MINK1 and STRIP1

Number of citations: 104 (PubMedID 32707033)
Data Source: BioGRID (pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)

		MINK1	STRIP1
Name		misshapen like kinase 1	striatin interacting protein 1
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Postsynaptic Density Axon Dendrite Cell Projection Synapse Extracellular Exosome	Nucleus Cytoplasm Cytosol Extracellular Exosome FAR/SIN/STRIPAK Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Protein Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Small GTPase Binding
	Biological Process	MAPK Cascade Regulation Of Cell-matrix Adhesion Protein Phosphorylation JNK Cascade Chemical Synaptic Transmission Brain Development Regulation Of Cell-cell Adhesion Actin Cytoskeleton Organization Regulation Of Cell Migration Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Neuron Projection Morphogenesis Dendrite Morphogenesis Positive Regulation Of P38MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Regulation Of AMPA Receptor Activity	Cytoskeleton Organization Regulation Of Cell Morphogenesis Cortical Actin Cytoskeleton Organization Negative Regulation Of Hippo Signaling
Pathways		Oxidative Stress Induced Senescence	None
Drugs		Fostamatinib	None
GWAS		Intracranial aneurysm ( 30823506 ) Lymphocyte count ( 27863252 32888494 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Multiple sclerosis ( 31604244 ) Neutrophil percentage of white cells ( 32888494 ) PR interval ( 32439900 )	No GWAS studies recorded
Interacting Genes		17 interacting genes: ABI1 ACTA2 CALM3 CASKIN1 KIFAP3 LATS1 MAP1B NCK1 NEDD4L NEFM PKP4 SPTBN2 STRIP1 TUBA1B USP7 YWHAB YWHAZ	3 interacting genes: MAP4K4 MINK1 TNIK
Entrez ID		50488	85369
HPRD ID		11366	10946
Ensembl ID		ENSG00000141503	ENSG00000143093
Uniprot IDs		Q8N4C8	Q5VSL9
PDB IDs		Not available	7K36
GO Terms Enriched among Interactors		Cadherin Binding Regulation Of Postsynaptic Specialization Assembly Cytoskeleton Cytoplasm Glutamatergic Synapse Regulation Of Synapse Organization Protein Sequestering Activity Negative Regulation Of Protein Localization To Nucleus Phosphoserine Residue Binding Organelle Organization Negative Regulation Of Protein Localization Protein Kinase Binding Protein Domain Specific Binding Postsynapse Regulation Of Organelle Organization Regulation Of Postsynaptic Density Assembly Structural Constituent Of Cytoskeleton Cellular Component Assembly Regulation Of Excitatory Synapse Assembly Regulation Of Cellular Component Organization Regulation Of Actin Filament Polymerization Regulation Of Intracellular Signal Transduction Regulation Of Biological Quality Transmembrane Transporter Binding Growth Cone Regulation Of Postsynapse Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Actin Filament-based Process Spindle Pole Regulation Of Supramolecular Fiber Organization Regulation Of Protein Localization To Nucleus Regulation Of Cell Communication Regulation Of Signaling Regulation Of Synapse Assembly Negative Regulation Of Transport Structural Molecule Activity Regulation Of Protein-containing Complex Assembly Positive Regulation Of Hepatic Stellate Cell Contraction Spindle Microtubule Positive Regulation Of Protein-containing Complex Assembly Induction Of Synaptic Plasticity By Chemical Substance Cell Junction Organization Cytoskeleton-dependent Intracellular Transport Protein Kinase Inhibitor Activity Lamellipodium Organization Structural Constituent Of Synapse Postsynaptic Spectrin-associated Cytoskeleton Regulation Of Hippo Signaling Positive Regulation Of Calcium-dependent Cell-cell Adhesion	Regulation Of JNK Cascade Cell Projection Morphogenesis Neuron Projection Morphogenesis MAPK Cascade Protein Serine Kinase Activity Protein Phosphorylation Phosphorylation Protein Serine/threonine Kinase Activity Protein Kinase Activity Kinase Activity Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Intracellular Signaling Cassette Protein Autophosphorylation Regulation Of Cell-matrix Adhesion Cell Projection Organization Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of ARF Protein Signal Transduction Phosphate-containing Compound Metabolic Process Regulation Of Cell-substrate Adhesion ATP Binding Anatomical Structure Morphogenesis Positive Regulation Of Signal Transduction Protein Modification Process Positive Regulation Of Microvillus Assembly Nucleotide Binding Positive Regulation Of Cell Communication Creatine Kinase Activity Transferase Activity Intracellular Signal Transduction Positive Regulation Of Signaling MAP Kinase Kinase Kinase Kinase Activity Actin Cytoskeleton Organization Positive Regulation Of Focal Adhesion Disassembly Regulation Of Intracellular Signal Transduction Actin Filament-based Process Regulation Of Microvillus Assembly Regulation Of AMPA Receptor Activity Positive Regulation Of Keratinocyte Migration Positive Regulation Of MAPK Cascade Positive Regulation Of Cellular Component Biogenesis Regulation Of Neurotransmitter Receptor Activity Postsynaptic Density, Intracellular Component Regulation Of ARF Protein Signal Transduction Positive Regulation Of Hippo Signaling Hippo Signaling Positive Regulation Of P38MAPK Cascade Protein Metabolic Process Positive Regulation Of Focal Adhesion Assembly Regulation Of Signal Transduction