MINK1 and PKP4

Number of citations of the paper that reports this interaction (PMID 15032605)
1

Data Source:
HPRD (two hybrid)

		MINK1	PKP4
Gene Name		misshapen-like kinase 1	plakophilin 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Postsynaptic Density Cell Junction Axon Dendrite Postsynaptic Membrane Extracellular Vesicular Exosome	Spindle Pole Cytoplasm Cytoskeleton Plasma Membrane Cell-cell Junction Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Desmosome Midbody Cell-cell Contact Zone Perinuclear Region Of Cytoplasm Spindle Midzone Mitotic Spindle
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding	Protein Binding
	Biological Process	Regulation Of Cell-matrix Adhesion Protein Phosphorylation Response To Stress JNK Cascade Synaptic Transmission Multicellular Organismal Development Regulation Of Cell-cell Adhesion Microvillus Assembly Regulation Of Cell Migration Actin Cytoskeleton Reorganization Intracellular Signal Transduction Negative Thymic T Cell Selection Positive Regulation Of JNK Cascade Protein Autophosphorylation Dendrite Morphogenesis Regulation Of Catalytic Activity Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity	Cell-cell Junction Assembly Cell-cell Signaling Single Organismal Cell-cell Adhesion Regulation Of Cell Adhesion Positive Regulation Of Rho GTPase Activity Positive Regulation Of Cytokinesis
Pathways		Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		14 interactors: ABI1 ACTA2 CALM3 CASKIN1 KIFAP3 MAP1B NCK1 NEDD4L NEFM PKP4 SPTBN2 TUBA1B YWHAB YWHAZ	18 interactors: ATPAF2 CDH1 CDH2 CDH5 DSC3 DSP ERBB2IP GABARAP GOLGA2 LNX1 LZTS2 MINK1 OSGEP PAXIP1 PDZD2 PGAM1 PSEN1 TRIM23
Entrez ID		50488	8502
HPRD ID		11366	05043
Ensembl ID		ENSG00000141503	ENSG00000144283
Uniprot IDs		Q8N4C8	Q99569
PDB IDs
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Cytoskeleton-dependent Intracellular Transport Cellular Component Assembly Transport Movement Of Cell Or Subcellular Component Fc Receptor Signaling Pathway Regulation Of Cellular Component Size Regulation Of Cellular Component Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Establishment Of Localization In Cell Microtubule-based Transport Negative Regulation Of Transport Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Intracellular Transport Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Intracellular Transport Organelle Organization Positive Regulation Of Cation Channel Activity Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Localization Positive Regulation Of Apoptotic Signaling Pathway Axonogenesis Regulation Of Cellular Localization Cell Morphogenesis Negative Regulation Of Transporter Activity Axon Development Cell Morphogenesis Involved In Neuron Differentiation Cytoskeleton Organization Cell Development Negative Regulation Of Ion Transmembrane Transport Cell Projection Organization Lamellipodium Organization Positive Regulation Of Ion Transmembrane Transporter Activity Neuron Projection Morphogenesis Organelle Transport Along Microtubule Negative Regulation Of Transmembrane Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Transporter Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cytokinesis Positive Regulation Of Mitochondrion Organization Immune Response Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Positive Regulation Of Calcium-dependent Cell-cell Adhesion	Cell Adhesion Adherens Junction Organization Single Organismal Cell-cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Bundle Of His Cell To Purkinje Myocyte Communication Cell-cell Junction Organization Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Cellular Component Assembly Ventricular Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Cellular Response To Starvation Negative Regulation Of Canonical Wnt Signaling Pathway Cardiac Muscle Cell Action Potential Involved In Contraction Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cellular Response To Nutrient Levels Response To Starvation Cardiovascular System Development Cardiac Muscle Cell Action Potential Negative Regulation Of Wnt Signaling Pathway Autophagic Vacuole Assembly Cell Junction Assembly Regulation Of Protein Ubiquitination Intermediate Filament Cytoskeleton Organization Blood Vessel Development Intermediate Filament-based Process Cellular Response To Extracellular Stimulus Regulation Of Cardiac Muscle Cell Contraction Vasculature Development Cardiac Conduction Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Stress Macroautophagy Cajal-Retzius Cell Differentiation Positive Regulation Of Histone H3-K36 Methylation Regulation Of Pentose-phosphate Shunt Beta-amyloid Formation Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Membrane Potential Organelle Organization Cytoskeleton Organization Regulation Of Wnt Signaling Pathway Execution Phase Of Apoptosis Regulation Of Heart Rate Regulation Of Cellular Component Movement Regulation Of Cardiac Muscle Contraction Threonylcarbamoyladenosine Biosynthetic Process Basal Protein Localization
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