SP4 and LMO3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SP4	LMO3
Description		Sp4 transcription factor	LIM domain only 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding	Transcription Coactivator Activity Protein Binding Metal Ion Binding DNA-binding Transcription Factor Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 29348612) Age at first sexual intercourse ( 34211149) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Bipolar disorder ( 31043756 34002096) General cognitive ability ( 29844566) LDL cholesterol levels ( 32203549) Major depressive disorder ( 20125088) Major depressive disorder (broad) ( 20038947) Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma) ( 23103227) Multisite chronic pain ( 31194737 33830993) Plateletcrit ( 32888494) Schizophrenia ( 30285260) Temporomandibular joint disorder ( 28081371)	Barrett's esophagus or Esophageal adenocarcinoma ( 32918910) Barrett's esophagus or esophageal adenocarcinoma x sex interaction (2df test) ( 32918910) Chronotype ( 30696823) Household income (MTAG) ( 31844048) Metastatic colorectal cancer survival in treatment with chemotherapy plus biologics ( 32958699) Smoking initiation ( 33082346) Tourette syndrome ( 30818990) Worry too long after an embarrassing experience ( 29500382)
Interacting Genes		35 interacting genes: ADAM15 AP1M1 ATXN7L1 BANP CIB3 COL8A1 E2F1 ELK3 FOXP2 GTF2A1 HIVEP1 HYPK LMO3 LNX1 MCRS1 NFYC NKX3-1 NRF1 PELI2 PNKP POGZ POU2F1 PRR20A PRR20B PRR20C PRR20D PRR20E PRSS59P SERF2 SP1 SPANXN2 SPANXN3 USP7 VEZF1 ZBTB7A	124 interacting genes: ABI2 ACTMAP AIMP2 AMIGO1 AMOTL2 AVPI1 BANP BCAS2 BEND5 BEND7 BHLHE40 BLZF1 CARD9 CARF CBY2 CCDC33 CCDC85B CCSER1 CDYL2 CEP170P1 CEP57 CEP57L1 CYSRT1 DCDC2 DVL2 DYRK1A FAM131C FBLIM1 FOS GABPB1 GMEB2 GOLGA2 GOLGA6L9 GPATCH2L HMBOX1 HNRNPC HNRNPH1 HNRNPM HOMEZ HSPB2 HSPB2-C11orf52 IKZF1 IL16 INCA1 ITSN1 KANK2 KCTD1 KIF2A KRABD4 KRT31 KRT38 KXD1 LDB1 LDB2 LIMS1 LNPK LPXN LZTS1 LZTS2 MAD1L1 MALSU1 MBD3 MBD3L1 MBIP MDFI MEIS3 MID2 MTUS2 MYOG MYOZ3 NBPF22P NDOR1 NFKBID NHLH2 NIF3L1 NTAQ1 NUTM1 PELO PHC2 PICK1 PNMA1 POU6F2 PPP1R13B PXN QRICH1 RALYL RCN1 RFC5 RFX6 RORA SAMD3 SH2B2 SHISA6 SLAIN1 SP4 TAX1BP1 TCP10L TEPSIN THAP1 TMEM121 TRAPPC2L TRIB3 TRIM23 TRIM54 TUFT1 USP54 VBP1 VMAC VPS28 WASHC1 WWOX ZBTB43 ZBTB8A ZBTB8B ZIM3 ZNF143 ZNF526 ZNF587 ZNF620 ZNF641 ZNF69 ZNF84 ZRANB1 ZSCAN9
Entrez ID		6671	55885
HPRD ID		02764	11832
Ensembl ID		ENSG00000105866	ENSG00000048540
Uniprot IDs		A0A3B3IRW4 Q02446 Q32M51	Q8TAP4 Q9NYC6
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding DNA Binding Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Binding Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA Damage Response Sequence-specific Double-stranded DNA Binding	Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Identical Protein Binding Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process DNA Binding Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Microtubule Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
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