BPI and ATP6V0B

Data Source: HiPPIP (Novel)

		BPI	ATP6V0B
Name		bactericidal permeability increasing protein	ATPase H+ transporting V0 subunit b
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasmic Stress Granule Membrane Azurophil Granule Lumen Specific Granule Lumen Extracellular Exosome	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V0 Domain Lysosomal Membrane Endosome Plasma Membrane Endosome Membrane Membrane Clathrin-coated Vesicle Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase Complex Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Proton-transporting V-type ATPase, V0 Domain
	Molecular Function	Lipopolysaccharide Binding Lipid Binding	Protein Binding Proton Transmembrane Transporter Activity Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	Immune System Process Antibacterial Humoral Response Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Defense Response To Bacterium Negative Regulation Of Macrophage Activation Innate Immune Response Defense Response To Gram-negative Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide	Monoatomic Ion Transport Vacuolar Acidification Lysosomal Lumen Acidification Regulation Of Macroautophagy Endosomal Lumen Acidification Intracellular PH Reduction Golgi Lumen Acidification Proton Transmembrane Transport
Pathways		Toll Like Receptor 4 (TLR4) Cascade Neutrophil degranulation Antimicrobial peptides	ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
Drugs		Di-Stearoyl-3-Sn-Phosphatidylcholine	Tiludronic acid
GWAS		Basophil count ( 32888494 ) Carboplatin disposition in epthelial ovarian cancer ( 29367611 ) Monocyte count ( 32888494 ) Monocyte percentage of white cells ( 32888494 ) White blood cell count ( 32888494 )	Autism spectrum disorder or schizophrenia ( 28540026 )
Novel Interactors		1 novel interactors: ATP6V0B	6 novel interactors: BPI CCL19 DAPK2 RPS26P15 TTC39A ZFYVE9
Interacting Genes		1 interacting genes: PRSS2	28 interacting genes: ADGRG3 ADRB2 APOD COL4A5 EMP1 FAM210B FAS GJA8 GPR42 GPR61 INSIG2 IRAK3 KLRC1 MFF MIP MS4A3 MTNR1B NRM SLC10A1 SLC2A5 SNTA1 SPACA1 STOM TM4SF19 TMEM242 VMA21 YWHAE YWHAG
Entrez ID		671	533
HPRD ID		00174	04759
Ensembl ID		ENSG00000101425	ENSG00000117410
Uniprot IDs		A0A2R8YDF1 P17213	E9PNL3 Q99437
PDB IDs		1BP1 1EWF	6WLW 6WM2 6WM3 6WM4 7U4T 7UNF
GO Terms Enriched among Interactors		Proton-transporting V-type ATPase, V0 Domain Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Golgi Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V0 Domain Lysosomal Lumen Acidification Endosomal Lumen Acidification Proton Transmembrane Transporter Activity Proton-transporting V-type ATPase Complex Proton-transporting ATPase Activity, Rotational Mechanism Clathrin-coated Vesicle Membrane Regulation Of Lysosomal Lumen PH Vacuolar Acidification Digestion Collagen Catabolic Process Extracellular Matrix Disassembly Intracellular PH Reduction Collagen Metabolic Process	Membrane Specific Granule Membrane Gap Junction-mediated Intercellular Transport Protein Sequestering Activity Intercellular Transport