BPI and PRSS2

Number of citations of the paper that reports this interaction (PMID 11420435)
2

Data Source:
HPRD (in vitro)

		BPI	PRSS2
Gene Name		bactericidal/permeability-increasing protein	protease, serine, 2 (trypsin 2)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Integral Component Of Plasma Membrane Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Lipopolysaccharide Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Immune Response Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Macrophage Activation Defense Response To Gram-negative Bacterium	Proteolysis Digestion Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Growth Collagen Catabolic Process Innate Immune Response Positive Regulation Of Cell Adhesion
Pathways			Collagen degradation Activation of Matrix Metalloproteinases Alpha-defensins Defensins Degradation of the extracellular matrix Innate Immune System
Drugs		Di-Stearoyl-3-Sn-Phosphatidylcholine
Diseases
GWAS			Pancreatitis ( 23143602)
Protein-Protein Interactions		1 interactors: PRSS2	6 interactors: APP BPI CSN1S1 MMP9 SERPINA1 SLPI
Entrez ID		671	5645
HPRD ID		00174	03335
Ensembl ID		ENSG00000101425
Uniprot IDs		P17213	A6XMV8 A6XMV9 P07478 Q5NV56
PDB IDs		1BP1 1EWF
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Digestion Positive Regulation Of Cell Growth Positive Regulation Of Growth Regulation Of Cell Growth Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cell Adhesion	Regulation Of Protein Binding Negative Regulation Of Endopeptidase Activity Regulation Of Binding Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Platelet Degranulation Response To Methanol Regulation Of Proteolysis Response To External Stimulus Response To Triglyceride Synaptic Growth At Neuromuscular Junction Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Collateral Sprouting In Absence Of Injury Negative Regulation Of Protein Metabolic Process Response To Chromate Positive Regulation Of Receptor Binding Platelet Activation Positive Regulation Of Keratinocyte Migration Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Serine-type Peptidase Activity Axon Choice Point Recognition Negative Regulation Of Macrophage Activation Neuron Remodeling Exocytosis Defense Response Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Interleukin-8 Production Axon Guidance Blood Coagulation Cellular Copper Ion Homeostasis Hemostasis Negative Regulation Of Cation Channel Activity Macrophage Differentiation Copper Ion Homeostasis Suckling Behavior Response To Bacterium Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Secretion By Cell Regulation Of Macrophage Activation Response To Lead Ion
Tagcloud ?		acetate azurophilic bactericidal c5a elastase ex fmlp granule inducers lasted leukocytes lipopolysaccharide lipoteichoic lta magnitude mediator microbial myristate permeability phorbol pmnl polymorphonuclear potently release released started stored stz zymosan	alternating appreciated blocks border boundary colocalizes dimethylation extending extends fails h3ac h3k4me2 h3k9me2 helps initiate insulator integrity interspersed ltr opening repressive retroviral segments speculate spread tcrb thymocytes transgene trypsinogen
Tagcloud (Difference) ?		acetate azurophilic bactericidal c5a elastase ex fmlp granule inducers lasted leukocytes lipopolysaccharide lipoteichoic lta magnitude mediator microbial myristate permeability phorbol pmnl polymorphonuclear potently release released started stored stz zymosan	alternating appreciated blocks border boundary colocalizes dimethylation extending extends fails h3ac h3k4me2 h3k9me2 helps initiate insulator integrity interspersed ltr opening repressive retroviral segments speculate spread tcrb thymocytes transgene trypsinogen
Tagcloud (Intersection) ?