SP4 and SPANXN2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SP4	SPANXN2
Description		Sp4 transcription factor	SPANX family member N2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding	Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 29348612) Age at first sexual intercourse ( 34211149) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Bipolar disorder ( 31043756 34002096) General cognitive ability ( 29844566) LDL cholesterol levels ( 32203549) Major depressive disorder ( 20125088) Major depressive disorder (broad) ( 20038947) Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma) ( 23103227) Multisite chronic pain ( 31194737 33830993) Plateletcrit ( 32888494) Schizophrenia ( 30285260) Temporomandibular joint disorder ( 28081371)
Interacting Genes		35 interacting genes: ADAM15 AP1M1 ATXN7L1 BANP CIB3 COL8A1 E2F1 ELK3 FOXP2 GTF2A1 HIVEP1 HYPK LMO3 LNX1 MCRS1 NFYC NKX3-1 NRF1 PELI2 PNKP POGZ POU2F1 PRR20A PRR20B PRR20C PRR20D PRR20E PRSS59P SERF2 SP1 SPANXN2 SPANXN3 USP7 VEZF1 ZBTB7A	50 interacting genes: ANKRD1 ANKRD11 BANP BEND7 BIVM CDC14B CDCA8 CDYL2 COIL DPPA4 EPB41L3 FAM193B FAM204A GPRASP3 H2BC11 H2BC15 H2BC21 KHDC4 KRCC1 L3MBTL3 MEOX2 MTIF3 NOL12 NUMB PBX4 PICK1 RPL27 RRP1 SFMBT1 SMN1 SMN2 SNIP1 SNRPD2 SP3 SP4 SRP14 STAC3 SYTL4 THAP1 TNNI1 VAX1 YAF2 ZBTB48 ZNF19 ZNF2 ZNF438 ZNF526 ZNF655 ZNF75A ZNF84
Entrez ID		6671	494119
HPRD ID		02764	18091
Ensembl ID		ENSG00000105866	ENSG00000268988
Uniprot IDs		A0A3B3IRW4 Q02446 Q32M51	Q5MJ10
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding DNA Binding Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Binding Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA Damage Response Sequence-specific Double-stranded DNA Binding	Nucleus DNA Binding Spliceosomal SnRNP Assembly Spliceosomal Complex Assembly SMN-Sm Protein Complex Nucleoplasm Protein-RNA Complex Assembly Zinc Ion Binding Sequence-specific DNA Binding SMN Complex Gemini Of Cajal Bodies Protein Binding
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