocyte Proliferation Synapse Positive Regulation Of P38MAPK Cascade GMP Metabolic Process Calcium Ion Import Regulation Of Signaling Receptor Activity Phosphate-containing Compound Metabolic Process Regulation Of Keratinocyte Proliferation Negative Regulation Of Cell-matrix Adhesion Ciliary Membrane Regulation Of Calcium Ion Import Regulation Of Synaptic Vesicle Exocytosis Dendrite Morphogenesis Regulation Of P38MAPK Cascade ATP Binding JNK Cascade Negative Regulation Of Cell-substrate Adhesion Nucleotide Binding Regulation Of Neurotransmitter Secretion Regulation Of Transport Ribonucleoside Diphosphate Metabolic Process Negative Regulation Of Wound Healing Transferase Activity Nucleoside Monophosphate Metabolic Process Nucleoside Diphosphate Metabolic Process Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Basement Membrane Cell Periphery Schaffer Collateral - CA1 Synapse Positive Regulation Of Calcium Ion Transport Positive Regulation Of JNK Cascade