MINK1 and ACTA2

Number of citations: 0 (PubMedID 15032605)
Data Source: HPRD (two hybrid)

		MINK1	ACTA2
Name		misshapen like kinase 1	actin alpha 2, smooth muscle
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Postsynaptic Density Axon Dendrite Cell Projection Synapse Extracellular Exosome	Stress Fiber Basement Membrane Extracellular Space Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Lamellipodium Filopodium Smooth Muscle Contractile Fiber Motile Cilium Protein-containing Complex Cell Body Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity Protein Kinase Binding
	Biological Process	MAPK Cascade Regulation Of Cell-matrix Adhesion Protein Phosphorylation JNK Cascade Chemical Synaptic Transmission Brain Development Regulation Of Cell-cell Adhesion Actin Cytoskeleton Organization Regulation Of Cell Migration Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Neuron Projection Morphogenesis Dendrite Morphogenesis Positive Regulation Of P38MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Regulation Of AMPA Receptor Activity	Muscle Contraction Regulation Of Blood Pressure Response To Virus Positive Regulation Of Gene Expression Vascular Associated Smooth Muscle Contraction Positive Regulation Of Hepatic Stellate Cell Migration Positive Regulation Of Hepatic Stellate Cell Contraction Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Transforming Growth Factor Beta Stimulus Juxtaglomerular Apparatus Development Glomerular Mesangial Cell Development Mesenchyme Migration Positive Regulation Of Hepatic Stellate Cell Activation
Pathways		Oxidative Stress Induced Senescence	Smooth Muscle Contraction NOTCH4 Intracellular Domain Regulates Transcription Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Mammary Gland Myoepithelial Cells
Drugs		Fostamatinib	Phenethyl Isothiocyanate
Diseases		None	Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS		Intracranial aneurysm ( 30823506 ) Lymphocyte count ( 27863252 32888494 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Multiple sclerosis ( 31604244 ) Neutrophil percentage of white cells ( 32888494 ) PR interval ( 32439900 )	Arthritis (juvenile idiopathic) ( 33106285 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Chronic lymphocytic leukemia ( 23770605 26956414 ) Immunoglobulin A ( 20694011 ) Lymphocyte percentage of white cells ( 32888494 ) Pulse pressure ( 30578418 ) Selective IgA deficiency ( 27723758 )
Interacting Genes		17 interacting genes: ABI1 ACTA2 CALM3 CASKIN1 KIFAP3 LATS1 MAP1B NCK1 NEDD4L NEFM PKP4 SPTBN2 STRIP1 TUBA1B USP7 YWHAB YWHAZ	18 interacting genes: CCT4 CCT5 CFL1 CREBBP DNASE1 EP300 GC MINK1 MYL1 MYOC PCYT1B PRKCD SELE SHBG SNTA1 TMSB4X UBE3A YBX1
Entrez ID		50488	59
HPRD ID		11366	00031
Ensembl ID		ENSG00000141503	ENSG00000107796
Uniprot IDs		Q8N4C8	A0AAQ5BGG7 A0AAQ5BGI6 D2JYH4 P62736
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Cadherin Binding Regulation Of Postsynaptic Specialization Assembly Cytoskeleton Cytoplasm Glutamatergic Synapse Regulation Of Synapse Organization Protein Sequestering Activity Negative Regulation Of Protein Localization To Nucleus Phosphoserine Residue Binding Organelle Organization Negative Regulation Of Protein Localization Protein Kinase Binding Protein Domain Specific Binding Postsynapse Regulation Of Organelle Organization Regulation Of Postsynaptic Density Assembly Structural Constituent Of Cytoskeleton Cellular Component Assembly Regulation Of Excitatory Synapse Assembly Regulation Of Cellular Component Organization Regulation Of Actin Filament Polymerization Regulation Of Intracellular Signal Transduction Regulation Of Biological Quality Transmembrane Transporter Binding Growth Cone Regulation Of Postsynapse Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Actin Filament-based Process Spindle Pole Regulation Of Supramolecular Fiber Organization Regulation Of Protein Localization To Nucleus Regulation Of Cell Communication Regulation Of Signaling Regulation Of Synapse Assembly Negative Regulation Of Transport Structural Molecule Activity Regulation Of Protein-containing Complex Assembly Positive Regulation Of Hepatic Stellate Cell Contraction Spindle Microtubule Positive Regulation Of Protein-containing Complex Assembly Induction Of Synaptic Plasticity By Chemical Substance Cell Junction Organization Cytoskeleton-dependent Intracellular Transport Protein Kinase Inhibitor Activity Lamellipodium Organization Structural Constituent Of Synapse Postsynaptic Spectrin-associated Cytoskeleton Regulation Of Hippo Signaling Positive Regulation Of Calcium-dependent Cell-cell Adhesion	Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization Regulation Of Protein Localization To Nucleus Histone H3K27 Acetyltransferase Activity Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Protein Stabilization Regulation Of Biological Quality Extracellular Exosome Negative Regulation Of Supramolecular Fiber Organization Negative Regulation Of Cytoskeleton Organization Regulation Of Protein Localization Actin Binding Regulation Of Protein Stability Positive Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex N-terminal Protein Amino Acid Acetylation Regulation Of Telomerase RNA Localization To Cajal Body Peptidyl-lysine Acetylation Cellular Response To UV Regulation Of Cell Adhesion Regulation Of Organelle Organization Regulation Of Cellular Response To Heat Regulation Of Actin Filament Organization Regulation Of Defense Response Intracellular Signaling Cassette Acetyltransferase Activity Positive Regulation Of DNA Metabolic Process Cellular Response To Light Stimulus Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of Actin Filament Polymerization Histone Acetyltransferase Complex Regulation Of Cell-matrix Adhesion Protein-lysine-acetyltransferase Activity Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protein-containing Complex Assembly Regulation Of Actin Cytoskeleton Organization Neutrophil Activation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Focal Adhesion Assembly Binding Of Sperm To Zona Pellucida Histone Acetyltransferase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Acetylation