MINK1 and SPTBN2

Number of citations: 0 (PubMedID 15032605)
Data Source: HPRD (two hybrid)

		MINK1	SPTBN2
Name		misshapen like kinase 1	spectrin beta, non-erythrocytic 2
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Postsynaptic Density Axon Dendrite Cell Projection Synapse Extracellular Exosome	Extracellular Space Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Spectrin Membrane Apical Plasma Membrane Cell Junction Cortical Actin Cytoskeleton Paranodal Junction Cell Projection Neuronal Cell Body Parallel Fiber To Purkinje Cell Synapse Presynapse Glutamatergic Synapse Postsynaptic Spectrin-associated Cytoskeleton
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Actin Binding Structural Constituent Of Cytoskeleton Phospholipid Binding Cadherin Binding Actin Filament Binding Structural Constituent Of Synapse Structural Constituent Of Postsynapse
	Biological Process	MAPK Cascade Regulation Of Cell-matrix Adhesion Protein Phosphorylation JNK Cascade Chemical Synaptic Transmission Brain Development Regulation Of Cell-cell Adhesion Actin Cytoskeleton Organization Regulation Of Cell Migration Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Neuron Projection Morphogenesis Dendrite Morphogenesis Positive Regulation Of P38MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Regulation Of AMPA Receptor Activity	Synapse Assembly Vesicle-mediated Transport Cerebellar Purkinje Cell Layer Morphogenesis Actin Cytoskeleton Organization Adult Behavior Multicellular Organism Growth Actin Filament Capping Regulation Of Postsynaptic Specialization Assembly Postsynapse Organization
Pathways		Oxidative Stress Induced Senescence	MHC class II antigen presentation NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport
Drugs		Fostamatinib	None
Diseases		None	Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Intracranial aneurysm ( 30823506 ) Lymphocyte count ( 27863252 32888494 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Multiple sclerosis ( 31604244 ) Neutrophil percentage of white cells ( 32888494 ) PR interval ( 32439900 )	Bipolar disorder ( 21926972 28115744 31043756 ) Hip circumference adjusted for BMI ( 34021172 ) Major depressive disorder (MTAG) ( 33479212 )
Interacting Genes		17 interacting genes: ABI1 ACTA2 CALM3 CASKIN1 KIFAP3 LATS1 MAP1B NCK1 NEDD4L NEFM PKP4 SPTBN2 STRIP1 TUBA1B USP7 YWHAB YWHAZ	11 interacting genes: ACTA1 ACTB ACTR1A ADRB2 APC CELSR3 DCTN1 MINK1 PCNT SPTA1 UNC13B
Entrez ID		50488	6712
HPRD ID		11366	05404
Ensembl ID		ENSG00000141503	ENSG00000173898
Uniprot IDs		Q8N4C8	A0A087WYQ1 O15020
PDB IDs		Not available	1WJM 1WYQ 6ANU
GO Terms Enriched among Interactors		Cadherin Binding Regulation Of Postsynaptic Specialization Assembly Cytoskeleton Cytoplasm Glutamatergic Synapse Regulation Of Synapse Organization Protein Sequestering Activity Negative Regulation Of Protein Localization To Nucleus Phosphoserine Residue Binding Organelle Organization Negative Regulation Of Protein Localization Protein Kinase Binding Protein Domain Specific Binding Postsynapse Regulation Of Organelle Organization Regulation Of Postsynaptic Density Assembly Structural Constituent Of Cytoskeleton Cellular Component Assembly Regulation Of Excitatory Synapse Assembly Regulation Of Cellular Component Organization Regulation Of Actin Filament Polymerization Regulation Of Intracellular Signal Transduction Regulation Of Biological Quality Transmembrane Transporter Binding Growth Cone Regulation Of Postsynapse Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Actin Filament-based Process Spindle Pole Regulation Of Supramolecular Fiber Organization Regulation Of Protein Localization To Nucleus Regulation Of Cell Communication Regulation Of Signaling Regulation Of Synapse Assembly Negative Regulation Of Transport Structural Molecule Activity Regulation Of Protein-containing Complex Assembly Positive Regulation Of Hepatic Stellate Cell Contraction Spindle Microtubule Positive Regulation Of Protein-containing Complex Assembly Induction Of Synaptic Plasticity By Chemical Substance Cell Junction Organization Cytoskeleton-dependent Intracellular Transport Protein Kinase Inhibitor Activity Lamellipodium Organization Structural Constituent Of Synapse Postsynaptic Spectrin-associated Cytoskeleton Regulation Of Hippo Signaling Positive Regulation Of Calcium-dependent Cell-cell Adhesion	Cytoskeleton Structural Constituent Of Cytoskeleton Regulation Of Protein-containing Complex Disassembly Axon Lamellipodium Cortical Cytoskeleton Adherens Junction Cytoskeleton Organization Kinetochore Cell Cortex Microtubule Associated Complex Actin Cytoskeleton Cell Projection Morphogenesis Neuron Projection Morphogenesis Tau Protein Binding Regulation Of Organelle Organization Cell Projection Organization Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Microtubule Cytoskeleton Positive Regulation Of Mini Excitatory Postsynaptic Potential Centrosome Positive Regulation Of Synaptic Vesicle Priming Homeostatic Process Cytosol Negative Regulation Of Protein-containing Complex Disassembly Actin Filament Actin Filament-based Process Regulation Of Transport Regulation Of Mitotic Metaphase/anaphase Transition Actin Cytoskeleton Organization Regulation Of Protein Localization Regulation Of Norepinephrine Uptake Transporter Regulator Activity Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Intercellular Bridge Beta2-adrenergic Receptor Activity Positive Regulation Of Cold-induced Thermogenesis Regulation Of Microtubule Polymerization Or Depolymerization Microtubule Regulation Of Protein Depolymerization Regulation Of Supramolecular Fiber Organization Cell Cortex Region Positive Regulation Of Neuromuscular Junction Development Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Microtubule Organizing Center Dense Core Granule Priming