MINK1 and NEFM

Number of citations of the paper that reports this interaction (PubMedID 15032605)
0

Data Source:
HPRD (two hybrid)

		MINK1	NEFM
Description		misshapen like kinase 1	neurofilament medium chain
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Postsynaptic Density Axon Dendrite Cell Projection Synapse Extracellular Exosome	Cytoplasm Cytoskeleton Intermediate Filament Neurofilament Axon Cell Projection Intermediate Filament Cytoskeleton Neurofibrillary Tangle Postsynaptic Intermediate Filament Cytoskeleton
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Microtubule Binding
	Biological Process	MAPK Cascade Regulation Of Cell-matrix Adhesion Protein Phosphorylation JNK Cascade Chemical Synaptic Transmission Brain Development Regulation Of Cell-cell Adhesion Actin Cytoskeleton Organization Regulation Of Cell Migration Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Neuron Projection Morphogenesis Dendrite Morphogenesis Positive Regulation Of P38MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Regulation Of AMPA Receptor Activity	Neurofilament Bundle Assembly
Pathways		Oxidative Stress Induced Senescence
Drugs		Fostamatinib
Diseases
GWAS		Intracranial aneurysm ( 30823506) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Multiple sclerosis ( 31604244) Neutrophil percentage of white cells ( 32888494) PR interval ( 32439900)	Brain morphology (MOSTest) ( 32665545) Fear of minor pain ( 28701861) Idiopathic dilated cardiomyopathy ( 29495422) Interleukin-6 levels ( 22205395) Metabolite levels ( 23823483)
Interacting Genes		17 interacting genes: ABI1 ACTA2 CALM3 CASKIN1 KIFAP3 LATS1 MAP1B NCK1 NEDD4L NEFM PKP4 SPTBN2 STRIP1 TUBA1B USP7 YWHAB YWHAZ	12 interacting genes: APOE DISC1 DRD2 DSCAM FOS ITSN1 MINK1 NEFH RB1 SMAD2 STXBP1 TNIK
Entrez ID		50488	4741
HPRD ID		11366	01205
Ensembl ID		ENSG00000141503	ENSG00000104722
Uniprot IDs		Q8N4C8	P07197 Q9UK51
PDB IDs
Enriched GO Terms of Interacting Partners?		Cadherin Binding Regulation Of Postsynaptic Specialization Assembly Cytoskeleton Cytoplasm Glutamatergic Synapse Regulation Of Synapse Organization Protein Sequestering Activity Negative Regulation Of Protein Localization To Nucleus Phosphoserine Residue Binding Organelle Organization Negative Regulation Of Protein Localization Protein Kinase Binding Protein Domain Specific Binding Postsynapse Regulation Of Organelle Organization Regulation Of Postsynaptic Density Assembly Structural Constituent Of Cytoskeleton Cellular Component Assembly Regulation Of Excitatory Synapse Assembly Regulation Of Cellular Component Organization Regulation Of Actin Filament Polymerization Regulation Of Intracellular Signal Transduction Regulation Of Biological Quality Transmembrane Transporter Binding Growth Cone Regulation Of Postsynapse Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Actin Filament-based Process Spindle Pole Regulation Of Supramolecular Fiber Organization Regulation Of Protein Localization To Nucleus Regulation Of Cell Communication Regulation Of Signaling Regulation Of Synapse Assembly Negative Regulation Of Transport Structural Molecule Activity Regulation Of Protein-containing Complex Assembly Positive Regulation Of Hepatic Stellate Cell Contraction Spindle Microtubule Positive Regulation Of Protein-containing Complex Assembly Induction Of Synaptic Plasticity By Chemical Substance Cell Junction Organization Cytoskeleton-dependent Intracellular Transport Protein Kinase Inhibitor Activity Lamellipodium Organization Structural Constituent Of Synapse Postsynaptic Spectrin-associated Cytoskeleton Regulation Of Hippo Signaling Positive Regulation Of Calcium-dependent Cell-cell Adhesion	Cell Projection Organization Axon Intracellular Signal Transduction Intracellular Signaling Cassette Anatomical Structure Morphogenesis Positive Regulation Of Developmental Process Glutamatergic Synapse Cell Projection Morphogenesis Neuron Projection Morphogenesis Chemical Synaptic Transmission Trans-synaptic Signaling Synaptic Signaling Positive Regulation Of Cellular Component Organization Regulation Of Developmental Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Regulation Of Dendritic Spine Development Positive Regulation Of Cell Development Modulation Of Chemical Synaptic Transmission Developmental Process Positive Regulation Of Cell Differentiation Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Growth Hormone Secretion Regulation Of Axon Extension Cell-cell Signaling Regulation Of Growth Signal Transduction Regulation Of Growth Hormone Secretion Regulation Of Synapse Organization Positive Regulation Of Multicellular Organismal Process Signaling Regulation Of Developmental Growth Regulation Of Cellular Component Organization Cell Communication Intracellular Protein Localization Identical Protein Binding Memory Protein-containing Complex Binding Positive Regulation Of Cell Projection Organization Cell Population Proliferation Regulation Of Neurogenesis Regulation Of Postsynapse Organization Regulation Of Cell Growth Negative Regulation Of Epithelial Cell Proliferation Cell Surface Receptor Signaling Pathway SMAD Protein Signal Transduction Disordered Domain Specific Binding Regulation Of Cell Development
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