SP4 and POU2F1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SP4	POU2F1
Gene Name		Sp4 transcription factor	POU class 2 homeobox 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Microtubule Cytoskeleton Intercellular Bridge	Nucleus Nucleoplasm Transcription Factor Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Transcription Coactivator Activity Metal Ion Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Heart Contraction	Transcription From RNA Polymerase III Promoter Gene Expression Olfactory Placode Formation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Lens Induction In Camera-type Eye
Pathways			RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase III Abortive And Retractive Initiation
Drugs
Diseases
GWAS		Major depressive disorder ( 20125088) Major depressive disorder (broad) ( 20038947) Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma) ( 23103227)	Liver enzyme levels ( 18940312)
Protein-Protein Interactions		14 interactors: ADAM15 ATXN7L1 CIB3 COL8A1 E2F1 FOXP2 LMO3 NKX3-1 NRF1 POU2F1 PRR20A SERF2 SP1 ZBTB7A	50 interactors: AES APP AR BARD1 BRCA1 CEBPE CREB1 EPRS ESR1 FDXR HCFC1 HMGA1 HMGB2 HNF1A HOXB13 HOXC9 IRF9 LIFR MNAT1 MSX1 NCOR2 NFYA NPAT NR3C1 PARP1 PBX1 PGR PKNOX1 PLK3 POGZ POU2AF1 PRKACA PRKDC RARA RELA RXRA SNAPC4 SOX2 SP1 SP4 STAT5A STAT5B TBP THRA TLE4 TLX2 TNF TXNRD1 VDR XRCC6
Entrez ID		6671	5451
HPRD ID		02764	01250
Ensembl ID		ENSG00000105866	ENSG00000143190
Uniprot IDs		Q02446	J3KP77 P14859
PDB IDs			1CQT 1E3O 1GT0 1HF0 1O4X 1OCT 1POG 1POU
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Receptor Binding Organ Development RNA Metabolic Process Camera-type Eye Development Multicellular Organismal Development Gene Expression Eye Development Transcription From RNA Polymerase II Promoter Camera-type Eye Morphogenesis Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Tissue Development Organ Morphogenesis Eye Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Formation Involved In Morphogenesis Developmental Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription System Development Negative Regulation Of RNA Biosynthetic Process Sensory Organ Development Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Respiratory System Development Response To Hypoxia Regulation Of Gene Expression Anatomical Structure Development Negative Regulation Of Protein Binding Regulation Of Nitrogen Compound Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Collagen Catabolic Process Positive Regulation Of Cellular Biosynthetic Process Cardiovascular System Development	Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Gland Development Negative Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Organ Development Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Response To Hormone DNA-templated Transcription, Initiation Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Response To Steroid Hormone Organ Morphogenesis Reproductive Process Hormone-mediated Signaling Pathway Anatomical Structure Morphogenesis Intracellular Receptor Signaling Pathway Multicellular Organismal Development System Development
Tagcloud ?			build built compendium connected controlling databases delineate deoxyribonuclease encode experimentally footprinting gata3 hnf1b hypersensitivity klf4 locations matrices motifs orthologs rarb runx2 rxra silico smad3 sp1 sp3 umod upstream uromodulin
Tagcloud (Difference) ?			build built compendium connected controlling databases delineate deoxyribonuclease encode experimentally footprinting gata3 hnf1b hypersensitivity klf4 locations matrices motifs orthologs rarb runx2 rxra silico smad3 sp1 sp3 umod upstream uromodulin
Tagcloud (Intersection) ?