BPI and PRSS2

Number of citations: 36 (PubMedID 11420435)
Data Source: HPRD (in vitro)

		BPI	PRSS2
Name		bactericidal permeability increasing protein	serine protease 2
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasmic Stress Granule Membrane Azurophil Granule Lumen Specific Granule Lumen Extracellular Exosome	Extracellular Region Extracellular Space Extracellular Matrix Azurophil Granule Lumen
	Molecular Function	Lipopolysaccharide Binding Lipid Binding	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Immune System Process Antibacterial Humoral Response Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Defense Response To Bacterium Negative Regulation Of Macrophage Activation Innate Immune Response Defense Response To Gram-negative Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide	Proteolysis Digestion Antimicrobial Humoral Response Extracellular Matrix Disassembly Positive Regulation Of Cell Growth Collagen Catabolic Process Positive Regulation Of Cell Adhesion
Pathways		Toll Like Receptor 4 (TLR4) Cascade Neutrophil degranulation Antimicrobial peptides	Collagen degradation Alpha-defensins Activation of Matrix Metalloproteinases Neutrophil degranulation Antimicrobial peptides
Drugs		Di-Stearoyl-3-Sn-Phosphatidylcholine	Monoisopropylphosphorylserine O-Benzylsulfonyl-Serine Benzylamine Benzamidine Phosphorylisopropane Phenethylamine 3-Phenylpropylamine
Diseases		None	Hereditary pancreatitis; Hereditary chronic pancreatitis
GWAS		Basophil count ( 32888494 ) Carboplatin disposition in epthelial ovarian cancer ( 29367611 ) Monocyte count ( 32888494 ) Monocyte percentage of white cells ( 32888494 ) White blood cell count ( 32888494 )	Pancreatitis ( 23143602 )
Novel Interactors		1 novel interactors: ATP6V0B	2 novel interactors: DMBT1 MKKS
Interacting Genes		1 interacting genes: PRSS2	7 interacting genes: APP BPI CSN1S1 GLP1R MMP9 SERPINA1 SLPI
Entrez ID		671	5645
HPRD ID		00174	03335
Ensembl ID		ENSG00000101425	ENSG00000275896
Uniprot IDs		A0A2R8YDF1 P17213	A0A0J9YYC8 A6XMV9 P07478 Q5NV56 Q6PK75
PDB IDs		1BP1 1EWF	Not available
GO Terms Enriched among Interactors		Proton-transporting V-type ATPase, V0 Domain Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Golgi Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V0 Domain Lysosomal Lumen Acidification Endosomal Lumen Acidification Proton Transmembrane Transporter Activity Proton-transporting V-type ATPase Complex Proton-transporting ATPase Activity, Rotational Mechanism Clathrin-coated Vesicle Membrane Regulation Of Lysosomal Lumen PH Vacuolar Acidification Digestion Collagen Catabolic Process Extracellular Matrix Disassembly Intracellular PH Reduction Collagen Metabolic Process	Antibacterial Humoral Response Extracellular Space Antimicrobial Humoral Response Humoral Immune Response Heparan Sulfate Binding Defense Response To Bacterium Serine-type Endopeptidase Inhibitor Activity Extracellular Region Defense Response To Gram-negative Bacterium Peptidase Inhibitor Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Response To Bacterium Extracellular Matrix Lipopolysaccharide Binding Extracellular Exosome Innate Immune Response Response To External Biotic Stimulus Negative Regulation Of Blood Pressure Defense Response Amyloid-beta Complex Growth Cone Lamellipodium Defense Response To Symbiont Regulation Of Response To Calcium Ion Platelet Alpha Granule Lumen Defense Response To Other Organism Regulation Of Multicellular Organism Growth Amylin Binding Response To Amyloid-beta Positive Regulation Of Toll Signaling Pathway Specific Granule Lumen Response To Lipopolysaccharide Response To Lipid Response To 11-deoxycorticosterone Zymogen Binding Glucagon-like Peptide 1 Receptor Activity Response To Molecule Of Bacterial Origin Cellular Response To Oxygen-containing Compound Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Pigment Granule Aggregation In Cell Center PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization