BPI

Name	bactericidal permeability increasing protein
Structure
Novel Interactors	1 novel interactors: ATP6V0B
Interactors	1 interactors: PRSS2
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasmic Stress Granule Membrane Azurophil Granule Lumen Specific Granule Lumen Extracellular Exosome
	Molecular Function	Lipopolysaccharide Binding Lipid Binding
	Biological Process	Immune System Process Antibacterial Humoral Response Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Defense Response To Bacterium Negative Regulation Of Macrophage Activation Innate Immune Response Defense Response To Gram-negative Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide
Pathways	Toll Like Receptor 4 (TLR4) Cascade Neutrophil degranulation Antimicrobial peptides
Drugs	Di-Stearoyl-3-Sn-Phosphatidylcholine
GWAS	Basophil count ( 32888494 ) Carboplatin disposition in epthelial ovarian cancer ( 29367611 ) Monocyte count ( 32888494 ) Monocyte percentage of white cells ( 32888494 ) White blood cell count ( 32888494 )
Entrez ID	671
HPRD ID	00174
Ensembl ID	ENSG00000101425
Uniprot IDs	A0A2R8YDF1 P17213
PDB IDs	1BP1 1EWF
GO Terms Enriched among Interactors ?	Proton-transporting V-type ATPase, V0 Domain Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Golgi Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V0 Domain Lysosomal Lumen Acidification Endosomal Lumen Acidification Proton Transmembrane Transporter Activity Proton-transporting V-type ATPase Complex Proton-transporting ATPase Activity, Rotational Mechanism Clathrin-coated Vesicle Membrane Regulation Of Lysosomal Lumen PH Vacuolar Acidification Digestion Collagen Catabolic Process Extracellular Matrix Disassembly Intracellular PH Reduction Collagen Metabolic Process