MINK1 and PKP4

Number of citations: 0 (PubMedID 15032605)
Data Source: HPRD (two hybrid)

		MINK1	PKP4
Name		misshapen like kinase 1	plakophilin 4
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Postsynaptic Density Axon Dendrite Cell Projection Synapse Extracellular Exosome	Spindle Pole Cornified Envelope Nucleus Cytoplasm Spindle Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Membrane Cell Junction Desmosome Midbody Organelle Cell-cell Contact Zone Perinuclear Region Of Cytoplasm Spindle Midzone Anchoring Junction Mitotic Spindle
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Protein Binding Cadherin Binding
	Biological Process	MAPK Cascade Regulation Of Cell-matrix Adhesion Protein Phosphorylation JNK Cascade Chemical Synaptic Transmission Brain Development Regulation Of Cell-cell Adhesion Actin Cytoskeleton Organization Regulation Of Cell Migration Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Neuron Projection Morphogenesis Dendrite Morphogenesis Positive Regulation Of P38MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Regulation Of AMPA Receptor Activity	Cell-cell Junction Assembly Cell Adhesion Cell-cell Signaling Regulation Of Cell Adhesion Positive Regulation Of Cytokinesis Regulation Of Rho Protein Signal Transduction Cell-cell Adhesion
Pathways		Oxidative Stress Induced Senescence	Keratinization Formation of the cornified envelope RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs		Fostamatinib	None
GWAS		Intracranial aneurysm ( 30823506 ) Lymphocyte count ( 27863252 32888494 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Multiple sclerosis ( 31604244 ) Neutrophil percentage of white cells ( 32888494 ) PR interval ( 32439900 )	Borderline personality disorder ( 28632202 ) Obesity-related traits ( 23251661 ) Restless legs syndrome ( 29029846 )
Interacting Genes		17 interacting genes: ABI1 ACTA2 CALM3 CASKIN1 KIFAP3 LATS1 MAP1B NCK1 NEDD4L NEFM PKP4 SPTBN2 STRIP1 TUBA1B USP7 YWHAB YWHAZ	20 interacting genes: ATPAF2 CDH1 CDH2 CDH5 DSC3 DSP ERBIN GABARAP GOLGA2 LNX1 LZTS2 MINK1 OGT OSGEP PAXIP1 PDZD2 PGAM1 PSEN1 TRIM23 UBASH3B
Entrez ID		50488	8502
HPRD ID		11366	05043
Ensembl ID		ENSG00000141503	ENSG00000144283
Uniprot IDs		Q8N4C8	Q99569
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Cadherin Binding Regulation Of Postsynaptic Specialization Assembly Cytoskeleton Cytoplasm Glutamatergic Synapse Regulation Of Synapse Organization Protein Sequestering Activity Negative Regulation Of Protein Localization To Nucleus Phosphoserine Residue Binding Organelle Organization Negative Regulation Of Protein Localization Protein Kinase Binding Protein Domain Specific Binding Postsynapse Regulation Of Organelle Organization Regulation Of Postsynaptic Density Assembly Structural Constituent Of Cytoskeleton Cellular Component Assembly Regulation Of Excitatory Synapse Assembly Regulation Of Cellular Component Organization Regulation Of Actin Filament Polymerization Regulation Of Intracellular Signal Transduction Regulation Of Biological Quality Transmembrane Transporter Binding Growth Cone Regulation Of Postsynapse Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Actin Filament-based Process Spindle Pole Regulation Of Supramolecular Fiber Organization Regulation Of Protein Localization To Nucleus Regulation Of Cell Communication Regulation Of Signaling Regulation Of Synapse Assembly Negative Regulation Of Transport Structural Molecule Activity Regulation Of Protein-containing Complex Assembly Positive Regulation Of Hepatic Stellate Cell Contraction Spindle Microtubule Positive Regulation Of Protein-containing Complex Assembly Induction Of Synaptic Plasticity By Chemical Substance Cell Junction Organization Cytoskeleton-dependent Intracellular Transport Protein Kinase Inhibitor Activity Lamellipodium Organization Structural Constituent Of Synapse Postsynaptic Spectrin-associated Cytoskeleton Regulation Of Hippo Signaling Positive Regulation Of Calcium-dependent Cell-cell Adhesion	Desmosome Cell Junction Cell Adhesion Gamma-catenin Binding Adherens Junction Organization Cell-cell Adhesion Cell-cell Junction Catenin Complex Beta-catenin Binding Anchoring Junction Intracellular Protein Localization Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-cell Adhesion Mediated By Cadherin Cell Junction Organization Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cytoplasm Cadherin Binding Fascia Adherens Cell-cell Junction Organization Adherens Junction Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Desmosome Organization Postsynapse Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Synapse Organization Protein Localization To Cell-cell Junction Smooth Endoplasmic Reticulum Brain Morphogenesis Regulation Of Cellular Localization Cell-cell Junction Assembly Regulation Of Protein Localization To Synapse Regulation Of Protein Localization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Receptor Localization To Synapse Plasma Membrane Protein Glycosylation Macromolecule Glycosylation Regulation Of Rac Protein Signal Transduction Cell-cell Adhesion Mediator Activity Regulation Of Protein Localization To Nucleus Cytoskeleton Organization Glycosylation Regulation Of Protein Catabolic Process Positive Regulation Of Protein Import Into Nucleus Protein Tyrosine Kinase Binding Cellular Component Assembly Regulation Of Protein Localization To Membrane Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Core Promoter Binding Protein N-acetylglucosaminyltransferase Complex