SRF and ZIC3

Number of citations: 0 (PubMedID 17468179)
Data Source: BioGRID (pull down)

		SRF	ZIC3
Name		serum response factor	Zic family zinc finger 3
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Serum Response Element Binding Chromatin DNA Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Primary MiRNA Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Branching Involved In Blood Vessel Morphogenesis Response To Hypoxia In Utero Embryonic Development Mesoderm Formation Neuron Migration Trophectodermal Cell Differentiation Heart Looping Morphogenesis Of An Epithelial Sheet Cell Migration Involved In Sprouting Angiogenesis Leukocyte Differentiation Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Actin Filament Organization Cell-matrix Adhesion Gastrulation Heart Development Long-term Memory Negative Regulation Of Cell Population Proliferation Associative Learning Response To Toxic Substance Response To Hormone Epithelial Structure Maintenance Hippocampus Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Actin Cytoskeleton Organization Contractile Actin Filament Bundle Assembly Regulation Of Cell Adhesion Platelet Activation Platelet Formation Negative Regulation Of Cell Migration Thyroid Gland Development Forebrain Development Neuron Projection Development Response To Cytokine Megakaryocyte Development Dorsal Aorta Morphogenesis Wound Healing Stress Fiber Assembly Skin Morphogenesis Positive Thymic T Cell Selection Sarcomere Organization Positive Regulation Of Cell Differentiation Positive Regulation Of Axon Extension Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Transcription By Glucose Muscle Cell Cellular Homeostasis Filopodium Assembly Thymus Development Developmental Growth Neuron Development Axon Extension Erythrocyte Development Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Filopodium Assembly Cardiac Myofibril Assembly Angiogenesis Involved In Wound Healing Hematopoietic Stem Cell Differentiation Positive Regulation Of Transcription Initiation By RNA Polymerase II Long-term Synaptic Depression Face Development Heart Trabecula Formation Cardiac Muscle Cell Myoblast Differentiation Lung Morphogenesis Bronchus Cartilage Development Trachea Cartilage Development Cardiac Vascular Smooth Muscle Cell Differentiation Eyelid Development In Camera-type Eye Lung Smooth Muscle Development Establishment Of Skin Barrier Bicellular Tight Junction Assembly Cellular Response To Glucose Stimulus Primitive Streak Formation Epithelial Cell-cell Adhesion Cellular Senescence Cell-cell Adhesion Negative Regulation Of Amyloid-beta Clearance Negative Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Transcription	Skeletal System Development Neural Plate Development Heart Looping Atrial Cardiac Muscle Tissue Development Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Determination Of Left/right Symmetry Gastrulation Pattern Specification Process Nervous System Development Central Nervous System Development Mesoderm Development Heart Development Embryonic Pattern Specification Anterior/posterior Pattern Specification Gene Expression Stem Cell Population Maintenance Hippocampus Development Olfactory Bulb Development Cell Differentiation Neuron Differentiation Lung Development Germ-line Stem Cell Population Maintenance Forebrain Development Limb Morphogenesis Central Nervous System Segmentation Determination Of Pancreatic Left/right Asymmetry Determination Of Left/right Asymmetry In Nervous System Outer Ear Morphogenesis MRNA Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Axial Mesoderm Development Paraxial Mesoderm Development Stem Cell Differentiation Face Development Left/right Pattern Formation Left/right Axis Specification Determination Of Digestive Tract Left/right Asymmetry Determination Of Liver Left/right Asymmetry Primitive Streak Formation Maintenance Of Cell Number Cranial Skeletal System Development
Pathways		RHO GTPases Activate Formins NGF-stimulated transcription NGF-stimulated transcription Estrogen-dependent nuclear events downstream of ESR-membrane signaling Cardiogenesis Regulation of NPAS4 gene transcription	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells
Diseases		None	Heterotaxy; Situs ambiguus
GWAS		No GWAS studies recorded	Refractive error ( 32231278 )
Novel Interactors		None recorded	2 novel interactors: DNAI1 POFUT1
Interacting Genes		71 interacting genes: ALDH3A1 ATF6 BARX2 CAMK2A CASP3 CASP6 CASP7 CASP8 CASP9 CD63 CEBPB CIRBP CREB1 CREBBP CRIP2 CSNK2A1 ELK1 ELK4 ETV4 FHL1 FHL2 FHL3 FHL5 FLI1 FOXG1 FOXK1 GATA4 GTF2F1 GTF2I HDAC4 HMGA1 HOPX KAT5 KDM6A MAPKAPK2 MINPP1 MRTFA MRTFB MYOCD MYOD1 MYOG NCOA1 NCOA6 NCOR2 NFKB1 NFYA NKX2-3 NKX2-5 NKX3-1 OGT PML PRKDC PRRX1 PYCARD RARA REL RELA RPS6KA1 RXRA RXRG SHBG SP1 SRC SRFBP1 SSRP1 TCF3 TEAD1 TRIM63 TRIP4 UBE2I ZIC3	7 interacting genes: CTNNB1 GLI3 MESP1 SRF TP53 TWIST1 UBASH3A
Entrez ID		6722	7547
HPRD ID		02788	02225
Ensembl ID		ENSG00000112658	ENSG00000156925
Uniprot IDs		B4DU24 P11831	O60481
PDB IDs		1HBX 1K6O 1SRS	2EJ4 2RPC
GO Terms Enriched among Interactors		Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Nucleus Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Regulator Complex Transcription Cis-regulatory Region Binding DNA Binding Animal Organ Development Sequence-specific Double-stranded DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Differentiation Negative Regulation Of RNA Metabolic Process Cellular Developmental Process Developmental Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Transcription Regulator Complex Response To Lipid Muscle Cell Differentiation DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Response To Cytokine Chromatin Binding Negative Regulation Of Macromolecule Metabolic Process	Heart Development Gastrulation Pattern Specification Process Embryonic Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Regionalization In Utero Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Chordate Embryonic Development Cis-regulatory Region Sequence-specific DNA Binding Stem Cell Differentiation Smooth Muscle Cell Differentiation Histone Deacetylase Binding Developmental Growth Animal Organ Development Tissue Morphogenesis Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Neuroblast Proliferation T Cell Differentiation In Thymus Cardiac Vascular Smooth Muscle Cell Differentiation Neuroblast Proliferation Embryonic Digit Morphogenesis Animal Organ Morphogenesis Formation Of Primary Germ Layer Cell Motility Forebrain Development Positive Regulation Of DNA-templated Transcription Initiation Cranial Suture Morphogenesis Regulation Of MiRNA Transcription Stem Cell Proliferation Embryonic Skeletal System Morphogenesis Embryonic Limb Morphogenesis Regulation Of Stem Cell Proliferation Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Initiation Vascular Associated Smooth Muscle Cell Differentiation Tube Morphogenesis Negative Regulation Of Cell Differentiation Regulation Of MiRNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Neural Precursor Cell Proliferation Thymocyte Apoptotic Process Neural Precursor Cell Proliferation Tissue Development Hematopoietic Or Lymphoid Organ Development Morphogenesis Of An Epithelium