SRF and ATF6

Number of citations of the paper that reports this interaction (PubMedID 9271374)
30

Data Source:
HPRD (in vitro)

		SRF	ATF6
Description		serum response factor	activating transcription factor 6
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	Golgi Membrane Chromatin Nucleus Nuclear Envelope Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Serum Response Element Binding Chromatin DNA Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Primary MiRNA Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Identical Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Branching Involved In Blood Vessel Morphogenesis Response To Hypoxia In Utero Embryonic Development Mesoderm Formation Neuron Migration Trophectodermal Cell Differentiation Heart Looping Morphogenesis Of An Epithelial Sheet Cell Migration Involved In Sprouting Angiogenesis Leukocyte Differentiation Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Actin Filament Organization Cell-matrix Adhesion Gastrulation Heart Development Long-term Memory Negative Regulation Of Cell Population Proliferation Associative Learning Response To Toxic Substance Response To Hormone Epithelial Structure Maintenance Hippocampus Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Actin Cytoskeleton Organization Contractile Actin Filament Bundle Assembly Regulation Of Cell Adhesion Platelet Activation Platelet Formation Negative Regulation Of Cell Migration Thyroid Gland Development Forebrain Development Neuron Projection Development Response To Cytokine Megakaryocyte Development Dorsal Aorta Morphogenesis Wound Healing Stress Fiber Assembly Skin Morphogenesis Positive Thymic T Cell Selection Sarcomere Organization Positive Regulation Of Cell Differentiation Positive Regulation Of Axon Extension Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Transcription By Glucose Muscle Cell Cellular Homeostasis Filopodium Assembly Thymus Development Developmental Growth Neuron Development Axon Extension Erythrocyte Development Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Filopodium Assembly Cardiac Myofibril Assembly Angiogenesis Involved In Wound Healing Hematopoietic Stem Cell Differentiation Positive Regulation Of Transcription Initiation By RNA Polymerase II Long-term Synaptic Depression Face Development Heart Trabecula Formation Cardiac Muscle Cell Myoblast Differentiation Lung Morphogenesis Bronchus Cartilage Development Trachea Cartilage Development Cardiac Vascular Smooth Muscle Cell Differentiation Eyelid Development In Camera-type Eye Lung Smooth Muscle Development Establishment Of Skin Barrier Bicellular Tight Junction Assembly Cellular Response To Glucose Stimulus Primitive Streak Formation Epithelial Cell-cell Adhesion Cellular Senescence Cell-cell Adhesion Negative Regulation Of Amyloid-beta Clearance Negative Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Transcription	Eye Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Folding Response To Unfolded Protein Signal Transduction Visual Perception Positive Regulation Of Autophagy Endoplasmic Reticulum Unfolded Protein Response Response To Endoplasmic Reticulum Stress ATF6-mediated Unfolded Protein Response ERAD Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of ATF6-mediated Unfolded Protein Response
Pathways		RHO GTPases Activate Formins NGF-stimulated transcription NGF-stimulated transcription Estrogen-dependent nuclear events downstream of ESR-membrane signaling Cardiogenesis Regulation of NPAS4 gene transcription	ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperones ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes Modulation of host responses by IFN-stimulated genes
Drugs			Pseudoephedrine
Diseases
GWAS			Chronic bronchitis in chronic obstructive pulmonary disease ( 25241909) Parkinson's disease (age of onset) ( 19772629) Severe insulin-deficient type 2 diabetes ( 34737425) Systemic sclerosis ( 30247649)
Interacting Genes		71 interacting genes: ALDH3A1 ATF6 BARX2 CAMK2A CASP3 CASP6 CASP7 CASP8 CASP9 CD63 CEBPB CIRBP CREB1 CREBBP CRIP2 CSNK2A1 ELK1 ELK4 ETV4 FHL1 FHL2 FHL3 FHL5 FLI1 FOXG1 FOXK1 GATA4 GTF2F1 GTF2I HDAC4 HMGA1 HOPX KAT5 KDM6A MAPKAPK2 MINPP1 MRTFA MRTFB MYOCD MYOD1 MYOG NCOA1 NCOA6 NCOR2 NFKB1 NFYA NKX2-3 NKX2-5 NKX3-1 OGT PML PRKDC PRRX1 PYCARD RARA REL RELA RPS6KA1 RXRA RXRG SHBG SP1 SRC SRFBP1 SSRP1 TCF3 TEAD1 TRIM63 TRIP4 UBE2I ZIC3	18 interacting genes: APP ATF6B BPGM CREB1 CREB3L3 DAPK1 DDC GTF2I MAGI1 NFYA NFYC NNMT RNF168 SRF TNFRSF1A UBASH3A XBP1 YY1
Entrez ID		6722	22926
HPRD ID		02788	16118
Ensembl ID		ENSG00000112658	ENSG00000118217
Uniprot IDs		B4DU24 P11831	A0A7P0TAF2 A0A7P0Z421 A8K383 P18850
PDB IDs		1HBX 1K6O 1SRS
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Nucleus Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Regulator Complex Transcription Cis-regulatory Region Binding DNA Binding Animal Organ Development Sequence-specific Double-stranded DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Differentiation Negative Regulation Of RNA Metabolic Process Cellular Developmental Process Developmental Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Transcription Regulator Complex Response To Lipid Muscle Cell Differentiation DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Response To Cytokine Chromatin Binding Negative Regulation Of Macromolecule Metabolic Process	Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Transcription Cis-regulatory Region Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Metabolic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of RNA Metabolic Process Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of MiRNA Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process CCAAT-binding Factor Complex DNA Binding Regulation Of Gene Expression Protein-DNA Complex Response To Cytokine Regulation Of Macromolecule Biosynthetic Process Response To Peptide Nucleobase-containing Compound Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process ATF6-mediated Unfolded Protein Response Hemopoiesis Regulation Of Metabolic Process Myeloid Cell Development Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Regulation Of MiRNA Transcription Response To Stress Nucleobase-containing Compound Metabolic Process Cis-regulatory Region Sequence-specific DNA Binding Cellular Response To Stress Nucleoplasm Response To Unfolded Protein Regulation Of MiRNA Metabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Associative Learning Regulation Of Cellular Response To Stress
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