SP4

Gene Name		Sp4 transcription factor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Microtubule Cytoskeleton Intercellular Bridge
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Transcription Coactivator Activity Metal Ion Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Heart Contraction
Pathways
Drugs
Diseases
GWAS		Major depressive disorder ( 20125088) Major depressive disorder (broad) ( 20038947) Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma) ( 23103227)
Protein-protein Interactions		14 interactors: ADAM15 ATXN7L1 CIB3 COL8A1 E2F1 FOXP2 LMO3 NKX3-1 NRF1 POU2F1 PRR20A SERF2 SP1 ZBTB7A
Entrez ID		6671
HPRD ID		02764
Ensembl ID		ENSG00000105866
Uniprot IDs		Q02446
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Receptor Binding Organ Development RNA Metabolic Process Camera-type Eye Development Multicellular Organismal Development Gene Expression Eye Development Transcription From RNA Polymerase II Promoter Camera-type Eye Morphogenesis Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Tissue Development Organ Morphogenesis Eye Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Formation Involved In Morphogenesis Developmental Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription System Development Negative Regulation Of RNA Biosynthetic Process Sensory Organ Development Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Respiratory System Development Response To Hypoxia Regulation Of Gene Expression Anatomical Structure Development Negative Regulation Of Protein Binding Regulation Of Nitrogen Compound Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Collagen Catabolic Process Positive Regulation Of Cellular Biosynthetic Process Cardiovascular System Development
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